DRSC/TRiP Functional Genomics Resources

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Protein Alignment YARS1 and MetRS

DIOPT Version :10

Sequence 1:NP_003671.1 Gene:YARS1 / 8565 HGNCID:12840 Length:528 Species:Homo sapiens
Sequence 2:NP_611382.1 Gene:MetRS / 37177 FlyBaseID:FBgn0034401 Length:1022 Species:Drosophila melanogaster


Alignment Length:391 Identity:81/391 - (20%)
Similarity:146/391 - (37%) Gaps:134/391 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    69 VTILFADLHAYLDNMKAPWELLELR--------VSYYENVIKAMLESIGVPLEKLKFIKGTDYQL 125
            :.::..:|..|:::|    |..:||        :|.:.|   ..::|    .:....:||||.|.
  Fly   674 LALINRELRGYINSM----EKAKLRDGVRHLLAISRHGN---GYMQS----QQPWVLLKGTDDQK 727

Human   126 SKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQ--FGGIDQ 188
            ::..|:....::...                   ||:.||:|        |:...|:  ||.::.
  Fly   728 TRASTIIGLCVNIAC-------------------LLANLLFP--------YMPTTARTLFGQLNA 765

Human   189 RKIFTFAEKYL-------------PALGYSKRVHLMNPMVPGLTG-------------SKMSSSE 227
            ::....|||.|             ||..::|   |....:..|.|             |::|:::
  Fly   766 KQTPLNAEKPLVTLLLPAGHQIGKPAPLFAK---LEQSFIDELKGKYGGAQATNDAAHSQISAAD 827

Human   228 EESKIDL-LDRKEDVKKKLK-KAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYT 290
            .|..:.. .|:..::|...| ||..:|...:           |..||.:   |.:.|   .||.|
  Fly   828 LEKAVQAQADKVRELKASTKDKAIWQPEVTK-----------LLDLKKQ---LEEAK---KKTAT 875

Human   291 AYV---------------DLEKDFAAEVVHPGD----LKNSV------EVALNKLLDPIREKFNT 330
            |..               ||||    .:...||    ||.|.      :..:|.|||   .|...
  Fly   876 AAAPAATPAPSNGSQSVQDLEK----AIQEQGDKVRKLKGSTKDKTVWQPEVNILLD---LKKQL 933

Human   331 PALKKLASAAYPDPSKQKPMAKGPAKNSEPEEV--IPSRLDIRVGKIITVEKHPDADSLYVEKID 393
            .|::|.|.||   |:.....|..||..::..:|  :..::..:..|:.|::...|| :::..::|
  Fly   934 EAVQKAAKAA---PAANAAPAASPAATADAAKVKALEDKIAQQAEKVRTLKATGDA-AVWKPEVD 994

Human   394 V 394
            :
  Fly   995 I 995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
YARS1NP_003671.1 nt_trans 8..328 CDD:469580 65/321 (20%)
'HIGH' region. /evidence=ECO:0000269|PubMed:14671330 44..52
'KMSKS' region. /evidence=ECO:0000269|PubMed:14671330 222..226 1/3 (33%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22291016 242..247 2/5 (40%)
PLN02610 <327..528 CDD:215329 16/70 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..363 6/23 (26%)
MetRSNP_611382.1 GST_N_5 1..70 CDD:436537
GST_C_family 63..164 CDD:470672
PLN02610 248..>850 CDD:215329 40/216 (19%)
MetRS_RNA 895..938 CDD:238475 14/49 (29%)
MetRS_RNA 966..1009 CDD:238475 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

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