Protein Alignment AP3B1 and Ap3b1

DIOPT Version :10

• Sequence 1: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Sequence 2: XP_006517586.1
• Gene: Ap3b1 / 11774
• MGIID: 1333879
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1126
• Identity: 969/1126 - (86%)
• Similarity: 1020/1126 - (90%)
• Gaps: 40/1126 - (3%)

Human     1 MSSNSFPYNEQSGGGEATELGQEATSTISPSGAFGLFSSDLKKNEDLKQMLESNKDSAKLDAMKR 65
            ||||||.||||||||||.||||||||||||||||||||||.||||||||||||||||||||||||
Mouse     1 MSSNSFAYNEQSGGGEAAELGQEATSTISPSGAFGLFSSDWKKNEDLKQMLESNKDSAKLDAMKR 65

Human    66 IVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 IVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 130

Human   131 IRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKL 195
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 IRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEMLIEVIEKL 195

Human   196 LKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPW 260
            ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||
Mouse   196 LKDKSTLVAGSVVMAFEEVCPDRIDLIHRNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPW 260

Human   261 KEGDELEDNGKNFYESDDDQKEK-TDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYW 324
            :|...||||.||||||:::::|| ...:||.|.||||||||||||||||||||||||||||||||
Mouse   261 REDGGLEDNEKNFYESEEEEEEKEKSSRKKSYAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYW 325

Human   325 HISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLK 389
            |||||||||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   326 HISPKSEAGVISKSLVRLLRSNREVQYIVLQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLK 390

Human   390 LEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRD 454
            ||||||||||||||||||||||||:|||||||||||||||||||:|.||||||||||||||||||
Mouse   391 LEILTNLANEANISTLLREFQTYVRSQDKQFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRD 455

Human   455 EIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLR 519
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse   456 EIVVAESVVVIKKLLQMQPAQHGEIIRHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLR 520

Human   520 KMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPN 584
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 KMAKSFTSEDDLVKLQILNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFIRQLIVPN 585

Human   585 VKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEVAPDPSVR 649
            .|||||||||||||||.||||||||||||||.||||||||||||||:||||||||||||||||||
Mouse   586 EKSGALSKYAKKIFLAPKPAPLLESPFKDRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVR 650

Human   650 NVEVIELAKEWTPAGKAKQENSAKKFYSESEEEEDS------------------SDSSSDSESES 696
            ||||||.||||||.||.|:|...||||||||||||.                  |||||||||.|
Mouse   651 NVEVIESAKEWTPLGKTKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGS 715

Human   697 GSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEK 761
            |||||:.|        .|||||||||.||||:|.::..|.::.||||||.|.|||||:.||:||.
Mouse   716 GSESGDTG--------TEDSSEDSSSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNEN 772

Human   762 SKTSDSSNDESSSIEDSSSDSESESEPESESESRRVTKEKEKKTKQDRTPLTKDVSLLDLDDFNP 826
            ||.|:||::||||:|||||:|||||..:||...|.|...||:|.:|:|.|.:|||.|||||||||
Mouse   773 SKASESSSEESSSMEDSSSESESESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLLDLDDFNP 837

Human   827 VSTPVALPTPALSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQ 891
            ||||||||||||||||:||||||:||||||||:||||.|||||||.|||||.||||||||.||||
Mouse   838 VSTPVALPTPALSPSLIADLEGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQ 902

Human   892 PCIFGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDS 956
            ||||.|||||:||||.||:||||||||||.|.||:||:||.|:|||||||:||:|||:|||||||
Mouse   903 PCIFSDKMVSVQITLTNTSDRKIENIHIGGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCDS 967

Human   957 TQTASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKE-------------QGVLTGMNETSA 1008
            |||||||||||||||||.:||||||||.||||||||||||             ||.|||||||||
Mouse   968 TQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGTLTGMNETSA 1032

Human  1009 VIIAAPQNFTPSVIFQKVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIIN 1073
            .:||||||||||:|.||||||||:|||||.|||:|||||:|||||||||||||||||||||||||
Mouse  1033 TLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLMLVTVELKEGSTAQLIIN 1097

Human  1074 TEKTVIGSVLLRELKPVLSQG 1094
            |||||||||||||||||||||
Mouse  1098 TEKTVIGSVLLRELKPVLSQG 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		27/29 (93%)
		Adaptin_N	46..581	CDD:396262	509/535 (95%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		HEAT repeat	150..180	CDD:293787	28/29 (97%)
		HEAT repeat	188..213	CDD:293787	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		92/166 (55%)
		SEEEED	<731..>764	CDD:434218	18/32 (56%)
		AP3B1_C	813..958	CDD:464319	122/144 (85%)
Ap3b1	XP_006517586.1	Adaptin_N	46..582	CDD:396262	509/535 (95%)
		HEAT repeat	116..144	CDD:293787	27/27 (100%)
		HEAT repeat	150..180	CDD:293787	28/29 (97%)
		HEAT repeat	188..213	CDD:293787	24/24 (100%)
		SEEEED	<734..792	CDD:434218	35/57 (61%)
		AP3B1_C	824..969	CDD:464319	122/144 (85%)