DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP3B1 and rb

DIOPT Version :9

Sequence 1:	NP_003655.3	Gene:	AP3B1 / 8546	HGNCID:	566	Length:	1094	Species:	Homo sapiens
Sequence 2:	NP_001162664.2	Gene:	rb / 31381	FlyBaseID:	FBgn0003210	Length:	1160	Species:	Drosophila melanogaster

Alignment Length:	1177	Identity:	581/1177 - (49%)
Similarity:	771/1177 - (65%)	Gaps:	115/1177 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     2 SSNSF---PYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAM 63
            :||.|   .|.|:...|...|.|.:      |:.....|.||.:|::||||||:||||..||:||
  Fly     6 ASNPFAMSTYVERPQMGLDVEFGAD------PASGAAFFQSDGRKHDDLKQMLDSNKDGLKLEAM 64

Human    64 KRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 128
            |||:||||:|::||:|||||||||.|||||:||||||||||||||||||||||||||||||||||
  Fly    65 KRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPN 129

Human   129 QLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIE 193
            ||||||||||||||||.:||||:||||::::|||||||||.|||||.||||||.:||:.|:.|||
  Fly   130 QLIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIE 194

Human   194 KLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVS 258
            |||.|::|||.||.||||:||||:|:||||||||||||.|:||:|||||:||:|||||||||||.
  Fly   195 KLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVD 259

Human   259 PWKEGDELEDNG-------KNFYE------------SDDDQKEKTDKKKK--------------- 289
            |..:.::|.::|       :.||:            |.||:|.|:....|
  Fly   260 PNADDEDLVNDGLGETPVSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPS 324

Human   290 -PYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIV 353
             .|.:|.|||||:|.||||||||||:|||||||||.|::||:|..:|:|:|:|||||::|||.:|
  Fly   325 NSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVV 389

Human   354 LQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDK 418
            |..||:||.:||.:|||:||||:||::|||.||.|||:||||||:..:||.:|||||||:.|.|:
  Fly   390 LNCIASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYISSSDR 454

Human   419 QFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHM 483
            .|.|||||.|||||::|.|||:|||:|||.||||.||.||||||||||:|||.:.|:|.|||..|
  Fly   455 SFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTKAAEHFEIITQM 519

Human   484 AKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNS 548
            |||:|.|.||.|||:|:|||||..|:||.|||||||||||||..|.|:||||:||||.||||||.
  Fly   520 AKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKLYLTNP 584

Human   549 KQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVP-NVKSGALSKYAKKIFLAQKPAPLLESPFK 612
            :||.||.||:..|.:||.|||:|||.||:||:|.| :..|..||::|:::|||.||||:.||.::
  Fly   585 EQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTSSVLSQHARQVFLASKPAPVPESKYR 649

Human   613 DRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVI---ELAKEWTPAGKAKQEN---- 670
            |.::||||:|||.||:.|.||.||..:|.:.||.||||:...   :|..|.:|:|.:|.::
  Fly   650 DGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPDSSVRNIAGFMQDKLPGEDSPSGHSKDKSGREG 714

Human   671 -------SAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQ---- 724
                   ..|.|.||       ||..|.:.|||||.|| .|.|..|.||:...|.|...|:
  Fly   715 GKEKGAGGEKGFLSE-------SDDKSSAYSESGSSSG-SGTSDSESDSDGSGSSDEEEEEVQKQ 771

Human   725 -------------DSESGRESGLEN--KRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSS 774
                         |:.|...:...:  |.|...|:.|:|.|.:.|.|         |||....||
  Fly   772 QPTKVSSVKERLIDAGSNELAATSSPVKATINNNNNARGSSGTSDSE---------DSSAYSGSS 827

Human   775 IEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVS-----LLDLDDFNPVSTPVALP 834
            .:||:|.|::|.: ::|:::...||.::.|.|.::.|....|.     ||||||..|:. ||..|
  Fly   828 SDDSASGSDNEVK-KNETKTDTGTKPEKLKEKHEKQPEQTAVKSNLDLLLDLDDIPPIG-PVMTP 890

Human   835 ------TPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPC 893
                  ||. :|.:......|....:.:.:.:..|:.:..|...||:::||.||...|.|.|.|.
  Fly   891 SLGGFLTPG-TPMMAGQAAPLQPQHARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPH 954

Human   894 IFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQ 958
            ::...|.||::...|..:::|..|.:|:..||.||:::.|.||..|:|:.:.:..:|:||.|||.
  Fly   955 LYSSSMCSIELQFQNRGEKEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTH 1019

Human   959 TASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSV-I 1022
            ....:|.:......:.::||||||:..|.:.|...::|:..|.||||....:....|:....| :
  Fly  1020 AVDLELLSSAGSSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVAL 1084

Human  1023 FQKV---VNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLL 1084
            .|||   :|||:..:..|||  :|.||.:|:.|.||:|:|::.|......|::|.||.||||::|
  Fly  1085 RQKVFESINVAHTHSSSSGQ--LHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMVL 1147

Human  1085 RELKPVL 1091
            .||:..|
  Fly  1148 NELRNAL 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		8/31 (26%)
		Adaptin_N	46..581	CDD:279882	381/569 (67%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		Cnd1	128..>251	CDD:289487	94/122 (77%)
		HEAT repeat	150..180	CDD:293787	22/29 (76%)
		HEAT repeat	188..213	CDD:293787	17/24 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..292		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..811		50/178 (28%)
		SEEEED	<729..>764	CDD:291463	8/36 (22%)
		AP3B1_C	814..958	CDD:291462	48/154 (31%)
rb	NP_001162664.2	Adaptin_N	40..621	CDD:279882	386/580 (67%)
		HEAT repeat	48..73	CDD:293787	19/24 (79%)
		HEAT repeat	117..144	CDD:293787	26/26 (100%)
		Cnd1	129..>252	CDD:289487	94/122 (77%)
		HEAT repeat	147..179	CDD:293787	23/31 (74%)
		HEAT repeat	188..214	CDD:293787	17/25 (68%)
		AP3B1_C	881..1019	CDD:291462	41/139 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143298
Domainoid	1	1.000	760	1.000	Domainoid score	I86
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68125
Inparanoid	1	1.050	1002	1.000	Inparanoid score	I295
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54550
OrthoDB	1	1.010	-	-		D147356at33208
OrthoFinder	1	1.000	-	-		FOG0002006
OrthoInspector	1	1.000	-	-		otm41413
orthoMCL	1	0.900	-	-		OOG6_101595
Panther	1	1.100	-	-	LDO	PTHR11134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2031
SonicParanoid	1	1.000	-	-		X1748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940