DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDC14B and cdc-14

DIOPT Version :9

Sequence 1:	XP_016870731.1	Gene:	CDC14B / 8555	HGNCID:	1719	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_001300510.1	Gene:	cdc-14 / 173945	WormBaseID:	WBGene00000383	Length:	709	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	187/514 - (36%)
Similarity:	285/514 - (55%)	Gaps:	100/514 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    39 PRRRDPQDDVYLD-ITDRLCFAILYSRP-------KSASNVHYFSIDNELEYENFYADFGPLNLA 95
            |||.:..::...: :.:||.|. .:..|       ||.....:.:|:|:..||.||.||||.||:
Worm     7 PRRNNTIENTLTELLPNRLYFG-CFPNPDAIDKSDKSVKKTCFININNKFHYEPFYEDFGPWNLS 70

Human    96 MVYRYCCKINKKLKSITMLRKKIVHF-----TGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRIL 155
            ::||.|.::.|.|:......:::|.|     ||...:.:.|.|:::|.|::||.|.:.::||..:
Worm    71 VLYRLCVQVGKLLEVEEKRSRRVVLFCQDDGTGQYDKIRVNTAYVLGAYLIIYQGFSADDAYLKV 135

Human   156 IFGET-SYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWI 219
            ..||| .::.||||:.||..:.:.|.|....::||:::|:|:|:.|:.:|||.||:.||||.|||
Worm   136 SSGETVKFVGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLDFSDFDYEEYEFYERVENGDFNWI 200

Human   220 IPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLF 284
            ||.:.::|||||:.:|.|:||..|:|:.|..||:.:.|:||:|||.:.|||.:||.|||||.|||
Worm   201 IPGKILSFCGPHNESREENGYPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLF 265

Human   285 FADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRP 349
            |.|||||:|.|:.:|:.:.:|.:|.:|||||||||||||||||::||.|.:||.|.:.|:|:|||
Worm   266 FIDGSTPSDEIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRP 330

Human   350 GSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQH-------RAAFSKLLSGVDDISI----- 402
            ||||||||.:|:.||...|         ...|.||.|       :....:|::.||||::
Worm   331 GSVIGPQQPYLIEKQKFCW---------SLSQSNGVHLTQNKEEKRNVRRLVNQVDDINLGEERI 386

Human   403 --------------------NG-------------VENQDQQEPEPYSDDDEIN--GVTQGDRLR 432
                                ||             .|::...:|....|:..::  |.:|||||.
Worm   387 SPKSRENTRPNILRRRVQVQNGRSTAPVTIAPAGTSESRRSTKPSRVVDETALDDQGRSQGDRLL 451

Human   433 ALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLVPQ 491
            .||::.|.::                :|:.||             |:|.:..|||..||
Worm   452 QLKAKHQHES----------------ETTSPN-------------SSSSRRFVKSSTPQ 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC14B	XP_016870731.1	CDC14_N	52..190	CDD:350495	48/150 (32%)
CDC14B	XP_016870731.1	CDC14_C	199..372	CDD:350349	99/172 (58%)
cdc-14	NP_001300510.1	DSPn	21..170	CDD:317115	47/149 (32%)
		CDC14	192..347	CDD:225297	92/154 (60%)
		Herpes_BLLF1	<410..>656	CDD:330317	22/101 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I5357
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I1422
Isobase	1	0.950	-	0	Normalized mean entropy	S1763
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1357618at2759
OrthoFinder	1	1.000	-	-		FOG0001645
OrthoInspector	1	1.000	-	-		otm16264
orthoMCL	1	0.900	-	-		OOG6_100917
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R450
SonicParanoid	1	1.000	-	-		X1202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850