Protein Alignment CASK and Cask

DIOPT Version :10

• Sequence 1: NP_001354650.1
• Gene: CASK / 8573
• HGNCID: 1497
• Length: 926
• Species: Homo sapiens
• Sequence 2: XP_011245733.1
• Gene: Cask / 12361
• MGIID: 1309489
• Length: 972
• Species: Mus musculus
• Alignment Length: 972
• Identity: 924/972 - (95%)
• Similarity: 926/972 - (95%)
• Gaps: 46/972 - (4%)

Human     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTE------DL 59
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||      :|
Mouse     1 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEGKRWISNL 65

Human    60 KREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQ 124
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 KREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQ 130

Human   125 ILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 189
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 ILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 195

Human   190 VVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVR 254
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 VVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVR 260

Human   255 RMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNS 319
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 RMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNS 325

Human   320 FYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLL 384
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 FYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLL 390

Human   385 DLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAH 449
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 DLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAH 455

Human   450 EVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCI 514
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 EVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCI 520

Human   515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCE 579
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCE 585

Human   580 RDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGD 644
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 RDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGD 650

Human   645 IIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYK 709
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 IIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYK 715

Human   710 DKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHT 774
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 DKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHT 780

Human   775 TRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEP 839
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 TRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEP 845

Human   840 Q----------------------------------------ALKVLRTAEFAPFVVFIAAPTITP 864
            |                                        ||||||||||||||||||||||||
Mouse   846 QGLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLLALKVLRTAEFAPFVVFIAAPTITP 910

Human   865 GLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 926
            ||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   911 GLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CASK	NP_001354650.1	STKc_CASK	8..307	CDD:270996	297/304 (98%)
		Calmodulin-binding	305..315		9/9 (100%)
		L27	348..401	CDD:197794	52/52 (100%)
		L27	406..456	CDD:460717	49/49 (100%)
		Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250|UniProtKB:Q62915	482..909		425/466 (91%)
		PDZ_CASK-like	489..569	CDD:467267	79/79 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..610		35/35 (100%)
		SH3_CASK	616..677	CDD:213014	60/60 (100%)
		Guanylate_kin	738..911	CDD:395500	171/212 (81%)
Cask	XP_011245733.1	STKc_CASK	8..313	CDD:270996	297/304 (98%)
		L27	354..407	CDD:197794	52/52 (100%)
		L27	412..462	CDD:460717	49/49 (100%)
		PDZ_CASK-like	495..575	CDD:467267	79/79 (100%)
		SH3_CASK	622..683	CDD:213014	60/60 (100%)
		Guanylate_kin	744..957	CDD:395500	171/212 (81%)