Protein Alignment AP3B1 and apb-3

DIOPT Version :10

• Sequence 1: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Sequence 2: NP_492170.2
• Gene: apb-3 / 172553
• WormBaseID: WBGene00000163
• Length: 945
• Species: Caenorhabditis elegans
• Alignment Length: 1077
• Identity: 407/1077 - (37%)
• Similarity: 595/1077 - (55%)
• Gaps: 186/1077 - (17%)

Human    35 GLFSSDLKKNEDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVY 99
            |:...:..:..|||.||:||||:.|:||||||:.:|||||:.||||.|||||||:||:|:||||:
 Worm    19 GVILDNRTRFADLKAMLDSNKDNLKVDAMKRIINLIAKGKDVSELFAAVVKNVAAKNVELKKLVF 83

Human   100 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSP 164
            |||||||||||||||||||||||||||||||||.||||||:|||||::.|||:||||:|..|:||
 Worm    84 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRGSALRVLTSIRVPMVAPIMLLAIKDAVRDMSP 148

Human   165 YVRKNAAHAIQKLYSLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKL 229
            ||||.|||||.|||||:||.:..|::.|:.||.|:.:||.||.|.||:|:||.|:||:||::|.|
 Worm   149 YVRKVAAHAIPKLYSLEPELEPQLVDCIDFLLADRRSLVLGSAVYAFDEICPHRLDLLHKHFRAL 213

Human   230 CNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMD 294
            |..|.||:||||:|:|:|||||||.:...|        |.|                     ..|
 Worm   214 CRGLADVDEWGQIVMINMLTRYARHELADP--------DRG---------------------PPD 249

Human   295 PDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIAT 359
            .|..||:.:.:|||||||.:|||||.||::|::||::...|:::||||||..||.||:||.||||
 Worm   250 TDVVLLLNSARPLLQSRNCSVVMAVVQLFYHVAPKAQLSQIARALVRLLRGPRETQYVVLTNIAT 314

Human   360 MSIQR----------KGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVK 414
            :..:.          |.||:|:||||:|||.|.:::|.|||.:||:|.:|||:..:|||.||||.
 Worm   315 ICERNPVEEGTYAISKTMFDPFLKSFFVRSCDSSLVKKLKLHVLTSLVSEANVHIILRELQTYVH 379

Human   415 SQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEI 479
            ..|  .|:..::.|||||..:..|:|.|:.|||.|:|:.||.||..:|||||:||......:  :
 Worm   380 MSD--LASPAVEAIGRCAVRVGAVSDQCMTGLVQLISSSDEKVVCSAVVVIKRLLHASAPLN--L 440

Human   480 IKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLY 544
            :..:.:|:.::....|||.::||:..:.|:|..:|||.||.:||.|::|::||||:.|.|..||:
 Worm   441 LSRLMRLMPNMIAAQARACVIWLVATHVEQVLHMAPDFLRLIAKKFSTENELVKLEALKLAVKLW 505

Human   545 LTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKPAPLLES 609
            |.....::.:.||:..|.::|.:||:|||.||:|.|:   ..:..||::.::||:::||||.|.|
 Worm   506 LVKRDDSEKIVQYVFQLARFDLSYDVRDRCRFLRNLM---FNTEILSQHMEEIFMSKKPAPELIS 567

Human   610 PFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVRNVEVIELAKEWTPAGKAKQENSAKK 674
            .||:||.||||:|||.||.:.|.|::|..:|..:.|..:|.              :|...|..|.
 Worm   568 SFKERDKFQLGSLSHVLNQRCTKYIDLPEFPATSSDSLLRK--------------EAHAPNELKL 618

Human   675 FYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRT 739
            ..|:.||::|..|...|.:.|...|. |:.|..||.:|.|:..:|...|.:.|
 Worm   619 DDSDEEEDDDDEDEEEDEDEEEEDED-EEDEEEEENESEEEEEDDEDEESEEE------------ 670

Human   740 AKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEK--E 802
                      ||.||.|:|.|               :||..:.:...:|.::.::..:.|.|  .
 Worm   671 ----------SDEEDEEEEEE---------------DDSEPEEKPNPKPSTKKQALILNKSKPMN 710

Human   803 KKTKQDRTPLTKDVSLLDLDDFNPVSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVP 867
            .|.|.:|.         |||                   |:.|::          .|.:....:.
 Worm   711 GKPKTERN---------DLD-------------------LLIDVD----------FSAAGSRQIM 737

Human   868 TKTHV------LLHRMSGKGLAAHYFFPRQPCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPI 926
            ..||:      ||:.:.|.||.....:||   |...:..:|:..:.|.||..:..:   |.|...
 Worm   738 DATHIEEKEIELLNVIEGNGLILSISYPR---INDGQYTAIRFGITNKTDGDLLGV---ELKTEE 796

Human   927 GMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQTASFQLCTKDDCF--NVNIQPPVGELLLPVAMS 989
            |:.:...:.|..:.....::|.:.:||.||. |:...:.|:||..  :...:.|.||.:.|:.:|
 Worm   797 GLDVKGNSIIGDIPSGARVSVDLLVDFGDSA-TSREWILTRDDGHEKHFRFEVPYGEQVQPIRLS 860

Human   990 EKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGS 1054
            .:|..||:..|.|:|                   :.|:.:.|    |....:|..|.  ...|..
 Worm   861 PEDISKERSRLGGLN-------------------RHVIQLEN----PINPSSIALFV--NAFSSD 900

Human  1055 LMLVTVELKEGSTAQLIINTEK--------TVIGSVL 1083
            |.:.|.:.:......::..:||        :|||.:|
 Worm   901 LTIFTCQTRSRKDVCILTVSEKSIECCCDNSVIGRML 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Adaptin_N	46..581	CDD:396262	283/544 (52%)
		HEAT repeat	116..144	CDD:293787	25/27 (93%)
		HEAT repeat	150..180	CDD:293787	22/29 (76%)
		HEAT repeat	188..213	CDD:293787	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		35/150 (23%)
		SEEEED	<731..>764	CDD:434218	7/32 (22%)
		AP3B1_C	813..958	CDD:464319	29/150 (19%)
apb-3	NP_492170.2	Adaptin_N	23..546	CDD:396262	284/558 (51%)
		HEAT repeat	100..128	CDD:293787	25/27 (93%)
		HEAT repeat	134..162	CDD:293787	20/27 (74%)
		HEAT repeat	171..197	CDD:293787	12/25 (48%)
		AP3B1_C	<740..826	CDD:464319	21/91 (23%)