DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LGR5 and Lgr4

DIOPT Version :9

Sequence 1:	NP_003658.1	Gene:	LGR5 / 8549	HGNCID:	4504	Length:	907	Species:	Homo sapiens
Sequence 2:	NP_001285192.1	Gene:	Lgr4 / 5740505	FlyBaseID:	FBgn0085440	Length:	809	Species:	Drosophila melanogaster

Alignment Length:	899	Identity:	218/899 - (24%)
Similarity:	316/899 - (35%)	Gaps:	303/899 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    34 CPTHCHCEP-----DGRMLLRVDCSDLGLSELPSNLSVFTSYLD-------------------LS 74
            |.|...|.|     ||    .|||.|.. .|:.....|...|.|                   |.
  Fly    96 CNTTAQCVPQRANCDG----SVDCDDAS-DEVNCVNEVDAKYWDHLYRKQPFGRHDNLRIGECLW 155

Human    75 MN-NIS-------------QL--LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQN 123
            .| |.|             ||  :|..||. ..|..|.|.||....|.:..|:.|..:..|:|:.
  Fly   156 PNENFSCPCRGDEILCRFQQLTDIPERLPQ-HDLATLDLTGNNFETIHETFFSELPDVDSLVLKF 219

Human   124 NQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188
            ..:|.:.:.|...|..                      :.||.|::|||.|..:|...|...:.|
  Fly   220 CSIREIASHAFDRLAD----------------------NPLRTLYMDDNKLPHLPEHFFPEGNQL 262

Human   189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL-----DE 248
            ..:.||.|.:||:....|.||..|..|.|..|||.:...:.|..|.:||.|.||.|:|     |.
  Fly   263 SILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNLEVLYLNENHLKRLDPDR 327

Human   249 FPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN 313
            ||   |||.||..|....|.|..|....|                         ..|.||.|.|.
  Fly   328 FP---RTLLNLHTLSLAYNQIEDIAANTF-------------------------PFPRLRYLFLA 364

Human   314 GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLE--DLPSFSVCQKL 376
            | ::::...|                     :|.|| |.|||.|.|:.|.:|  ||.:|: |.|
  Fly   365 G-NRLSHIRD---------------------ETFCN-LSNLQGLHLNENRIEGFDLEAFA-CLK- 404

Human   377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441
                                  :|.||.|..|:        |.||.|.:..:|:|
  Fly   405 ----------------------NLSSLLLTGNR--------FQTLDSRVLKNLTS---------- 429

Human   442 LHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDL 506
                                      |..|...:.:.|.|
  Fly   430 --------------------------LDYIYFSWFHLCSA------------------------- 443

Human   507 HKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLA 571
                                        |::...|.|.........||||..::|..||.:|.:|
  Fly   444 ----------------------------AMNVRVCDPHGDGISSKLHLLDNQILRGSVWVMASIA 480

Human   572 LTCNALV---------TSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARH 627
            :..|.||         .|.|..| ||:..       :||.:.|.|:...::|..|....|.:.::
  Fly   481 VVGNLLVLLGRYFYKSRSNVEHS-LYLRH-------LAASDFLMGIYLTLIACADISFRGEYIKY 537

Human   628 GAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALL- 691
            ...|.:...|...||||.|:.:||..||||...:|..||....|     |..:.||.|:|..||
  Fly   538 EETWRHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMSVTRPLK-----PRDTEKVRIVLRLLLL 597

Human   692 ---ALTMAAVPLL-----GGSKYGASPLCLPLPFGEPSTMGY---MVALILLNSLCFLMMTIAYT 745
               :..:||.|||     |...||.:.:||.|...:|...|:   .:..||:|:|..:.:..:|.
  Fly   598 WGISFGLAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLFILVNTLSLIFILFSYI 662

Human   746 K-LYCNLDKG--------DLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVI 801
            : |....|.|        ..||:    :....|:::.|:|....|:..:..::|.... |||::.
  Fly   663 RMLQAIRDSGGGMRSTHSGRENV----VATRFAIIVTTDCACWLPIIVVKLAALSGCE-ISPDLY 722

Human   802 KFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSD 855
            .::.::|:|:.:.|||:||.|....||:.|     :.|..|.   ||...:|::
  Fly   723 AWLAVLVLPVNSALNPVLYTLTTAAFKQQL-----RRYCHTL---PSCSLVNNE 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..70	CDD:214470	12/40 (30%)
		leucine-rich repeat	68..91	CDD:275380	11/57 (19%)
		PLN00113	71..>426	CDD:215061	101/396 (26%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		leucine-rich repeat	140..163	CDD:275380	0/22 (0%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	188..211	CDD:275380	9/22 (41%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..258	CDD:275380	13/26 (50%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		leucine-rich repeat	283..304	CDD:275380	0/20 (0%)
		leucine-rich repeat	307..353	CDD:275378	10/45 (22%)
		leucine-rich repeat	354..375	CDD:275378	10/22 (45%)
		leucine-rich repeat	376..389	CDD:275378	0/12 (0%)
		leucine-rich repeat	400..423	CDD:275378	8/22 (36%)
		leucine-rich repeat	445..459	CDD:275378	0/13 (0%)
		7tmA_LGR5	558..831	CDD:320485	85/302 (28%)
		TM helix 1	559..585	CDD:320485	10/34 (29%)
		TM helix 2	592..617	CDD:320485	5/24 (21%)
		TM helix 3	637..667	CDD:320485	14/29 (48%)
		TM helix 4	679..701	CDD:320485	9/25 (36%)
		TM helix 5	721..750	CDD:320485	7/32 (22%)
		TM helix 6	759..789	CDD:320485	4/29 (14%)
		TM helix 7	799..824	CDD:320485	8/24 (33%)
Lgr4	NP_001285192.1	Ldl_recept_a	87..124	CDD:278486	11/32 (34%)
		LRR_RI	<184..397	CDD:238064	78/286 (27%)
		LRR_8	188..248	CDD:290566	19/81 (23%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	238..261	CDD:275380	9/22 (41%)
		LRR_8	261..320	CDD:290566	23/58 (40%)
		leucine-rich repeat	262..285	CDD:275380	9/22 (41%)
		LRR_4	284..325	CDD:289563	15/40 (38%)
		leucine-rich repeat	286..309	CDD:275380	8/22 (36%)
		LRR_4	308..348	CDD:289563	18/42 (43%)
		leucine-rich repeat	310..334	CDD:275380	13/26 (50%)
		leucine-rich repeat	335..357	CDD:275380	6/46 (13%)
		LRR_8	356..416	CDD:290566	28/114 (25%)
		leucine-rich repeat	358..381	CDD:275380	10/45 (22%)
		LRR_4	381..421	CDD:289563	20/71 (28%)
		leucine-rich repeat	382..405	CDD:275380	11/46 (24%)
		leucine-rich repeat	406..427	CDD:275380	9/28 (32%)
		7tm_1	483..741	CDD:278431	75/275 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810