DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YARS1 and AIMP1

DIOPT Version :9

Sequence 1:	NP_003671.1	Gene:	YARS1 / 8565	HGNCID:	12840	Length:	528	Species:	Homo sapiens
Sequence 2:	NP_610426.2	Gene:	AIMP1 / 35892	FlyBaseID:	FBgn0033351	Length:	323	Species:	Drosophila melanogaster

Alignment Length:	268	Identity:	119/268 - (44%)
Similarity:	155/268 - (57%)	Gaps:	47/268 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   294 DLEKDFAAEVVHPGDLKNSVEVALNKLLD------------PIREKFNT-------PALKKLASA 339
            :|.|:.||       |...||.||.:|:.            |....|.|       ||....|:|
  Fly    68 ELIKENAA-------LAKEVEAALAQLVQLELRNGKKQIPVPGARGFCTSAAPVVMPAEAGPATA 125

Human   340 A----YPDPSKQ---------KPMAKGPAKNSE-PEEVIPSRLDIRVGKIITVEKHPDADSLYVE 390
            |    .|.|:|:         ||.|:.||...| |.:|  .|||:|||||:.|.:||||||||:|
  Fly   126 APAAPAPKPAKEPKEKKSKEKKPAAEKPAAAPEAPVDV--GRLDLRVGKIVEVGRHPDADSLYLE 188

Human   391 KIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPL 455
            |||.|||.|||||||||:|||.||:|:|||||:|||||.|||||.|:.|::|||..   .:||.|
  Fly   189 KIDCGEAAPRTVVSGLVKFVPLEEMQNRLVVVMCNLKPAKMRGVTSEAMVMCASTP---EKVEVL 250

Human   456 DPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNF-MTKLGSISC 519
            .||||:.||:.|..:||.: |||.:|.||||:||....|.|.:.|.:|.:|.... :...|::..
  Fly   251 SPPAGAVPGDLVHCEGYPR-QPDAQLNPKKKIFESCAPDLKTNGELVACYKGAALHVPGKGNVVA 314

Human   520 KSLKGGNI 527
            ::||..|:
  Fly   315 QTLKNVNV 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YARS1	NP_003671.1	nt_trans	8..328	CDD:320711	11/45 (24%)
		'HIGH' region	44..52
		'KMSKS' region	222..226
		PRK12267	<327..528	CDD:330948	108/223 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..363		12/37 (32%)
AIMP1	NP_610426.2	tRNA_bind_EMAP-II_like	161..262	CDD:239198	69/105 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D557463at33208
OrthoFinder	1	1.000	-	-		FOG0000771
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820