Protein Alignment LGR5 and Con

DIOPT Version :10

• Sequence 1: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 126/495 - (25%)
• Similarity: 193/495 - (38%)
• Gaps: 100/495 - (20%)

Human    19 ATGGSSPRSG----VLLRGCPTHCHCEPDGR--MLLRVDCSDLGLSELPSNLSVFTSYLDLSMNN 77
            :||.|.|...    ...|.....|:|.||..  .:.:.:|            .||:..|.
  Fly    96 STGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAEC------------WVFSEGLH----- 143

Human    78 ISQLLPNPLPSLRFLEELRL-------AGNA-LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134
                 .|.....||.::.||       ..|| |.|||......|.:|..::::.:|:..|.:.|.
  Fly   144 -----QNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAF 203

Human   135 QNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIH 199
            .||..|:.:.|:.|||..:....|:....||.|.|:.|.:.|:...|||:|...:.:.|..|.|.
  Fly   204 ANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNIS 268

Human   200 HIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELG 263
            .:.:..|.:::.|..|:|.:|:|:.|..:.|.||.:|..|.|..|||:.. .|....|.:|.||.
  Fly   269 TLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELE 333

Human   264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTA 328
            ...|.|..|.|:|..|..:|.|::..:|.::.:.....:..|.|.::.:.              |
  Fly   334 LDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQ--------------A 384

Human   329 N-LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVD 392
            | ||:||....|  .:...:.|....|.|.|..:          :|      |.|...|:|:|..
  Fly   385 NKLETLTFYTFQ--PIMDNLVNSTSELLVSDNKF----------IC------DCRLQWIFELKNR 431

Human   393 T--FQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLD---------LSSNLLS------SFPIT 440
            |  .|...||..|:....:..:.|  ....:|..| ||         :.||..|      |...:
  Fly   432 TRHLQLRDSLEDLHCTLQEPKLSH--FVDPVPPTI-LDVLNIGGFTAIGSNSASMGGVGNSVVGS 493

Human   441 GLHGLT------HLKLTGNHAL----QSLISSENFPELKV 470
            ...|||      ||......||    |...|:||..|.|:
  Fly   494 SYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKM 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	5/33 (15%)
		leucine-rich repeat	68..91	CDD:275380	2/22 (9%)
		LRR	92..477	CDD:443914	110/416 (26%)
		leucine-rich repeat	92..115	CDD:275380	9/30 (30%)
		leucine-rich repeat	116..139	CDD:275380	6/22 (27%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..258	CDD:275380	8/22 (36%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		leucine-rich repeat	283..304	CDD:275380	3/20 (15%)
		leucine-rich repeat	307..353	CDD:275378	9/46 (20%)
		leucine-rich repeat	354..375	CDD:275378	4/20 (20%)
		leucine-rich repeat	376..389	CDD:275378	3/12 (25%)
		leucine-rich repeat	400..423	CDD:275378	3/22 (14%)
		leucine-rich repeat	445..459	CDD:275378	7/23 (30%)
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
Con	NP_523930.3	LRR	<157..459	CDD:443914	89/335 (27%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)