Protein Alignment AP3B1 and ap3b1

DIOPT Version :10

• Sequence 1: NP_003655.3
• Gene: AP3B1 / 8546
• HGNCID: 566
• Length: 1094
• Species: Homo sapiens
• Sequence 2: XP_012822818.3
• Gene: ap3b1 / 100493180
• XenbaseID: XB-GENE-987208
• Length: 1097
• Species: Xenopus tropicalis
• Alignment Length: 1110
• Identity: 830/1110 - (74%)
• Similarity: 929/1110 - (83%)
• Gaps: 40/1110 - (3%)

Human     2 SSNSFPYN-EQSGGG--EATELGQEATSTISPSG-----AFGLFSSDLKKNEDLKQMLESNKDSA 58
            :|.:..|| ..||||  |:|||.|||    ||||     .|||||:||||||||||||||||||:
 Frog    11 ASTALTYNHNHSGGGGAESTELAQEA----SPSGNSTPSVFGLFSTDLKKNEDLKQMLESNKDSS 71

Human    59 KLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRA 123
            ||:|||||||||:.|||||||||||||||||||:|||||||||||||||||||||||||:||||.
 Frog    72 KLEAMKRIVGMISDGKNASELFPAVVKNVASKNLEIKKLVYVYLVRYAEEQQDLALLSIATFQRG 136

Human   124 LKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSLDPEQKEML 188
            |||||||||||||||||||||||||||||||||||:|||||||||.||||||||||||||||:||
 Frog   137 LKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAAADLSPYVRKTAAHAIQKLYSLDPEQKDML 201

Human   189 IEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYAR 253
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   202 IEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYAR 266

Human   254 TQFVSPW-KEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVM 317
            .|||||| :|||..|...::|||| |::|:....:|:||.||||||||:||||||||||||||||
 Frog   267 MQFVSPWVEEGDSGEMTTQSFYES-DEEKDADTNQKRPYVMDPDHRLLLRNTKPLLQSRNAAVVM 330

Human   318 AVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDP 382
            ||||||||::||||...::|||:|||||:|||||||||||||:||||||:|||||||||:|||||
 Frog   331 AVAQLYWHLAPKSETSTVAKSLIRLLRSHREVQYIVLQNIATISIQRKGLFEPYLKSFYIRSTDP 395

Human   383 TMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCLNGLV 447
            ||||||||||:||||||||:|||||||||||:||||||||||||.||||||||..||||||||||
 Frog   396 TMIKTLKLEIMTNLANEANVSTLLREFQTYVRSQDKQFAAATIQAIGRCATNISAVTDTCLNGLV 460

Human   448 CLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLIGENCERVPK 512
            .||||||::||||||||||||||.|.:.|.:||:|||||.|.||||:|||||||||||.||||||
 Frog   461 LLLSNRDDVVVAESVVVIKKLLQTQTSHHSDIIRHMAKLFDKITVPMARASILWLIGEYCERVPK 525

Human   513 IAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGKYDQNYDIRDRTRFI 577
            ||||||||.|||||:|||||||||:||..||:||||||||||.|||||||||||||||||||||:
 Frog   526 IAPDVLRKTAKSFTNEDDLVKLQIINLAVKLFLTNSKQTKLLAQYILNLGKYDQNYDIRDRTRFV 590

Human   578 RQLIVPNVKSGALSKYAKKIFLAQKPAPLLESPFKDRDHFQLGTLSHTLNIKATGYLELSNWPEV 642
            :||||||.||||||||||||||||||||:|:|.||||:|||||||||:||.||:||||||:|||:
 Frog   591 KQLIVPNEKSGALSKYAKKIFLAQKPAPVLKSSFKDREHFQLGTLSHSLNTKASGYLELSDWPEI 655

Human   643 APDPSVRNVEVIELAK-EWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGES 706
            ||||||||||..|..| :.|....|..|.|:.||||:|||.|..|:.||::||||..:|..:.||
 Frog   656 APDPSVRNVEPSEPVKNKATKQEMANTEKSSDKFYSDSEEGEKESEESSENESESEEDSDNEKES 720

Human   707 GEEGDSNEDSSEDSSSEQDSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDE 771
                 |:|.|...||:|.:|||...|..|.|..         |.|||| ||:...:|:.|||...
 Frog   721 -----SSEQSDASSSAESESESDESSSKEQKNR---------KKDSED-EKKGTGTKSEDSSVYS 770

Human   772 SSSIEDSSSDSESESEPESESE---SRRVTKEKE---KKTKQDRTPLTKDVSLLDLDDFNPVSTP 830
            ..|.|.:||:|.||||.|||||   |::||..|:   |..||...|...:||||||||||   .|
 Frog   771 EDSSESASSESSSESEEESESEPETSKKVTNSKKTENKPVKQKEIPRKNEVSLLDLDDFN---MP 832

Human   831 VALPTPA-LSPSLMADLEGLHLSTSSSVISVSTPAFVPTKTHVLLHRMSGKGLAAHYFFPRQPCI 894
            .|:..|: |||||::|||||.||:||.||:|.||:|||:|||.||||||||||||.|.||||.||
 Frog   833 AAVAKPSILSPSLLSDLEGLSLSSSSPVINVCTPSFVPSKTHELLHRMSGKGLAAQYHFPRQQCI 897

Human   895 FGDKMVSIQITLNNTTDRKIENIHIGEKKLPIGMKMHVFNPIDSLEPEGSITVSMGIDFCDSTQT 959
            ||.:||::|||.|||||::||:|||.|||:..|:|||.||.||.|||||||||||||||||||||
 Frog   898 FGAQMVTVQITFNNTTDKRIEDIHIEEKKMAAGVKMHAFNQIDYLEPEGSITVSMGIDFCDSTQT 962

Human   960 ASFQLCTKDDCFNVNIQPPVGELLLPVAMSEKDFKKEQGVLTGMNETSAVIIAAPQNFTPSVIFQ 1024
            ||||||||::.|:|.||||.|||||||::||.|||||||.||||||:||.|....:..||.:|.|
 Frog   963 ASFQLCTKENQFSVGIQPPPGELLLPVSLSEADFKKEQGKLTGMNESSATIAVNAEYSTPQIIGQ 1027

Human  1025 KVVNVANVGAVPSGQDNIHRFAAKTVHSGSLMLVTVELKEGSTAQLIINTEKTVIGSVLLRELKP 1089
            :.:..||:|.|.|||:||:||||||||||||||||||||.||.||||||||||||||||||||||
 Frog  1028 RFLQAANLGVVASGQNNIYRFAAKTVHSGSLMLVTVELKGGSAAQLIINTEKTVIGSVLLRELKP 1092

Human  1090 VLSQG 1094
            |||||
 Frog  1093 VLSQG 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP3B1	NP_003655.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		15/31 (48%)
		Adaptin_N	46..581	CDD:396262	462/535 (86%)
		HEAT repeat	116..144	CDD:293787	25/27 (93%)
		HEAT repeat	150..180	CDD:293787	27/29 (93%)
		HEAT repeat	188..213	CDD:293787	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..292		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..811		65/154 (42%)
		SEEEED	<731..>764	CDD:434218	10/32 (31%)
		AP3B1_C	813..958	CDD:464319	103/145 (71%)
ap3b1	XP_012822818.3	Adaptin_N	59..594	CDD:396262	462/535 (86%)
		HEAT repeat	129..157	CDD:293787	25/27 (93%)
		HEAT repeat	163..193	CDD:293787	27/29 (93%)
		HEAT repeat	201..226	CDD:293787	24/24 (100%)
		AP3B1_C	817..961	CDD:464319	103/146 (71%)