DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COB and CYTB

DIOPT Version :9

Sequence 1:	NP_009315.1	Gene:	COB / 854583	SGDID:	S000007270	Length:	385	Species:	Saccharomyces cerevisiae
Sequence 2:	YP_009047277.1	Gene:	CYTB / 19893556	FlyBaseID:	FBgn0013678	Length:	378	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	199/375 - (53%)
Similarity:	270/375 - (72%)	Gaps:	4/375 - (1%)

- Green bases have known domain annotations that are detailed below.

Yeast     4 RKSNVYLSLVNSYIIDSPQPSSINYWWNMGSLLGLCLVIQIVTGIFMAMHYSSNIELAFSSVEHI 68
            |.|:....:.|:.::|.|.|.:|:.|||.||||||||:|||:||:|:||||:::|.|||.||.||
  Fly     6 RNSHPLFKIANNALVDLPAPINISSWWNFGSLLGLCLIIQILTGLFLAMHYTADINLAFYSVNHI 70

Yeast    69 MRDVHNGYILRYLHANGASFFFMVMFMHMAKGLYYGSYR-SPRVTLWNVGVIIFILTIATAFLGY 132
            .|||:.|::||.||||||||||:.:::|:.:|:|||||: :|   .|.:||||..|.:.|||:||
  Fly    71 CRDVNYGWLLRTLHANGASFFFICIYLHVGRGIYYGSYKFTP---TWLIGVIILFLVMGTAFMGY 132

Yeast   133 CCVYGQMSHWGATVITNLFSAIPFVGNDIVSWLWGGFSVSNPTIQRFFALHYLVPFIIAAMVIMH 197
            ...:||||.|||||||||.||||::|.|:|.||||||:|.|.|:.|||..|:::|||:.||.::|
  Fly   133 VLPWGQMSFWGATVITNLLSAIPYLGMDLVQWLWGGFAVDNATLTRFFTFHFILPFIVLAMTMIH 197

Yeast   198 LMALHIHGSSNPLGITGNLDRIPMHSYFIFKDLVTVFLFMLILALFVFYSPNTLGHPDNYIPGNP 262
            |:.||..||:||:|:..|:|:||.|.||.|||:|...:.:.||...|..|||.||.|||:||.||
  Fly   198 LLFLHQTGSNNPIGLNSNIDKIPFHPYFTFKDIVGFIVMIFILISLVLISPNLLGDPDNFIPANP 262

Yeast   263 LVTPASIVPEWYLLPFYAILRSIPDKLLGVITMFAAILVLLVLPFTDRSVVRGNTFKVLSKFFFF 327
            |||||.|.||||.|..||||||||:||.|||.:..:|.:|::|||.:.|..||..|..:::..|:
  Fly   263 LVTPAHIQPEWYFLFAYAILRSIPNKLGGVIALVLSIAILMILPFYNLSKFRGIQFYPINQVMFW 327

Yeast   328 IFVFNFVLLGQIGACHVEVPYVLMGQIATFIYFAYFLIIVPVISTIENVL 377
            ..:...:||..|||..||.||||:|||.|.:||.|:|:...:....:|:|
  Fly   328 SMLVTVILLTWIGARPVEEPYVLIGQILTVVYFLYYLVNPLITKWWDNLL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COB	NP_009315.1	CYTB	10..366	CDD:214440	195/356 (55%)
CYTB	YP_009047277.1	CYTB	12..367	CDD:214440	195/357 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346804
Domainoid	1	1.000	248	1.000	Domainoid score	I350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I289
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60605
OrthoFinder	1	1.000	-	-		FOG0004155
OrthoInspector	1	1.000	-	-		otm46878
orthoMCL	1	0.900	-	-		OOG6_102198
Panther	1	1.100	-	-	LDO	PTHR19271
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R280
SonicParanoid	1	1.000	-	-		X1779
TreeFam	0	0.000	Not matched by this tool.
	12	11.930