Protein Alignment AP3B1 and ap3b1a

DIOPT Version :10

• Sequence 1: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Sequence 2: XP_073791871.1
• Gene: ap3b1a / 563316
• ZFINID: ZDB-GENE-031112-8
• Length: 1116
• Species: Danio rerio
• Alignment Length: 1103
• Identity: 746/1103 - (67%)
• Similarity: 878/1103 - (79%)
• Gaps: 55/1103 - (4%)

Human     9 NEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKG 73
            |..||..|..:.|                      |||||:||||||:|.||:||||:||:||.|
Zfish    44 NHTSGNEEKPKRG----------------------NEDLKEMLESNKESLKLEAMKRVVGLIANG 86

Human    74 KNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRV 138
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Zfish    87 KNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRV 151

Human   139 LSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLV 203
            ||||||||||||||||||||:.||||||||.|||||||||||||:|||.||||||||||||||||
Zfish   152 LSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQKEHLIEVIEKLLKDKSTLV 216

Human   204 AGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELED 268
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||:|....::
Zfish   217 AGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFISPWREDAIFDE 281

Human   269 NG-KNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEA 332
            |. |.||:|::   |:...:.|||.||||||||:|||||||||||.||||||.|||||::||.|.
Zfish   282 NSEKTFYDSEE---ERRVDQSKPYIMDPDHRLLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHEI 343

Human   333 GIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLA 397
            .||:|||||||||:|||||:||||||||||||||||||::|||||||||.|.|||||||||||||
Zfish   344 SIITKSLVRLLRSHREVQYVVLQNIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLA 408

Human   398 NEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESV 462
            |||||||:|||||||||||||.|||||||.||||||||.|||||||||||.|||||||.||||||
Zfish   409 NEANISTILREFQTYVKSQDKAFAAATIQAIGRCATNISEVTDTCLNGLVLLLSNRDETVVAESV 473

Human   463 VVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTS 527
            ||||||||.||:||.:||||||||.|:||||:||||||||:||.||.||||||||||||||||||
Zfish   474 VVIKKLLQTQPSQHSDIIKHMAKLFDNITVPMARASILWLMGEYCEHVPKIAPDVLRKMAKSFTS 538

Human   528 EDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSK 592
            |:|:||||.:||.||||||||||||||||||||||||||||||||||||||||||||.|||||||
Zfish   539 EEDIVKLQTVNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSK 603

Human   593 YAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELA 657
            ||::|.:|.||||:|:|.|||||.:||||||||||.:||||||||:||..|||.|||||||:|..
Zfish   604 YARRILMAPKPAPVLQSAFKDRDRYQLGTLSHTLNSQATGYLELSDWPAAAPDQSVRNVEVVEPV 668

Human   658 KE-WTPA-GKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDS 720
            || ..|: ||:|...|.:||||:.||||:..|..|:|| :|.|.|.|:.|||.|.:.|.:.|..|
Zfish   669 KESGAPSLGKSKAGKSKEKFYSDEEEEEEEEDEESNSE-DSSSSSSEESESGSESEENSEVSNKS 732

Human   721 SSEQDSESGRESGLENKRTAKRNSK-AKGKSDSEDGEKEN----------EKSKTSDSSNDESSS 774
            ||.|..:|..||..:.|:..::|.| .:.|.||::.:::|          |....|.||:.||||
Zfish   733 SSSQSEKSSSESDSDKKKKTQKNKKIQQQKPDSKNRKQKNGNAGKSESRSESESGSGSSSSESSS 797

Human   775 IEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLT-----KDVSLLDLDDFNPVSTPVALP 834
            ...|.|.||.||:.:|.::.::.||.|..::|    |:.     |:|||||||||.|  |||..|
Zfish   798 DSGSESGSELESDSDSGTDQKKNTKSKPVQSK----PVVKQVEKKEVSLLDLDDFAP--TPVTTP 856

Human   835 -TPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDK 898
             :..|||||::||:||.:|.:|: :..|:|.|||..::.|||||:||||:..|.|.|||||:...
Zfish   857 KSSILSPSLLSDLQGLSISPTSA-LQASSPVFVPETSYELLHRMTGKGLSGQYRFTRQPCIYDSS 920

Human   899 MVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQ 963
            |||:|:||:|::::.:|||||.:|. .....:|.||.::.|||:.|:|||:|::|.||||.|:||
Zfish   921 MVSLQLTLSNSSEQPLENIHISQKS-SCAQNIHCFNAVERLEPQASVTVSIGVNFNDSTQAANFQ 984

Human   964 LCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVN 1028
            ||||:|.|:|:|||.||||||||:|||.||.:|||.|.||||:||.|..:|:|.:...:.:|||:
Zfish   985 LCTKEDEFSVSIQPAVGELLLPVSMSEADFTREQGKLLGMNESSATITMSPENISSQSVSRKVVS 1049

Human  1029 VANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKPVL 1091
            |||:|.:.|.|:||||||.|||.|.||:||:|.||: ..||:.:||||:|:||:|||:||..|
Zfish  1050 VANLGVISSTQENIHRFAGKTVSSSSLVLVSVTLKD-PDAQITVNTEKSVMGSMLLRQLKTAL 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		5/21 (24%)
		Adaptin_N	46..581	CDD:396262	462/535 (86%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		HEAT repeat	150..180	CDD:293787	26/29 (90%)
		HEAT repeat	188..213	CDD:293787	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		60/160 (38%)
		SEEEED	<731..>764	CDD:434218	10/43 (23%)
		AP3B1_C	813..958	CDD:464319	74/150 (49%)
ap3b1a	XP_073791871.1	None