Protein Alignment GFM1 and gfm-1

DIOPT Version :10

• Sequence 1: NP_001295093.1
• Gene: GFM1 / 85476
• HGNCID: 13780
• Length: 770
• Species: Homo sapiens
• Sequence 2: NP_496787.1
• Gene: gfm-1 / 174956
• WormBaseID: WBGene00009246
• Length: 750
• Species: Caenorhabditis elegans
• Alignment Length: 772
• Identity: 420/772 - (54%)
• Similarity: 544/772 - (70%)
• Gaps: 35/772 - (4%)

Human     9 VAALGRGRAPASLGWQRKQVNWKACRWSSS---------GVIPNEKIRNIGISAHIDSGKTTLTE 64
            ::.|||..|.|.   .|:|:|....|::|:         ||.|.|:||||||||||||||||:||
 Worm     1 MSPLGRFSAVAQ---SRRQLNNVLRRFASNEAPSSVVVPGVRPIERIRNIGISAHIDSGKTTVTE 62

Human    65 RVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTI 129
            |:|||.|||..||||:|||.|||.||.|:|||||||||||||||..|...||||||||||||||:
 Worm    63 RILYYAGRIDSMHEVRGKDDVGATMDFMDLERQRGITIQSAATYVDWHGTNINIIDTPGHVDFTV 127

Human   130 EVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKL 194
            |||||||||||||||||.|||||.||.|||||:.||||||:.|:||:||.|:.|.:||..:|:||
 Worm   128 EVERALRVLDGAVLVLCGVGGVQSQTFTVNRQLARYNVPFICFVNKMDRNGATPLKALDGLRNKL 192

Human   195 NHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGHFLRDFLPLLWNWDRRSGSQIVRYGEIPA 259
            |||||.:.:|:|.:.||.|||||:|..|:|::|:                   |..|||..|||.
 Worm   193 NHNAALIHLPIGKDSNFNGIVDLVEGHALYYEGE-------------------GGLIVRKDEIPK 238

Human   260 ELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSFTPVFLGSALKNKG 324
            :||..|.|.||||||.:||.||.||||||.::.|::..:..||||..:||:|.||..||||||||
 Worm   239 DLRVEAEDRRQELIEHIANVDETLGEMFLNDQTPNVQQIHEAIRRTVVKRAFVPVLSGSALKNKG 303

Human   325 VQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSSRDNSHPFVGLAFKLEVGRFGQLTY 389
            ||.::::|::|||:||||.|.|.:..|....|| .|:::..|:|..||||||||||.|::|||||
 Worm   304 VQTMINSVVKYLPDPSEVVNRATVKTETTGDEK-GIILSPKRNNDKPFVGLAFKLEAGKYGQLTY 367

Human   390 VRSYQGELKKGDTIYNTRTRKKVRLQRLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKA 454
            .|.|||:|.||||:|.:|..:|||:|||.||||..||::...|||||||.||:||.||:||:...
 Worm   368 FRVYQGQLSKGDTVYASRDGRKVRVQRLVRMHAADMEEITTAYAGDICATFGLDCHSGETFSTDQ 432

Human   455 NSGLSMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELH 519
            |.....||:|:|:||||:|:||.|:.|.:.|.|.:.|||:|||||:..::.|.|||::|||||||
 Worm   433 NLAPHCESMHIPEPVISMAIKPVNRKDADNFIKALTRFTKEDPTFRREYNQEAKETIVSGMGELH 497

Human   520 LEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKKQSGGAGQYGKVIGVLEPLDPEDYT 584
            |||||||::.||.||...|||.||:||.:.:|..|.|.||||:||.||:|::.||::||..:..|
 Worm   498 LEIYAQRMKSEYNCPVELGKPTVAYRECLGSPYKFHFRHKKQTGGQGQFGEIEGVIDPLPSDRNT 562

Human   585 KLEFSDETFGSNIPKQFVPAVEKGFLDA-CEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRA 648
            .:||||||||:||||...||::|| ||| ..:|||...:::|:...:|||:.|.|||.||:.|..
 Worm   563 VVEFSDETFGNNIPKNLFPALKKG-LDAIVAEGPLIKSRIAGIHVRIQDGSTHAVDSTEIAMINT 626

Human   649 GEGALKQALANATLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADVPLN 713
            .:..::::...|...:|||||.||...|.||||.|:..:.:|:.:||..|..|.|.|:..:.||:
 Worm   627 MQNMMRESFEKANWLLLEPIMKVEATVPTEFQGNVVTSLTQRNALITTTDSTEGYATVICEAPLS 691

Human   714 DMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLEATGQL-PVKKGKAK 769
            |||||::||||.||||||::||||||.|.....|:.|..::.:..|.. |.:|||.|
 Worm   692 DMFGYTSELRSLTEGKGEFSMEYSRYAPTTLEAQDRVQAEWRQLHGIADPNEKGKKK 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFM1	NP_001295093.1	FusA	39..754	CDD:440248	404/715 (57%)
gfm-1	NP_496787.1	FusA	37..731	CDD:440248	404/714 (57%)