Protein Alignment GFM1 and mef1

DIOPT Version :10

• Sequence 1: NP_001295093.1
• Gene: GFM1 / 85476
• HGNCID: 13780
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_595472.2
• Gene: mef1 / 2539776
• PomBaseID: SPBC1306.01C
• Length: 770
• Species: Schizosaccharomyces pombe
• Alignment Length: 734
• Identity: 394/734 - (53%)
• Similarity: 507/734 - (69%)
• Gaps: 49/734 - (6%)

Human    44 EKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATY 108
            ::||||||||||||||||.|||||||||||..:|||:|||.|||.||.|||||::|||||||||:
pombe    57 KQIRNIGISAHIDSGKTTFTERVLYYTGRIKDIHEVRGKDNVGAKMDFMELEREKGITIQSAATH 121

Human   109 TMW------------------KDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQT 155
            ..|                  |..||||||||||:|||||||||||||||||||||||.|||.||
pombe   122 CTWERTVDQIEANEKQKTDFEKSYNINIIDTPGHIDFTIEVERALRVLDGAVLVLCAVSGVQSQT 186

Human   156 MTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIEE 220
            :||:|||:|||||.::|:||:||||::|.:.:||:.:||...||.:|||:|.|...:|:||||:.
pombe   187 ITVDRQMRRYNVPRISFVNKMDRMGADPWKVIQQINTKLKIPAAAVQIPIGQEDKLEGVVDLIQM 251

Human   221 RAIYFDGDFGHFLRDFLPLLWNWDRRSGSQIVRYGEIPAELRAAATDHRQELIECVANSDEQLGE 285
            ||||..|.                  .|.:|....::|..|...|.:.|..|||.:|:.||::.:
pombe   252 RAIYNRGS------------------KGEKIEISQQVPENLIELAKEKRSALIEKLADLDEEIAD 298

Human   286 MFLEEKIPSISDLKLAIRRATLKRSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNK 350
            :::.|:.|:...|..||||.||.|.||||.:||||.|.|||.:||||.:||||||||:|.| ||.
pombe   299 IYVMEEDPTPEQLMGAIRRTTLARKFTPVLMGSALSNVGVQSVLDAVCDYLPNPSEVENIA-LNA 362

Human   351 EDDSKEKTKILMNSSRDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQ 415
            .|  .||...|:.||   ..|.|.||||||.||||||||:|.|||.||:|:.|||..:.||:::.
pombe   363 AD--SEKPVSLVPSS---EKPLVALAFKLEEGRFGQLTYLRIYQGTLKRGNYIYNVNSTKKIKVS 422

Human   416 RLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPDPVISIAMKPSNKN 480
            ||.|||::.||::|:|.||.|||||||:|||||||||.:.| .:|.|:.||:||||:::||.:|
pombe   423 RLVRMHSNDMEEIEKVEAGGICALFGIECASGDTFTDGSVS-YTMTSMFVPEPVISLSLKPKSK- 485

Human   481 DLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFR 545
            |...|||.:.||.||||||:|..|.|:|||:||||||||||:|.:|:.|||...|.||||:||||
pombe   486 DTTSFSKALNRFQREDPTFRVQLDNESKETIISGMGELHLEVYVERMRREYKVDCETGKPRVAFR 550

Human   546 ETITAPVPFDFTHKKQSGGAGQYGKVIGVLEPLD-PED----YTKLEFSDETFGSNIPKQFVPAV 605
            ||::..|||.:.|||||||||||.||.|.:|.:| .||    ....||.::..|..:|.|::||.
pombe   551 ETLSKKVPFSYLHKKQSGGAGQYAKVEGYIEYMDGVEDESGNVVDCEFINKVTGGTVPTQYIPAC 615

Human   606 EKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEPIMA 670
            ||.|.:|.:||.|.||.:...||||:|||:|.|||:|::|..|...|.:.|...|...:|||||.
pombe   616 EKAFYEALKKGFLIGHPIKNCRFVLEDGAYHPVDSSELAFRLATISAFRTAFLQANPMVLEPIMN 680

Human   671 VEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTME 735
            |.:.||.|.||.||..:::|...|...|..||.|||.|:||||.||.||:::|:.|:||||::||
pombe   681 VSITAPVEHQGGVIGNLDKRKATIVDSDTDEDEFTLQAEVPLNSMFSYSSDIRALTKGKGEFSME 745

Human   736 YSRYQPCLPSTQEDVINKY 754
            :.:|.|.....|:::::.|
pombe   746 FLKYLPAPKYVQKELVDAY 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFM1	NP_001295093.1	FusA	39..754	CDD:440248	393/732 (54%)
mef1	NP_595472.2	FusA	53..768	CDD:440248	394/734 (54%)