DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP3B1 and apl6

DIOPT Version :10

Sequence 1:NP_003655.3 Gene:AP3B1 / 8546 HGNCID:566 Length:1094 Species:Homo sapiens
Sequence 2:NP_593796.1 Gene:apl6 / 2541771 PomBaseID:SPAC23H3.06 Length:745 Species:Schizosaccharomyces pombe


Alignment Length:814 Identity:256/814 - (31%)
Similarity:422/814 - (51%) Gaps:100/814 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSSNSFPYNEQSGGGE-ATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMK 64
            ||:.|| :...||..| |.::.:  :|::|       |..:...:.||.::|.||.|:.||:|:.
pombe     1 MSNLSF-FQTLSGLAENAKQIAK--SSSLS-------FEENELSHSDLLRLLNSNSDAGKLEAIN 55

Human    65 RIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQ 129
            .|:..:..|:|.|..||.|||.|||:|.||::||::||::|||...||||||::|.|:.|.|.|.
pombe    56 FILAQMMHGENMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNP 120

Human   130 LIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEK 194
            |.|::|:||:||||||.|..|::|||::...|.:..||::||.||.|.|||||..|..|.|.|:.
pombe   121 LTRSTAIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSLDPSYKSQLEEHIKT 185

Human   195 LLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSP 259
            ||.|.|.:|..:.:..||.|||:::::||..|.::|.|...:.:|.:||.:..|.||||.....|
pombe   186 LLSDNSPIVVPAALFTFEVVCPEKLEIIHPYYHRICTLFPQMNDWDKVVALKTLVRYARLTLPEP 250

Human   260 WKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYW 324
                        :...:..|.||                 |:.:.|....|...:.::|.|:.::
pombe   251 ------------STPSTHSDLKE-----------------LLESIKSCFFSLLPSTIIAGARAFY 286

Human   325 HISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLK 389
            :::|.::..:|.:.|::||.....|:...|:.|:.:..:...:|:.::|||::.::|......||
pombe   287 YLAPSNQMHLIVEPLLQLLLEKPIVRTTTLRYISQIVYKTPELFKNHIKSFFLIASDSDDTCLLK 351

Human   390 LEILTNLANEANISTLLREFQTYVKSQDKQFAAAT-IQTIGRCATNILEVTDTCLNGLVCLLSNR 453
            :.||:.|.:..|.|.:|.|...|:.|......|:| ::.:|..|:..:.:..:|||.|:.||.:.
pombe   352 INILSRLLDAQNSSQILPELLYYINSHPNPSVASTAVKALGDFASANISMAPSCLNTLLLLLKSH 416

Human   454 DEIVVAESVVVIKKLLQMQPAQHGEI-IKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDV 517
            :.::|.|:...::.|:...|.   || ::::|...:::.||.|::..||||.|:...:|::.|||
pombe   417 NSLIVTEAASSLRLLIHNDPK---EIYLQYLAATYETLEVPRAKSVTLWLISEHILIIPRLVPDV 478

Human   518 LRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTK------------LLTQYILNLGKYDQNYDI 570
            ||...|:|..|...||.|||.|..:||:.:..:.|            ||..|:|:|..:|.:||:
pombe   479 LRIAVKTFADETLEVKYQILELSVRLYVLSHSEEKQNDLESRDDVVSLLFNYVLSLIHFDMSYDL 543

Human   571 RDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLE 635
            |||.||.::|     .|...|::.::|.|..|.....|. ...|| :.:||.|..||....||..
pombe   544 RDRARFYKEL-----ASTPSSEFTRRIVLESKGNSQKEI-IASRD-YCIGTASLCLNEDVMGYEP 601

Human   636 LSNWPEVA--PDPSVRNVEVIELAKEWTP----AGKAKQENS-AKKFYSESEEEEDSSDSSSDSE 693
            :.||.:|:  |..|||     |..|:..|    .|.....|| ..|..|....:.|..|:::.:.
pombe   602 IPNWADVSDLPPDSVR-----EGIKDVLPINPHTGNIYSNNSPGVKALSSDNFKRDFGDTNAINR 661

Human   694 SE-SGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEK 757
            .: .|.::.|:..:.|..:|:|...|.|:||.:.|                     ::|....|:
pombe   662 PKFVGQQTLEEFYASETSESSEGEYETSTSESEDE---------------------ETDDTSQEE 705

Human   758 ENEKSKT--SDSSNDESSSIEDSSSDSESESEPE 789
            :|||:.|  .|:.|:.:|||...|......:|||
pombe   706 DNEKNSTPDEDTENNNTSSISTKSIMDRPLTEPE 739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP3B1NP_003655.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31 10/30 (33%)
Adaptin_N 46..581 CDD:396262 187/548 (34%)
HEAT repeat 116..144 CDD:293787 14/27 (52%)
HEAT repeat 150..180 CDD:293787 13/29 (45%)
HEAT repeat 188..213 CDD:293787 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 268..292 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..811 33/136 (24%)
SEEEED <731..>764 CDD:434218 5/32 (16%)
AP3B1_C 813..958 CDD:464319
apl6NP_593796.1 COG5096 1..745 CDD:227427 256/814 (31%)
HEAT repeat 71..95 CDD:293787 15/23 (65%)
HEAT repeat 107..135 CDD:293787 14/27 (52%)
HEAT repeat 141..170 CDD:293787 12/28 (43%)
HEAT repeat 178..204 CDD:293787 9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

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