DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LGR5 and rk

DIOPT Version :9

Sequence 1:NP_003658.1 Gene:LGR5 / 8549 HGNCID:4504 Length:907 Species:Homo sapiens
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:984 Identity:283/984 - (28%)
Similarity:434/984 - (44%) Gaps:134/984 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    17 QLAT--------GGSSPRSGVLLRGCPTHCHCEPDGRM-LLRVDCSDLGLSELPSNLSVFTSYLD 72
            ||:|        .|......:..|....||||  .|.: :||:.|..:|:..:|.||......||
  Fly   123 QLSTASTATDVIAGKRTLHSICERWLQKHCHC--TGSLEVLRLSCRGIGILAVPVNLPNEVVVLD 185

Human    73 LSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNL 137
            |..||:::|..|.......||||.|:.|::..:...||.||..||.|.|||..|:.:|.::.|.|
  Fly   186 LGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGL 250

Human   138 RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
            ..|.||:|:.|.:..:...|...|..||.|.|:.|....||..|...|..|:|:.|..|.:..|.
  Fly   251 AQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN 315

Human   203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSN 267
            |..|..:.:|:||.|..|:|..:.......|.:|:.|:|:.|.:...|..:..||.|:||...||
  Fly   316 DEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSN 380

Human   268 NIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332
            .:|.|.:.....:..::.:.  .||:..:...||:.:.:||.|.|:....:..||:|.....||.
  Fly   381 RLRWINDTELPRSMQMLDMR--ANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEI 443

Human   333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIK------- 390
            |.|..|.|..:|..:|.|.|.|:.|:|..|.|:.:|:.|.|:.|:.:||..|:|.:|:       
  Fly   444 LKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGL 508

Human   391 -----------------VDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
                             .|.||.:..|:.|:|..|:|:.||..|||...:|..|:|.:|:....|
  Fly   509 KQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573

Human   439 ITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAF--------------------- 482
            .:||..|.|||...|..|:.....:.||.::.:.:.|||.||||                     
  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638

Human   483 ----------------GVCENAYKISNQ--------WNKGDNSSMDDLHKKDAG------MFQAQ 517
                            .:....:.:|.|        |....|.:.:.|..:..|      |.:..
  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYF 703

Human   518 DERDL-------------------EDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIG 563
            :|.|:                   |||         ...||||.|.||||.||..|.|.|.:|.|
  Fly   704 EEHDVSGPATGYGFGTGLFSGMSTEDF---------QPGSVQCLPMPGPFLPCADLFDWWTLRCG 759

Human   564 VWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHG 628
            ||.:.:|:|..|..|...:..|...:...:.|:..:||.:...|:...:||.|||.|.|.|....
  Fly   760 VWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFA 824

Human   629 AWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLAL 693
            ..|:..|.|.:.|||::.:||.||:.|.:..|||.:::.::.....:........|:.:..:.||
  Fly   825 IPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFAL 889

Human   694 TMAAVPLLGGSKYGASPLCLPLPFGE-PSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLE 757
            .||.:||:|.|.|....:|||..... |:::.|:::|:.:|...||.:...|.|:|..:......
  Fly   890 IMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAW 954

Human   758 NIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYIL 822
            |..|..:.|.:|||:||:.:...|:||.|.:::..|..||.|..|...:.|:||.:|.||.||.:
  Fly   955 NTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAI 1019

Human   823 FNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPS 887
            ....||:|.|:|         .||     .....|........:..|..|...   ||||..:|:
  Fly  1020 MTKQFKKDCVTL---------CKH-----FEESRVVGGGGPGGRGAVARTKRG---DLPPPLLPA 1067

Human   888 PAYPVTESC 896
            .|......|
  Fly  1068 AAVAHPPGC 1076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR5NP_003658.1 LRRNT 33..70 CDD:214470 12/37 (32%)
leucine-rich repeat 68..91 CDD:275380 7/22 (32%)
PLN00113 71..>426 CDD:215061 120/378 (32%)
leucine-rich repeat 92..115 CDD:275380 10/22 (45%)
leucine-rich repeat 116..139 CDD:275380 10/22 (45%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
leucine-rich repeat 164..187 CDD:275380 9/22 (41%)
leucine-rich repeat 188..211 CDD:275380 7/22 (32%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..258 CDD:275380 6/21 (29%)
leucine-rich repeat 259..282 CDD:275380 7/22 (32%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
leucine-rich repeat 307..353 CDD:275378 16/45 (36%)
leucine-rich repeat 354..375 CDD:275378 8/20 (40%)
leucine-rich repeat 376..389 CDD:275378 5/12 (42%)
leucine-rich repeat 400..423 CDD:275378 10/22 (45%)
leucine-rich repeat 445..459 CDD:275378 6/13 (46%)
7tmA_LGR5 558..831 CDD:320485 85/273 (31%)
TM helix 1 559..585 CDD:320485 8/25 (32%)
TM helix 2 592..617 CDD:320485 6/24 (25%)
TM helix 3 637..667 CDD:320485 12/29 (41%)
TM helix 4 679..701 CDD:320485 6/21 (29%)
TM helix 5 721..750 CDD:320485 8/28 (29%)
TM helix 6 759..789 CDD:320485 11/29 (38%)
TM helix 7 799..824 CDD:320485 10/24 (42%)
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/20 (35%)
LRR_RI 180..>383 CDD:238064 69/202 (34%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 25/59 (42%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 10/22 (45%)
LRR_8 252..311 CDD:290566 20/58 (34%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
LRR_8 299..359 CDD:290566 18/59 (31%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
LRR_RI 327..567 CDD:238064 71/241 (29%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
LRR_8 370..425 CDD:290566 16/56 (29%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 4/22 (18%)
leucine-rich repeat 418..486 CDD:275380 25/67 (37%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
LRR_8 487..545 CDD:290566 13/57 (23%)
leucine-rich repeat 487..510 CDD:275380 6/22 (27%)
leucine-rich repeat 511..534 CDD:275380 3/22 (14%)
LRR_8 533..589 CDD:290566 21/55 (38%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tm_4 764..>892 CDD:304433 34/127 (27%)
7tm_1 770..1017 CDD:278431 74/246 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20807
Inparanoid 1 1.050 311 1.000 Inparanoid score I2595
Isobase 1 0.950 - 0 Normalized mean entropy S5677
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D171884at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41437
orthoMCL 1 0.900 - - OOG6_106088
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2481
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.680

Return to query results.
Submit another query.