DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APM1 and stnB

DIOPT Version :9

Sequence 1:	NP_015064.1	Gene:	APM1 / 855869	SGDID:	S000006180	Length:	475	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_001036318.2	Gene:	stnB / 4379834	FlyBaseID:	FBgn0016975	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	86/448 - (19%)
Similarity:	160/448 - (35%)	Gaps:	133/448 - (29%)

- Green bases have known domain annotations that are detailed below.

Yeast    90 EVLSDYLKTVEEESIRDNFVIIYELLDEVMDYGIPQITETKMLKQYITQKS--FKL--VKSAKKK 150
            |.:::.|....:.:|..::..:.|...::...|:|        .::..|.|  ||:  :.....|
  Fly   825 ERITNKLTKFAQYAIAGDYEGVKEFGSDLKKLGLP--------VEHAPQSSQLFKIGSMNYEDMK 881

Yeast   151 RNATRPPVALTNSVSWRPEGITHKKNEAFLDIVESINMLMTQKGQVLRSEIIGDVKV--NSKLSG 213
            :.:.....||....:.|...:|:|..|..:..|:.|.:....:|::|:.  |..|::  .:.|:|
  Fly   882 QFSVCIEEALFKIPALRERALTYKMEEVQVTAVDEITVEQDFEGKILKQ--IARVRLFFLAFLTG 944

Yeast   214 MPDLKLGIND-----KGIFSKYLDDDTNIPSASATTSDNNTETDKKPSITSSSATNKKKVNIELE 273
            ||.::||:||     |.:..::                     |..|..|...        |.||
  Fly   945 MPTIELGVNDMWRQGKEVVGRH---------------------DIIPVATEEW--------IRLE 980

Yeast   274 DLKFHQCVRLSKFENEKIITFIPPDGKF-DLMNYRLSTTIKP-----------LIWC-------- 318
            .::||..|...::|..:.|.|.|||..: :|:.:|    ::|           ..||
  Fly   981 AVEFHSVVNQKEYERTRTIKFQPPDANYIELLRFR----VRPPKNRELPLQLKATWCVSGNKVEL 1041

Yeast   319 --------------------DVNVQVHSNS------RIEIHCK---AKAQIKRKSTATNVEILIP 354
                                ||:|:.....      |:|.|.:   .|:..:|......:|.::.
  Fly  1042 RADILVPGFTSRKLGQIPCEDVSVRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERILG 1106

Yeast   355 VPDDADTPTFKYSHGSLKYVPEKSAILWKIRSFPGGKE-------YSMSAELGLPSISNNEDGNR 412
            ..|.......:.:.|..||.....||:|:....|  ||       :.:...:.|.|...
  Fly  1107 AVDTLQESLIEVTSGQAKYEHHHRAIVWRCPRLP--KEGQGAYTTHQLVCRMALTSYDQ------ 1163

Yeast   413 TMPKSNAEILKGPVQIKFQIPYFTTSGIQVRYLKI-----NEPKLQYKSYPWVRYITQ 465
             :|...|..    ..::|.:|....|...||.:.:     :||..:|     |||:.:
  Fly  1164 -IPSELAPY----AFVEFTMPATQVSHTTVRSVSVQDSDGDEPPEKY-----VRYLAR 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APM1	NP_015064.1	AP1_Mu_N	3..143	CDD:341439	9/54 (17%)
APM1	NP_015064.1	AP-1_Mu1_Cterm	161..471	CDD:271158	73/373 (20%)
stnB	NP_001036318.2	Trypan_PARP	377..496	CDD:114603
stnB	NP_001036318.2	AP_MHD_Cterm	897..1219	CDD:299401	73/368 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870