Protein Alignment GFM1 and MEF1

DIOPT Version :10

• Sequence 1: NP_001295093.1
• Gene: GFM1 / 85476
• HGNCID: 13780
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_013170.1
• Gene: MEF1 / 850758
• SGDID: S000004059
• Length: 761
• Species: Saccharomyces cerevisiae
• Alignment Length: 715
• Identity: 398/715 - (55%)
• Similarity: 514/715 - (71%)
• Gaps: 34/715 - (4%)

Human    45 KIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYT 109
            |:|||||||||||||||.||||||||.||..:|||:|:|.|||.||||:|||::||||||||||.
Yeast    69 KLRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYC 133

Human   110 MW----KDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFL 170
            .|    |:.:.|:||||||:|||||||||||||||||||:|||.|||.||:||:|||:|||||.:
Yeast   134 SWDKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRV 198

Human   171 TFINKLDRMGSNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGHFLRD 235
            |||||:|||||:|.||::|:.|||...||.:|||:|.|.:..|:||||...|||..||.|
Yeast   199 TFINKMDRMGSDPFRAIEQLNSKLKIPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNG----- 258

Human   236 FLPLLWNWDRRSGSQIVRYGEIPAELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKL 300
                          :|:..|.:|..|:....:.||.|||.:|:.|:::.|||||||.|:...:|.
Yeast   259 --------------EIIEKGPVPENLKPLMEEKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKD 309

Human   301 AIRRATLKRSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSS 365
            ||||:|:.||||||.:||||.|.|:||:|||:::||||||||.|.|:    |.|..:.|:  |..
Yeast   310 AIRRSTIARSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTAL----DVSNNEAKV--NLV 368

Human   366 RDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQRLARMHADMMEDVEE 430
            .....||||||||||.|::|||||||.|||.|:||:.|.|.:|.|||::.||.|||:..||||:|
Yeast   369 PAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYITNVKTGKKVKVARLVRMHSSEMEDVDE 433

Human   431 VYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTRE 495
            |.:|:|||.||||||||||||| .:...||.|::|||.|:|:::.|::| |...|||.:.||.:|
Yeast   434 VGSGEICATFGIDCASGDTFTD-GSVQYSMSSMYVPDAVVSLSITPNSK-DASNFSKALNRFQKE 496

Human   496 DPTFKVYFDTENKETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKK 560
            ||||:|.||.|:|||:||||||||||||.:|:.|||...|:||||:|::||:||.|..||:||||
Yeast   497 DPTFRVKFDPESKETIISGMGELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKK 561

Human   561 QSGGAGQYGKVIGVLEPLDPEDYTKLE-FSDETFGSNIPKQFVPAVEKGFLDACEKGPLSGHKLS 624
            |||||||||:|||.|.|:|  |.||.. |.....|..||.:::.|..|||.:.||||||.||::.
Yeast   562 QSGGAGQYGRVIGTLSPVD--DITKGNIFETAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVL 624

Human   625 GLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEPIMAVEVVAPNEFQGQVIAGINR 689
            .::.::.|||.|.|||||:||..|...|.:.|...|...|:||||.|.|.:||||||.||..:|:
Yeast   625 DVKMLINDGAIHAVDSNELSFKTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNK 689

Human   690 RHGVITGQDGVEDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKY 754
            ...||...:...|.|||.|:..|:.|||::|.||:.|:||||:::|:|.|.|..|..|:::|:::
Yeast   690 LQAVIQDTENGHDEFTLKAECALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEF 754

Human   755  754
            Yeast   755  754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFM1	NP_001295093.1	FusA	39..754	CDD:440248	398/713 (56%)
MEF1	NP_013170.1	FusA	68..759	CDD:440248	398/715 (56%)