DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UNK and unk

DIOPT Version :9

Sequence 1:	XP_016880736.1	Gene:	UNK / 85451	HGNCID:	29369	Length:	839	Species:	Homo sapiens
Sequence 2:	NP_001303430.1	Gene:	unk / 42738	FlyBaseID:	FBgn0004395	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	310/797 - (38%)
Similarity:	413/797 - (51%)	Gaps:	185/797 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    65 YLKEFRTEQCPLFVQHKCTQHRPYTCFHWHFVNQRRRRSIRRRDGTFNYSPDVYCTKYDEATGLC 129
            ||||||.|||..|:||||.||||:.||:|||.||||||.:|:||||||||.|.|||||||.||:|
  Fly    23 YLKEFRVEQCQSFLQHKCNQHRPFVCFNWHFQNQRRRRPVRKRDGTFNYSADNYCTKYDETTGIC 87

Human   130 PEGDECPFLHRTTGDTERRYHLRYYKTGICIHETDSKGNCTKNGLHCAFAHGPHDLRSPVYDIRE 194
            |||||||:||||.||||||||||||||.:|:|:|||:|.|.|||||||||||..|.|.|||||:|
  Fly    88 PEGDECPYLHRTAGDTERRYHLRYYKTCMCVHDTDSRGYCVKNGLHCAFAHGMQDQRPPVYDIKE 152

Human   195 LQAMEALQNGQTTVEGSIEGQSAGAASHAMIEK-ILSEEPRWQETAYVLGNYKTEPCKKPPRLCR 258
            |   |.|||.::|::      |..|.:....|: :::|:|:||:|.|||.||||||||:||||||
  Fly   153 L---ETLQNAESTLD------STNALNALDKERNLMNEDPKWQDTNYVLANYKTEPCKRPPRLCR 208

Human   259 QGYACPYYHNSKDRRRSPRKHKYRSSPCPNVKHGDEWGDPGKCENGDACQYCHTRTEQQFHPEIY 323
            ||||||.||||||:||||||:||||:||||||||:|||:||.||.||.|||||||||||||||||
  Fly   209 QGYACPQYHNSKDKRRSPRKYKYRSTPCPNVKHGEEWGEPGNCEAGDNCQYCHTRTEQQFHPEIY 273

Human   324 KSTKCNDMQQSGSCPRGPFCAFAHVEQPPLSDDLQPSSAVSSPTQPGPVLYMPSAAGDSVPVSPS 388
            |||||||:||:|.|||..||||||||  |.|.|                             ..:
  Fly   274 KSTKCNDVQQAGYCPRSVFCAFAHVE--PCSID-----------------------------EKT 307

Human   389 SPHAPDLSALLCRNSSLGSPSNLCGSPPGSIRKPPNLEGIVFPGESGLAPGSYKKAPGFEREDQV 453
            ..|...|:.|:         ||                  .:|        ..|....|:|.|.:
  Fly   308 RDHTVYLNELI---------SN------------------AYP--------DLKAQDAFQRVDNL 337

Human   454 GAEYLKNFKCQAKLKPHSLEPRSQEQPLLQPKQDMLGILPAGSPLTSSISSSITSSLAATPPSPV 518
                            .:::..|..:.|:...::           |::.|..::.|      .|:
  Fly   338 ----------------LNIDGNSTNKMLVDALEN-----------TTNFSKFLSFS------RPL 369

Human   519 GTSSVPGMNANALPFYPTSDTVESVIESALDDLDLNEFGVAALEKTFDNSTVPHPGSITIGGSLL 583
            .:.|...|:          |..|:.:.::|.:..|                            |.
  Fly   370 DSRSACSMD----------DPRENSLSASLANTSL----------------------------LT 396

Human   584 QSSAPVNIPGSLGSSA--SFHSASPSPPVSLSSHFLQQPQGH---LSQSENTFLGTSASHGSLGL 643
            :||||:|||.:..|::  .|:|.|.:..:. ||.....|..|   .:.....:.|::....||..
  Fly   397 RSSAPINIPNTTLSNSINDFNSGSFAVNIP-SSSLTYSPTNHANLFNVDAFNYGGSNKLSNSLSA 460

Human   644 NGMNSSIWEHFASGSFSPGTSPAFLSGPGA--AELARLRQELDEANSTIKQWEESWKQAKQACDA 706
            ...:||::  |.|...|||........|..  :||..:|.:::.::.....:|.:...||.|...
  Fly   461 TQNDSSLF--FPSRIISPGFGDGLSISPSVRISELNTIRDDINSSSVGNSLFENTLNTAKNAFSL 523

Human   707 WKKEAEEAGE--------------------RASAAGAECELAREQRDALEVQVKKLQEELERLHA 751
            ...:::...:                    |......:.::|...||..:   ::.||..||...
  Fly   524 QSLQSQNNSDLGRITNELLTKNAQIHKLNGRFEDMACKLKIAELHRDKAK---QEAQEWKERYDL 585

Human   752 GPEPQALPAFSDLEALSLSTLYSLQKQLRAHLEQVDKAVFHMQSVKCLKCQEQKRAVL--PCQHA 814
            ......|||  :|..||:..|..||.:||..||:|||.::...:.||:||:|..|.|.  ||.|.
  Fly   586 AQIQLNLPA--ELRDLSIQKLKQLQSKLRTDLEEVDKVLYLENAKKCMKCEENNRTVTLEPCNHL 648

Human   815 ALCELCAEG-SECPICQ 830
            ::|..|||. :|||.||
  Fly   649 SICNTCAESVTECPYCQ 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UNK	XP_016880736.1	CTH1	<153..347	CDD:227395	134/194 (69%)
		zf-CCCH	323..349	CDD:279036	20/25 (80%)
		ATP-synt_B	659..>757	CDD:304375	19/119 (16%)
		zf-C3HC4_3	794..830	CDD:290631	17/38 (45%)
unk	NP_001303430.1	zf-CCCH	273..299	CDD:279036	20/25 (80%)
		FhaB	<311..548	CDD:225751	55/345 (16%)
		zf-C3HC4_3	626..671	CDD:290631	19/40 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142987
Domainoid	1	1.000	357	1.000	Domainoid score	I984
eggNOG	1	0.900	-	-		E1_KOG1100
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I1018
Isobase	1	0.950	-	0	Normalized mean entropy	S4293
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D316647at33208
OrthoFinder	1	1.000	-	-		FOG0003517
OrthoInspector	1	1.000	-	-		oto89017
orthoMCL	1	0.900	-	-		OOG6_105234
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7783
SonicParanoid	1	1.000	-	-		X1211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.680