Protein Alignment SCIN and fliI

DIOPT Version :10

• Sequence 1: NP_001106177.1
• Gene: SCIN / 85477
• HGNCID: 21695
• Length: 715
• Species: Homo sapiens
• Sequence 2: NP_525097.1
• Gene: fliI / 33110
• FlyBaseID: FBgn0000709
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 219/781 - (28%)
• Similarity: 355/781 - (45%)
• Gaps: 101/781 - (12%)

Human    14 GKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRG-FTYHLHFWLGKECSQDESTA 77
            |:..||.:|.||......:.:..||.||.||.|:||.|.....| ..:.:.||:|.|.:.|:...
  Fly   494 GQLPGLTIWEIENFLPNKIEEVVHGKFYEGDCYIVLKTKFDDLGLLDWEIFFWIGNEATLDKRAC 558

Human    78 AAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHV 142
            |||..|.:.::||.:....||.||.||..|:|.|:..:.|..||      ...|...|.:.::|:
  Fly   559 AAIHAVNLRNFLGARCRTVREEQGDESEQFLSLFETEVIYIEGG------RTATGFYTIEEMIHI 617

Human   143 KGRRVVRATEVPLSWD-------SFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYN 200
            ....:|.|....:..:       |.:....|::||||.||.|.|.........||..:|..|...
  Fly   618 TRLYLVHAYGATIHLEPVAPAITSLDPRHAFVLDLGTHIYIWMGERSKNTLNSKARLMAEKISKT 682

Human   201 ERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGD-DDDIIADISNRKMAKLYMVSDASGSMRV- 263
            |||.:.|:.:..:|.|.:|..:.||...|..|..: ..:.:.:.......:||.|....|.:.:
  Fly   683 ERKNKCEIQLERQGEESAEFWQGLGMTSEEADAAEPPKEHVPEDYQPVQPRLYQVQLGMGYLELP 747

Human   264 TVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQI 328
            .|...|......:|.|:..:|||  ....:|||.||.:....|.||:|.:.|....|:......:
  Fly   748 QVELPEQKLCHTLLNSKHVYILD--CYTDLFVWFGKKSTRLVRAAAVKLSRELFNMMDRPDYALV 810

Human   329 QVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQI----------KQIPFDASKL----H 379
            ..:|||.|..||:..|..| |:..:..|.:  ..:.||:.          ::...|.:.|    .
  Fly   811 MRVPEGNEMQIFRTKFAGW-DEVMAVDFTR--TAKSVAKTGANLTQWARQQETRTDLAALFMPRQ 872

Human   380 SSPQMAAQHNMVDDGSGKVEIWR---VENNGRIQVDQNSYGEFYGGDCYIILYTY---------- 431
            |:..:|....:.::.:..:|:..   :||...:::.:...|.||.|:||:.|..|
  Fly   873 SAMPLAEAEQLEEEWNYDLEMMEAFVLENKKFVRLPEEELGRFYTGECYVFLCRYCIPIEEPENG 937

Human   432 -------------------PRGQI---IYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQ-IRV 473
                               |..:|   :|.|||.||......|..|...:..:::.|:.:: :|:
  Fly   938 SEDGANPAADVSKSSANNQPEDEIQCVVYFWQGRNAGNMGWLTFTFTLQKKFKAMFGEELEVVRI 1002

Human   474 SQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPA-PPTRLFQVRRNLASI-TRIVEVDVDANSLN 536
            .|.:|.:..:|.||.| .||:......|...|.. .|...|.:|.|..:: ||:::::.||..||
  Fly  1003 FQQQENLKFMSHFKRK-FIIHTGKRKDKAHTAKGKSPVEFFHLRSNGGALTTRLIQINPDAVHLN 1066

Human   537 SNDVFVLKLP------QNSG--YIWVGKGASQEEEKGAEYVASVL---KCKTLRI-QEGEEPEE- 588
            |...::|.:|      ..||  |:|:|..|..||.|..:.:|..:   ...:|:| .||:|||.
  Fly  1067 STFCYILHVPFETEDDSQSGIVYVWIGSKACNEEAKLVQDIAEQMFNSPWVSLQILNEGDEPENF 1131

Human   589 FWNSLGGKKDYQTSPLLETQAE-DHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWE 652
            ||.:|||:|.|      :|.|| .:..||:.|||:.|.:.:.|...:|.|||||:||:|:||..|
  Fly  1132 FWVALGGRKPY------DTDAEYMNYTRLFRCSNERGYYTVAEKCADFCQDDLADDDIMILDNGE 1190

Human   653 QIFIWIGKDANEVEKKESLKSAKMYLE----TDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSS 713
            .:|:|:|...:|||.|.:.|||::|::    ..|   ::...:.:..:..|...||..|.||.:.
  Fly  1191 HVFLWMGPRCSEVEVKLAYKSAQVYIQHMRIKQP---ERPRKLFLTMKNKESRRFTKCFHGWSAF 1252

Human   714 K 714
            |
  Fly  1253 K 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCIN	NP_001106177.1	Actin-severing. /evidence=ECO:0000255	1..363		102/358 (28%)
		gelsolin_S1_like	10..121	CDD:200446	38/107 (36%)
		gelsolin_S2_like	136..225	CDD:200445	24/95 (25%)
		gelsolin_S3_like	246..346	CDD:200448	29/100 (29%)
		Ca(2+)-dependent actin binding	364..715		117/421 (28%)
		gelsolin_S4_like	390..486	CDD:200449	26/131 (20%)
		gelsolin_S5_like	508..598	CDD:200444	35/103 (34%)
		gelsolin_S6_like	613..711	CDD:200447	36/101 (36%)
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380
		leucine-rich repeat	31..53	CDD:275380
		LRR	33..405	CDD:443914
		leucine-rich repeat	54..76	CDD:275380
		leucine-rich repeat	77..101	CDD:275380
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..171	CDD:275380
		leucine-rich repeat	172..195	CDD:275380
		leucine-rich repeat	196..220	CDD:275380
		leucine-rich repeat	221..243	CDD:275380
		leucine-rich repeat	244..266	CDD:275380
		leucine-rich repeat	267..289	CDD:275380
		leucine-rich repeat	290..314	CDD:275380
		leucine-rich repeat	315..335	CDD:275380
		leucine-rich repeat	338..360	CDD:275378
		gelsolin_S1_like	491..602	CDD:200446	38/107 (36%)
		gelsolin_like	618..706	CDD:200436	23/87 (26%)
		gelsolin_S3_like	729..828	CDD:200448	29/100 (29%)
		gelsolin_like	920..1015	CDD:200436	19/94 (20%)
		gelsolin_S5_like	1037..1141	CDD:200444	35/103 (34%)
		gelsolin_S6_like	1151..1250	CDD:200447	36/101 (36%)