Protein Alignment AP3B1 and APL6

DIOPT Version :10

• Sequence 1: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Sequence 2: NP_011777.3
• Gene: APL6 / 853177
• SGDID: S000003493
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 825
• Identity: 230/825 - (27%)
• Similarity: 392/825 - (47%)
• Gaps: 100/825 - (12%)

Human    19 ELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASEL---F 80
            |....|||.:..| ::..:|.::.. :.|..:|.|.......||||||:.::|...::.::   |
Yeast    21 EAAAVATSKLGES-SYTYYSQNINP-QQLVTLLNSRNSREVRDAMKRIISIMASDDDSIDVQLYF 83

Human    81 PAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVP 145
            ..||||:.:.:.::|:|:::||:|:||...:|.||||::.|::|.|.|..:|..||..||.:::.
Yeast    84 ADVVKNITTNDTKVKRLIHLYLLRFAENDPNLTLLSINSLQKSLSDSNSELRCFALSALSDMKMS 148

Human   146 IIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDP-EQKEMLIEVIEKLLKDKSTLVAGSVVM 209
            .:.||::..:|:...|.|..||...|.||.|||.... :..|.|::::::|:.|....|....|:
Yeast   149 SLAPIILHTVKKLVTDPSAMVRGEVALAIIKLYRAGKNDYHEELLDILKELMADTDPKVISCAVL 213

Human   210 AFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFY 274
            |::|...|.::|:|.::|:.|.::..::.|.|..:|.:|.:|.:.....|.......|.:.::.
Yeast   214 AYKECYADHLELLHGHFRRYCRIIKQLDSWSQSYLIELLIKYCKQYLPKPTVVDKSSEGSPRSC- 277

Human   275 ESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQ-LYWHISP---KSEAGII 335
             ...|:..:.:........|||..|.:::...|:.|.|..|:::... ||...||   |:...|
Yeast   278 -PLPDKYNEIEYPSYEVVNDPDLDLFLQSLNCLIYSSNPTVILSCCNALYQLASPLQMKNTKFI- 340

Human   336 SKSLVRLL-----RSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTN 395
             ::|||.:     :.|:|   ::||.|..:||..:.:|.||.|.|||...||.:....|::||:.
Yeast   341 -EALVRTVTMTENQGNKE---MLLQAIHFLSILDQTLFLPYTKKFYVFPKDPIVASIWKIQILST 401

Human   396 LANEANISTLLREFQTYVKSQ--DKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLS--NRDEI 456
            |.||:|:..:.:|.:.||.|.  .:......::::.||...........:..|:..:.  |....
Yeast   402 LINESNVKEIFKELKYYVASAHFPENVVIMAVKSLSRCGQLSTSWESHVMKWLIDHMESHNLSAS 466

Human   457 VVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPV-----ARASILWLIGENCERVPKIAPD 516
            |:...|.||:.|:|..|.:|..||   .||.|.:||..     |||.|:||.||......||.||
Yeast   467 VLDAYVNVIRMLVQKNPTKHLRII---FKLADLLTVQTSLADNARAGIVWLFGEIASIEFKICPD 528

Human   517 VLRKMAKSFTSEDDLVKLQILNLGAKLY---LTNSKQTKL----------------------LTQ 556
            |||::.::|::|....:.|||.|.|||.   :.|.||.::                      :..
Yeast   529 VLRRLIQNFSNEGPETRCQILVLSAKLLSYDIDNFKQAQVTGSEENNQNPPYYDFSGSRISQMYN 593

Human   557 YILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGT 621
            .:|.|.|||..:|||||.|.|..|.    .||   ||.....|.|.|.|...|     |.|.:..
Yeast   594 AVLYLAKYDDEFDIRDRARMISSLF----DSG---KYEIVSLLLQAPKPTARS-----DDFIVSA 646

Human   622 L--SHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKKFYSESEEEED 684
            .  :||..||.  :..:..|          |.|:.|:.:    .|...:|.:..|.|::.::...
Yeast   647 RLETHTPEIKE--FFRMLPW----------NTEITEVGE----TGNDIREGAELKDYNKYKKSFS 695

Human   685 SSDSSSDSESESGSESGEQGESG-EEGDSNEDSSEDSSSEQDSESGRESGLEN---------KRT 739
            |....:::.:.|.:.|.....:| .:||||..|.:.:.:...|::|::..|::         :|.
Yeast   696 SQSFITNNSARSFTSSSNAKLTGINDGDSNSISGKGNVNTFTSQNGKKYRLQSLDEFFSDIPERK 760

Human   740 AKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSES 784
            :|.....|...:|.| |.|:|..::||......||:..|||.:.|
Yeast   761 SKPRKIIKVVEESSD-EDEDESEESSDDDEYSDSSLGTSSSGTSS 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/11 (36%)
		Adaptin_N	46..581	CDD:396262	172/581 (30%)
		HEAT repeat	116..144	CDD:293787	11/27 (41%)
		HEAT repeat	150..180	CDD:293787	12/29 (41%)
		HEAT repeat	188..213	CDD:293787	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		32/133 (24%)
		SEEEED	<731..>764	CDD:434218	9/41 (22%)
		AP3B1_C	813..958	CDD:464319
APL6	NP_011777.3	COG5096	6..770	CDD:227427	217/788 (28%)
		HEAT repeat	45..69	CDD:293787	9/23 (39%)
		HEAT repeat	119..146	CDD:293787	11/26 (42%)
		HEAT repeat	153..182	CDD:293787	11/28 (39%)