DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDC14B and Pten

DIOPT Version :9

Sequence 1:	XP_016870731.1	Gene:	CDC14B / 8555	HGNCID:	1719	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	74/293 - (25%)
Similarity:	118/293 - (40%)	Gaps:	70/293 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   209 EKAENGDLNWIIPDRFIAFCGPHS-------RARLESGYHQHSPETYIQYFKNHNVTTIIRLNKR 266
            ||..:.||.: |.|..||...|..       |.|||..: :...|.:.|::|.:|:     .::|
  Fly    25 EKGYDLDLTY-INDNIIAMGYPAPDKLEGLFRNRLEDVF-KLLEENHAQHYKIYNL-----CSER 82

Human   267 MYDAKRFTDA----GFDHHDLFFADGSTPTDAIVKEFLD-----ICENAEGAIAVHCKAGLGRTG 322
            .||..:|...    .||.|       :.||..:::.|..     :.|::...:|||||||.||||
  Fly    83 SYDVAKFRGRVAVYPFDDH-------NPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTG 140

Human   323 TLIACY-IMKHYRMTAAETIAWV----RICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQE 382
            |:|..| :....:.:|.|.:||.    ...|.|..|..|::::           .||.:.:...
  Fly   141 TMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYV-----------QYFSKLVCSS- 193

Human   383 NGQHRAAFSKLLSGVDDISING---VENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNA 444
                 ..:||:...|.:|..:.   |:|....|.......|......:.|||:.|....|
  Fly   194 -----VPYSKVSLNVCEIRFSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQ----- 248

Human   445 IPLTVILQSSVQSCKTSEPNISGSA--GITKRT 475
                   :|.|.:.|.|.| :||..  .:||::
  Fly   249 -------KSFVLTIKPSIP-VSGDVKFELTKKS 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC14B	XP_016870731.1	CDC14_N	52..190	CDD:350495
CDC14B	XP_016870731.1	CDC14_C	199..372	CDD:350349	50/183 (27%)
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	35/121 (29%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	22/91 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910