Protein Alignment CDK10 and Cdk9

DIOPT Version :10

• Sequence 1: XP_011521707.1
• Gene: CDK10 / 8558
• HGNCID: 1770
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_477226.2
• Gene: Cdk9 / 37586
• FlyBaseID: FBgn0019949
• Length: 404
• Species: Drosophila melanogaster
• Alignment Length: 344
• Identity: 127/344 - (36%)
• Similarity: 185/344 - (53%)
• Gaps: 45/344 - (13%)

Human    33 CRSVKEFEKLNRIGEGTYGIVYRARDTQ-TDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHP 96
            |....::||:.:||:||:|.|::||:.: ..:.||:|||.||.||:|.||::||||.:|..|:|.
  Fly    44 CDESNKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHE 108

Human    97 NIVELKEV------VVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
            |:|.|.|:      ....:..:.:||..:||.|||.||.||...||..::|.::.|:|.||.|:|
  Fly   109 NVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIH 173

Human   156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKP----MTPKVVTLWYRAPELLLGTTTQ 216
            .|.|:|||:|.:|:|:|..|.:|.||||||||:.:|...    .|.:|||||||.||||||....
  Fly   174 SNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRYTNRVVTLWYRPPELLLGDRNY 238

Human   217 TTSIDMWVSKGLAAVRSSVPRAGGVSRRLAAVRSTVLCRAVGCILAELLAHRPLLPGTSEIHQID 281
            ...:|||                                ..|||:||:....|::.|.:|..|:.
  Fly   239 GPPVDMW--------------------------------GAGCIMAEMWTRSPIMQGNTEQQQLT 271

Human   282 LIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWL-SEAGLRLLHFLFMYDPKKRA 344
            .|.||.|:.:.::|||..:|.|.....|.|.....:|.:. |:: .:.|..||..|...|||||.
  Fly   272 FISQLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVKDQTGCDLLDKLLTLDPKKRI 336

Human   345 TAGDCLESSYFKEKPLPCE 363
            .|...|...:|...|:|.:
  Fly   337 DADTALNHDFFWTDPMPSD 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK10	XP_011521707.1	STKc_CDK10	31..371	CDD:173742	127/344 (37%)
Cdk9	NP_477226.2	STKc_CDK9	37..347	CDD:270848	124/334 (37%)