Protein Alignment CDK10 and cdk11

DIOPT Version :10

• Sequence 1: XP_011521707.1
• Gene: CDK10 / 8558
• HGNCID: 1770
• Length: 392
• Species: Homo sapiens
• Sequence 2: NP_595739.1
• Gene: cdk11 / 2540799
• PomBaseID: SPBC18H10.15
• Length: 398
• Species: Schizosaccharomyces pombe
• Alignment Length: 367
• Identity: 148/367 - (40%)
• Similarity: 206/367 - (56%)
• Gaps: 50/367 - (13%)

Human    26 PEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLL 90
            ||  |..|.|:.::|.|.:|.||:||||||..|..|:.:|||||::.|....|.||:|||||..|
pombe    63 PE--LKSCNSIDDYEILEKIEEGSYGIVYRGLDKSTNTLVALKKIKFDPNGIGFPITSLREIESL 125

Human    91 LRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
            ..:||.|||||::||||..|:.::|||.:.|.||.:||:|||..|.:::||.::||:|....::|
pombe   126 SSIRHDNIVELEKVVVGKDLKDVYLVMEFMEHDLKTLLDNMPEDFLQSEVKTLMLQLLAATAFMH 190

Human   156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSI 220
            .::.:|||||.|||||.:.|.:|.|||||||....|...:|..||||||||||||||..:....|
pombe   191 HHWYLHRDLKPSNLLMNNTGEIKLADFGLARPVSEPKSSLTRLVVTLWYRAPELLLGAPSYGKEI 255

Human   221 DMWVSKGLAAVRSSVPRAGGVSRRLAAVRSTVLCRAVGCILAELLAHRPLLPGTSEIHQIDLIVQ 285
            |||                                ::|||.||::...||..|.||:.|:..|..
pombe   256 DMW--------------------------------SIGCIFAEMITRTPLFSGKSELDQLYKIFN 288

Human   286 LLGTPSENIWPGFSKLPLVGQYSLRKQP----YNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATA 346
            |||.|:...||.:..||...:.   |.|    ::.::...|.|:.....||:.|...:|.||.:|
pombe   289 LLGYPTREEWPQYFLLPYANKI---KHPTVPTHSKIRTSIPNLTGNAYDLLNRLLSLNPAKRISA 350

Human   347 GDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSK 388
            .:.||..||.|.|.|.:|:..|||         |:.::|:||
pombe   351 KEALEHPYFYESPRPKDPKFFPTF---------PSKAKGESK 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK10	XP_011521707.1	STKc_CDK10	31..371	CDD:173742	140/343 (41%)
cdk11	NP_595739.1	STKc_CDC2L1	68..359	CDD:173741	132/325 (41%)