Protein Alignment LGR5 and CG7509

DIOPT Version :10

• Sequence 1: NP_003658.1
• Gene: LGR5 / 8549
• HGNCID: 4504
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_647931.1
• Gene: CG7509 / 38579
• FlyBaseID: FBgn0035575
• Length: 615
• Species: Drosophila melanogaster
• Alignment Length: 448
• Identity: 124/448 - (27%)
• Similarity: 179/448 - (39%)
• Gaps: 94/448 - (20%)

Human    18 LATGG----SSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSN--LSVFTSYLDLSMN 76
            ||||.    :...|||        |.|.||.:..   .|.:..|..:|..  :.:....:|||.|
  Fly   138 LATGSQIEWNHCTSGV--------CRCNPDTKSF---TCWNTNLKSVPVTQVIPMNMVNIDLSRN 191

Human    77 NISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
            .:|.|..:....|..|:||.::.|.|.::|...|..|.||.||.:|||||..:.......||:|.
  Fly   192 ILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLN 256

Human   142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAF 206
            .|.|..|.|..:|.|.|  .|:.|
  Fly   257 ILDLSKNEIGMLPESIF--YHAQR----------------------------------------- 278

Human   207 GNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIR 270
                 |.|:::.:|:|.:...........||.||::.|.:.|..: :||.|:.||.|.|..|.|.
  Fly   279 -----LTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIA 338

Human   271 SIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTL 335
            .|.:..|.|..||.|:..::|.|..:..:.|.:|                       |||.:|.|
  Fly   339 KIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL-----------------------ANLVTLDL 380

Human   336 TGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLL 398
            |..:||.:......:|.||..|.|..|.:..:|:  |.....|.::.|..|.:..::.|.||.|.
  Fly   381 TTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN 445

Human   399 SLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHL---KLTGN 453
            :|:.|.|..|.:......||..|..|.||.:.||.|...|...||||.:|   ||..|
  Fly   446 NLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKN 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LGR5	NP_003658.1	LRRNT	33..65	CDD:396168	7/33 (21%)
		leucine-rich repeat	68..91	CDD:275380	7/22 (32%)
		LRR	92..477	CDD:443914	103/368 (28%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		leucine-rich repeat	140..163	CDD:275380	8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	1/22 (5%)
		leucine-rich repeat	188..211	CDD:275380	0/22 (0%)
		leucine-rich repeat	212..235	CDD:275380	4/22 (18%)
		leucine-rich repeat	236..258	CDD:275380	9/22 (41%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		leucine-rich repeat	307..353	CDD:275378	9/45 (20%)
		leucine-rich repeat	354..375	CDD:275378	6/22 (27%)
		leucine-rich repeat	376..389	CDD:275378	3/12 (25%)
		leucine-rich repeat	400..423	CDD:275378	7/22 (32%)
		leucine-rich repeat	445..459	CDD:275378	5/12 (42%)
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
CG7509	NP_647931.1	LRR	185..>437	CDD:443914	84/322 (26%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		leucine-rich repeat	255..278	CDD:275380	9/24 (38%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		leucine-rich repeat	303..326	CDD:275380	9/22 (41%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		leucine-rich repeat	351..374	CDD:275380	6/45 (13%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	11/22 (50%)
		PCC	476..>561	CDD:188093	12/28 (43%)