DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment YARS1 and MetRS

DIOPT Version :9

Sequence 1:NP_003671.1 Gene:YARS1 / 8565 HGNCID:12840 Length:528 Species:Homo sapiens
Sequence 2:NP_611382.1 Gene:MetRS / 37177 FlyBaseID:FBgn0034401 Length:1022 Species:Drosophila melanogaster


Alignment Length:391 Identity:81/391 - (20%)
Similarity:146/391 - (37%) Gaps:134/391 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    69 VTILFADLHAYLDNMKAPWELLELR--------VSYYENVIKAMLESIGVPLEKLKFIKGTDYQL 125
            :.::..:|..|:::|    |..:||        :|.:.|   ..::|    .:....:||||.|.
  Fly   674 LALINRELRGYINSM----EKAKLRDGVRHLLAISRHGN---GYMQS----QQPWVLLKGTDDQK 727

Human   126 SKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQ--FGGIDQ 188
            ::..|:....::...                   ||:.||:|        |:...|:  ||.::.
  Fly   728 TRASTIIGLCVNIAC-------------------LLANLLFP--------YMPTTARTLFGQLNA 765

Human   189 RKIFTFAEKYL-------------PALGYSKRVHLMNPMVPGLTG-------------SKMSSSE 227
            ::....|||.|             ||..::|   |....:..|.|             |::|:::
  Fly   766 KQTPLNAEKPLVTLLLPAGHQIGKPAPLFAK---LEQSFIDELKGKYGGAQATNDAAHSQISAAD 827

Human   228 EESKIDL-LDRKEDVKKKLK-KAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYT 290
            .|..:.. .|:..::|...| ||..:|...:           |..||.:   |.:.|   .||.|
  Fly   828 LEKAVQAQADKVRELKASTKDKAIWQPEVTK-----------LLDLKKQ---LEEAK---KKTAT 875

Human   291 AYV---------------DLEKDFAAEVVHPGD----LKNSV------EVALNKLLDPIREKFNT 330
            |..               ||||    .:...||    ||.|.      :..:|.|||   .|...
  Fly   876 AAAPAATPAPSNGSQSVQDLEK----AIQEQGDKVRKLKGSTKDKTVWQPEVNILLD---LKKQL 933

Human   331 PALKKLASAAYPDPSKQKPMAKGPAKNSEPEEV--IPSRLDIRVGKIITVEKHPDADSLYVEKID 393
            .|::|.|.||   |:.....|..||..::..:|  :..::..:..|:.|::...|| :::..::|
  Fly   934 EAVQKAAKAA---PAANAAPAASPAATADAAKVKALEDKIAQQAEKVRTLKATGDA-AVWKPEVD 994

Human   394 V 394
            :
  Fly   995 I 995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
YARS1NP_003671.1 nt_trans 8..328 CDD:320711 65/321 (20%)
'HIGH' region 44..52
'KMSKS' region 222..226 1/3 (33%)
PRK12267 <327..528 CDD:330948 16/70 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..363 6/23 (26%)
MetRSNP_611382.1 GstA 1..175 CDD:223698
GST_N_family 1..65 CDD:238319
GST_C_family 63..164 CDD:295467
PRK12268 254..812 CDD:237029 34/178 (19%)
MetRS_core 255..625 CDD:173907
Anticodon_Ia_Met 634..763 CDD:153411 24/126 (19%)
MetRS_RNA 828..868 CDD:238475 11/53 (21%)
MetRS_RNA 895..938 CDD:238475 14/49 (29%)
MetRS_RNA 966..1009 CDD:238475 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0143
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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