Protein Alignment CDK10 and CTK1

DIOPT Version :10

• Sequence 1: XP_011521707.1
• Gene: CDK10 / 8558
• HGNCID: 1770
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_012783.1
• Gene: CTK1 / 853718
• SGDID: S000001622
• Length: 528
• Species: Saccharomyces cerevisiae
• Alignment Length: 345
• Identity: 129/345 - (37%)
• Similarity: 196/345 - (56%)
• Gaps: 43/345 - (12%)

Human    26 PEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLL 90
            |...|.:.||...:.::.::||||||.||:|::|.|:::|||||:|:..|::|.||:|:|||.||
Yeast   170 PVSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLL 234

Human    91 LRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
            ....|||:..:||::|.:. ::::::..|.:.||:.||.|.....|.:|.|.:..|:|.|::|||
Yeast   235 QSFDHPNVSTIKEIMVESQ-KTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLH 298

Human   156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSI 220
            .|.|:|||:|.||:|:.::|.:|..||||||...... ..|.:|:|||||.||||||||...|.:
Yeast   299 DNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRA-DYTNRVITLWYRPPELLLGTTNYGTEV 362

Human   221 DMWVSKGLAAVRSSVPRAGGVSRRLAAVRSTVLCRAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 285
            |||                                ..||:|.||.....:..|::|:.||:.|.:
Yeast   363 DMW--------------------------------GCGCLLVELFNKTAIFQGSNELEQIESIFK 395

Human   286 LLGTPSENIWPGFSKLP----LVGQYSLRKQPYNNLKHKFPWL--SEAGLRLLHFLFMYDPKKRA 344
            ::|||:.|.||....:|    ::.|.:.:.  .||...||..:  |...|:|...|..||..||.
Yeast   396 IMGTPTINSWPTLYDMPWFFMIMPQQTTKY--VNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRF 458

Human   345 TAGDCLESSYFKEKPLPCEP 364
            :|.:.|:|.||||:|.| ||
Yeast   459 SATEALQSDYFKEEPKP-EP 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK10	XP_011521707.1	STKc_CDK10	31..371	CDD:173742	127/340 (37%)
CTK1	NP_012783.1	STKc_CDK9_like	183..469	CDD:270832	117/321 (36%)