DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AP3B1 and AP-1-2beta

DIOPT Version :9

Sequence 1:NP_003655.3 Gene:AP3B1 / 8546 HGNCID:566 Length:1094 Species:Homo sapiens
Sequence 2:NP_523415.1 Gene:AP-1-2beta / 32987 FlyBaseID:FBgn0010380 Length:921 Species:Drosophila melanogaster


Alignment Length:1102 Identity:268/1102 - (24%)
Similarity:456/1102 - (41%) Gaps:246/1102 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    42 KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVR 104
            ||.|  :||..|.::|...|.:|:|:::..:..||:.|.|||.||..:.:.|:|:|||||:||:.
  Fly    11 KKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMN 75

Human   105 YAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKN 169
            ||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..|||||.
  Fly    76 YAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKT 140

Human   170 AAHAIQKLYSLDPE--QKEMLIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHKN---Y 226
            ||..:.|||.:...  :.:..::.::.||.|.:.:|..:.|.|..|:   ......|:..|   .
  Fly   141 AAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTI 205

Human   227 RKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPY 291
            .||...|.:..|||||.|:..|..|                        |..|::|.        
  Fly   206 NKLLTALNECTEWGQVFILDSLANY------------------------SPKDEREA-------- 238

Human   292 TMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHI-----SPKSEAGIISKS----LVRLLRSNR 347
                  :.:.....|.|...|||||::..::...:     |.......::|.    ||.||.|..
  Fly   239 ------QSICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSEP 297

Human   348 EVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTY 412
            ||||:.|:||..:..:|..:.:..:|.|:|:..||..:|..||:|:..|||::||:.:|.|.:.|
  Fly   298 EVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEY 362

Human   413 VKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHG 477
            ....|..|....::.|||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|.::.
  Fly   363 ATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYE 427

Human   478 EIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAK 542
            .||..:.:.||::..|.||||::|:|||..||:.. |.::|....:.|..|:..|:||:|....|
  Fly   428 SIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVVK 491

Human   543 LYLTNSKQTKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKP--- 603
            |:|.....|:.|.|::|:|...| .|.|:|||.....:|:..:..:      ||::.||.||   
  Fly   492 LFLKRPSDTQELVQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPAA------AKEVVLADKPLIS 550

Human   604 --APLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKA 666
              ..|||....|.....:.:|:...:...|.::|                               
  Fly   551 EETDLLEPTLLDELICHISSLASVYHKPPTAFVE------------------------------- 584

Human   667 KQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRE 731
                                                                          ||.
  Fly   585 --------------------------------------------------------------GRG 587

Human   732 SGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDS---SNDESSSIEDSSSDSESESEPESESE 793
            :|:       |.|.....:.|..|.::.|.:..|::   .|.||...:..|.|..:.:.|.:.: 
  Fly   588 AGV-------RKSLPNRAAGSAAGAEQAENAAGSEAMVIPNQESLIGDLLSMDINAPAMPSAPA- 644

Human   794 SRRVTKEKEKKTKQDRTPLTKDVSLL--DLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSS 856
                              .|.:|.||  .||..  :..|.|...|..:.||:.|:.||..:|.|.
  Fly   645 ------------------ATSNVDLLGGGLDIL--LGGPPAEAAPGGATSLLGDIFGLGGATLSV 689

Human   857 VISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGE 921
            .:.:....::|.:        .||||.....|.|:     :..|.:.:||.|...:.:.|..|..
  Fly   690 GVQIPKVTWLPAE--------KGKGLEIQGTFSRR-----NGEVFMDMTLTNKAMQPMTNFAIQL 741

Human   922 KKLPIGMKMHVFNPIDS--LEPEGSITVSMGIDFCDSTQTA----SFQLCTKD--DCF------- 971
            .|...|:.  ..:|:.:  |.|..||.|||.:......|..    :.|:..|:  |.|       
  Fly   742 NKNSFGLV--PASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNIDIFYFACLVH 804

Human   972 -NVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNE---TSAVIIAAPQNFTPSVIFQKVVNVA-- 1030
             || :....|:|      .::.|......:...||   |.:.:|.........:....:..:|  
  Fly   805 GNV-LFAEDGQL------DKRVFLNTWKEIPAANELQYTLSGVIGTTDGIASKMTTNNIFTIAKR 862

Human  1031 NVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGS-TAQLIINTEKTVIGSVLLRELKPVL 1091
            ||    .|||.:::....|  :...:|:.::|:.|: .|.|.:.:....:.:::....:.::
  Fly   863 NV----EGQDMLYQSLKLT--NNIWVLLELKLQPGNPEATLSLKSRSVEVANIIFAAYEAII 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP3B1NP_003655.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
Adaptin_N 46..581 CDD:279882 171/552 (31%)
HEAT repeat 116..144 CDD:293787 11/27 (41%)
Cnd1 128..>251 CDD:289487 41/130 (32%)
HEAT repeat 150..180 CDD:293787 11/29 (38%)
HEAT repeat 188..213 CDD:293787 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..292 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..811 15/151 (10%)
SEEEED <729..>764 CDD:291463 8/34 (24%)
AP3B1_C 814..958 CDD:291462 38/147 (26%)
AP-1-2betaNP_523415.1 Adaptin_N 38..535 CDD:279882 165/535 (31%)
HEAT repeat 51..75 CDD:293787 13/23 (57%)
HEAT repeat 87..114 CDD:293787 10/26 (38%)
Cnd1 99..269 CDD:289487 52/207 (25%)
HEAT repeat 121..151 CDD:293787 11/29 (38%)
HEAT repeat 160..186 CDD:293787 6/25 (24%)
HEAT repeat 197..229 CDD:293787 12/31 (39%)
HEAT repeat 393..417 CDD:293787 8/23 (35%)
HEAT repeat 429..458 CDD:293787 13/28 (46%)
HEAT repeat 465..495 CDD:293787 9/29 (31%)
HEAT repeat 506..542 CDD:293787 11/41 (27%)
Alpha_adaptinC2 703..799 CDD:197886 27/102 (26%)
B2-adapt-app_C 809..919 CDD:198088 19/122 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5096
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323029at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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