Protein Alignment SCIN and Gel

DIOPT Version :10

• Sequence 1: NP_001106177.1
• Gene: SCIN / 85477
• HGNCID: 21695
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_524865.2
• Gene: Gel / 46008
• FlyBaseID: FBgn0010225
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 278/763 - (36%)
• Similarity: 402/763 - (52%)
• Gaps: 88/763 - (11%)

Human     2 ARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTA--KTSRGFTYHLHF 64
            ||.:.|..||.||:..||::||||..|.|..|::.:|.||.||:::||:|.  |..:..::.:||
  Fly    55 ARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHF 119

Human    65 WLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHV 129
            |||.|.|.||:.||||.|||:||.|.|.|||:||:|.:||..|:||||.|::|:.|||.:|..||
  Fly   120 WLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHV 184

Human   130 LTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVA 194
            .||.....||..|||:|.||..:|.||..|.|.|||||:|.|::||.:.||...:.|:|||...|
  Fly   185 ETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAA 249

Human   195 TGIRYNERKGRSELIVVEEGS---EPSELIKVL--GEKPELPDGGD-DDDIIADISNRKMAKLYM 253
            ..||..:..||:.:.:|::.|   :......||  |...::||... |:|...:.::.....||.
  Fly   250 NQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYK 314

Human   254 VSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQ 318
            ||||||.::|.::.:: |.:.|||.:.||||||.|:.  ||||.||.|..:|:..||..|:|||:
  Fly   315 VSDASGKLKVDIIGQK-PLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLR 376

Human   319 QMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSD--------GFGKVYVTEKVAQIKQIPFDA 375
            ...|...|||..:.||.|:..|||:|..|||...|.        |.|    ::::....:|....
  Fly   377 TKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDELLNDDEIDSVV 437

Human   376 SKLHSSPQMAAQHNMVDDGSGKVE--IWRVENNG--RIQVDQNSYGE---FYGGDCYIILYTY-- 431
            ::|..|...|... |.|.|...:|  ...|...|  .|.|....:.|   ..|...|::.|.|
  Fly   438 TQLKKSGGRAFGF-MPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEA 501

Human   432 ---PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGG--QAVQIRVSQGKEPVHLLSLFKDKPL 491
               ..|.:.|.|.|..|      ::|......:..|.|  ..:.::.:||.||.|...:||.|.|
  Fly   502 NNGDTGSLTYVWHGVKA------SAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLL 560

Human   492 IIYKNGTSKKGGQAPAPPT-RLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSG----- 550
            ..:          ...|.| :||::|..:.|.....||..|::||.|:|.|||    :||
  Fly   561 TSF----------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVL----HSGKSHKI 611

Human   551 YIWVGKGASQEEEKGA-----EYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTS------PL 604
            |||.|.|||..|::.|     :|...|   :..:::||.||:|||..|.|:..|..|      ||
  Fly   612 YIWNGLGASAFEKQAAVDRFSDYWDDV---ELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPL 673

Human   605 LETQAEDHPPRLYGCSNKTGRFV-IEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKK 668
            ||:       ||:.|...:|.|: :||: .::.|:||..||:|||||.::|::|:|...:|.|..
  Fly   674 LES-------RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENG 730

Human   669 ESLKSAKMYLETDPSGRDKRT-PIVIIKQGHEPPTFTGWFLGWDSSKW 715
            :.|.:||:|...:|:.|...| .|:.:.||.||..|...|..||.:.|
  Fly   731 KLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCIN	NP_001106177.1	Actin-severing. /evidence=ECO:0000255	1..363		161/376 (43%)
		gelsolin_S1_like	10..121	CDD:200446	57/112 (51%)
		gelsolin_S2_like	136..225	CDD:200445	37/93 (40%)
		gelsolin_S3_like	246..346	CDD:200448	45/99 (45%)
		Ca(2+)-dependent actin binding	364..715		116/383 (30%)
		gelsolin_S4_like	390..486	CDD:200449	26/109 (24%)
		gelsolin_S5_like	508..598	CDD:200444	38/100 (38%)
		gelsolin_S6_like	613..711	CDD:200447	36/99 (36%)
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	57/112 (51%)
		gelsolin_S2_like	191..283	CDD:200445	36/91 (40%)
		gelsolin_S3_like	307..404	CDD:200448	45/99 (45%)
		ADF_gelsolin	470..558	CDD:472830	23/93 (25%)
		ADF_gelsolin	569..661	CDD:472830	37/98 (38%)
		gelsolin_S6_like	675..774	CDD:200447	37/106 (35%)