Protein Alignment YARS1 and AIMP1

DIOPT Version :10

• Sequence 1: NP_003671.1
• Gene: YARS1 / 8565
• HGNCID: 12840
• Length: 528
• Species: Homo sapiens
• Sequence 2: NP_610426.2
• Gene: AIMP1 / 35892
• FlyBaseID: FBgn0033351
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 268
• Identity: 119/268 - (44%)
• Similarity: 155/268 - (57%)
• Gaps: 47/268 - (17%)

Human   294 DLEKDFAAEVVHPGDLKNSVEVALNKLLD------------PIREKFNT-------PALKKLASA 339
            :|.|:.||       |...||.||.:|:.            |....|.|       ||....|:|
  Fly    68 ELIKENAA-------LAKEVEAALAQLVQLELRNGKKQIPVPGARGFCTSAAPVVMPAEAGPATA 125

Human   340 A----YPDPSKQ---------KPMAKGPAKNSE-PEEVIPSRLDIRVGKIITVEKHPDADSLYVE 390
            |    .|.|:|:         ||.|:.||...| |.:|  .|||:|||||:.|.:||||||||:|
  Fly   126 APAAPAPKPAKEPKEKKSKEKKPAAEKPAAAPEAPVDV--GRLDLRVGKIVEVGRHPDADSLYLE 188

Human   391 KIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPL 455
            |||.|||.|||||||||:|||.||:|:|||||:|||||.|||||.|:.|::|||..   .:||.|
  Fly   189 KIDCGEAAPRTVVSGLVKFVPLEEMQNRLVVVMCNLKPAKMRGVTSEAMVMCASTP---EKVEVL 250

Human   456 DPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNF-MTKLGSISC 519
            .||||:.||:.|..:||.: |||.:|.||||:||....|.|.:.|.:|.:|.... :...|::..
  Fly   251 SPPAGAVPGDLVHCEGYPR-QPDAQLNPKKKIFESCAPDLKTNGELVACYKGAALHVPGKGNVVA 314

Human   520 KSLKGGNI 527
            ::||..|:
  Fly   315 QTLKNVNV 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YARS1	NP_003671.1	nt_trans	8..328	CDD:469580	11/45 (24%)
		'HIGH' region. /evidence=ECO:0000269|PubMed:14671330	44..52
		'KMSKS' region. /evidence=ECO:0000269|PubMed:14671330	222..226
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22291016	242..247
		PLN02610	<327..528	CDD:215329	108/223 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..363		12/37 (32%)
AIMP1	NP_610426.2	DUF2968	<23..91	CDD:431707	10/29 (34%)
		PLN02610	<161..304	CDD:215329	87/148 (59%)