Protein Alignment ZFHX2 and zfh2

DIOPT Version :10

• Sequence 1: XP_016877205.1
• Gene: ZFHX2 / 85446
• HGNCID: 20152
• Length: 2576
• Species: Homo sapiens
• Sequence 2: NP_524623.2
• Gene: zfh2 / 43795
• FlyBaseID: FBgn0004607
• Length: 3005
• Species: Drosophila melanogaster
• Alignment Length: 3020
• Identity: 643/3020 - (21%)
• Similarity: 969/3020 - (32%)
• Gaps: 1123/3020 - (37%)

Human     6 SASTTGT----TPSPGHNA--PSLPSDTFSSSTPSDPVTKDPPAASSTSENMRSSEPGGQLLESG 64
            ||.|..|    |.:.|.:|  ||.|...|.:.:..:|            ||.:.:|....|
  Fly   199 SADTNDTEKLQTATEGSDATLPSSPQPVFRNVSELEP------------ENKQETEQNRLL---- 247

Human    65 CGLVPPKEIGEPQEGPDCGHFPPNDPGVEKDKEQEEEEEGLPPMDLSNHLFFTAGGEAYLVAKLS 129
                                        .:|:|||      |..|........|...||:  .||
  Fly   248 ----------------------------NQDREQE------PESDQHTSSSKMAAPSAYI--PLS 276

Human   130 LPGGSELLLPKGFPWGEAGIKEE--PSLPFLAYPPPSHLTALHIQHGFDPIQGFSSSDQILSHDT 192
            .|..:..|..|......|..|..  ..:...:.||.::.:...:....|.|....|:.  .:.:|
  Fly   277 SPKVAGKLTVKFGSLNSATAKTNNLSKVSSTSSPPSTYASGEVLSPSTDNISNHKSTH--CNQET 339

Human   193 SAPSPAA--CEERHGAFWSYQLAPNPPGDPKDGPMGNSGGNHVAVFWLCLLCRLGFSKPQAFMDH 255
            ..||.::  .|.:.|:     ::.:|..:..|.|..                  ||.:    |.|
  Fly   340 EPPSSSSSEVEMKIGS-----MSTSPQTNDSDVPCS------------------GFLQ----MQH 377

Human   256 TQSHGVKLTPAQYQGLSGSPAVL---QEGDEGCKALISFLEPKLPARPSSDIPLDNSSTVNMEAN 317
            ..:.|. .|| |......|.|.|   :..|...|.:..||:.:|....||..|
  Fly   378 MTTGGA-YTP-QVSSFHASLAALAANESNDNRVKLITEFLQQQLQQHQSSLFP------------ 428

Human   318 VAQTEDGPP--EAEVQALILLDEEVMALSPPSPPTATWDPSPTQAKES-PVAAGEAGPDWFPEGQ 379
             :...|.|.  ..:.:...|||.:..:.||.|        |..|..:| |....::.|...|...
  Fly   429 -SPCPDHPDLNGVDCKTCELLDIQQRSKSPSS--------SHHQFSQSLPQLQIQSQPQQTPHRS 484

Human   380 EEDGGLCPPLNQSSPTSKEGGTLPAPVGS------PEDPSDPPQPYRLADDYTPAPAAFQGLSLS 438
            .....:..|::.|:.:....|.......|      .|..:..||    ..|............|:
  Fly   485 PCSNSVALPVSPSASSVASVGNASTATSSFTIGACSEHINGRPQ----GVDCARCEMLLNSARLN 545

Human   439 SHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNC 503
            |.:. :.:||||||||||:||||||||:||::|||||||:..|.|.||.||..||||||||||:|
  Fly   546 SGVQ-MSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSC 609

Human   504 GYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQ------------------------------- 537
            |||||||::|||||||||||||||||||||.|:|
  Fly   610 GYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLSSSSPQVT 674

Human   538 -------GFQAGPG------------GQGSP-------PEASLPPSAGDKEPKTKSSWQCKVCSY 576
                   |..||.|            |..:|       ..|:...:..:...|.|.|::|.:|||
  Fly   675 AACPSNSGSGAGSGSSNIVGGTASLSGNATPSVTGANSSNANAGSNTNNAGTKPKPSFRCDICSY 739

Human   577 ETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMGPGPPPPPGATPTSPPELFQYFGPQALG 641
            :|:::||||||||||||..|:.:|...:                      ...:.|.:...|...
  Fly   740 DTSVARNLRIHMTSEKHTHNMAVLQNNI----------------------KHIQAFNFLQQQQQS 782

Human   642 -------------QPQTPLAGPGLRPDKPLEAQLL-LNGFHHVGAPARKFPTSAPGSLSPDAHLP 692
                         .|:..||  .|..::.|..||| ....|...|..:..|:|:|.|........
  Fly   783 GTGNIASHSSGSFMPEVALA--DLAYNQALMIQLLHQQQQHQQSANTKLSPSSSPVSTPDQFSFS 845

Human   693 PSQL-----------------LGSS-----SDSLPTSPPP---DDSLSLKVFRCLVCQAFSTDSL 732
            |..:                 :|.|     |..|...|.|   .|...:..:.||||..:||::|
  Fly   846 PKPIKLNHGTGAAMGIGMAMGMGMSHSNEVSCELSGDPHPLTKTDKWPMAFYSCLVCDCYSTNNL 910

Human   733 ELLLYHCSIGR----SLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHAQKYQLAAHLR 793
            :.|..|..:.|    |...:|...:..:.:.|:||.|.|.||||||||.|||||.||.....|:|
  Fly   911 DDLNQHLLLDRSRQSSSASSEIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIR 975

Human   794 EGGGAMGTPSPASLGDGAPYG-----------SVSPLHLRCNICDFESNSKEKMQLHARGAAHEE 847
            |||               |..           :.:.:.|:||.|||.:||.:|:.||.:...|:.
  Fly   976 EGG---------------PQNEYKMQYQQQQLAANVVQLKCNCCDFHTNSIQKLSLHTQQMRHDT 1025

Human   848 NSQIYKFLL------DMEGAEAGA--------------ELGLYH------CLLCAWETPSRLAVL 886
            ...|::.||      :|....:|:              :|.|..      |.||.:...:...::
  Fly  1026 MRMIFQHLLYIVQQSEMHNKSSGSAEDDPQCACPDEDQQLQLQSSKKLLLCQLCNFTAQNIHEMV 1090

Human   887 QHLRTPAHRDAQ----AQRR------------------------------LQLLQ---NGPTTEE 914
            ||::...|...:    .|||                              |.|.:   |..||:.
  Fly  1091 QHVKGIRHLQVEQFICLQRRSENQEIPALNEVFKVTEWVMENEDVSLAPGLNLARTTTNDATTDA 1155

Human   915 GLAALQS--------ILSFSH--------------GQLRTP-----GKAPVTPLAEPPTPEKDAQ 952
            ..||..|        :..||.              .|:..|     |....|.:.:....|...|
  Fly  1156 SYAAASSAAVPAIPDVSMFSPTSPSSCATSCDKNLSQIVLPNVNNLGSGVPTTVFKCNLCEYFVQ 1220

Human   953 NKTEQLASEETENKTGPSRD-----------SANQTTVRIGVYCCPY--CSFLSPESSQ------ 998
            :|:|..|..|||:....|.:           .|.||.|........:  |:.::|.:..
  Fly  1221 SKSEIAAHIETEHSCAESDEFITIPTNTAALQAFQTAVAAAALAAVHQRCAVINPPTQDTVDEDK 1285

Human   999 ------------VRAHTLSQHA----------------------VQPK-------YRCPLCQEQL 1022
                        ::...|.|..                      ..||       .:||||.|.
  Fly  1286 DLDTNVSDGPVGIKQERLEQEVDRTTSMDVTKDLASQATDFGAPESPKVAETEVGVQCPLCLEN- 1349

Human  1023 VGRPALHF--------HLSHLHNVVPECVEKLLLVATTVEMTFTTKVLSAPTLSPLDNGQEPPTH 1079
                  ||        ||:.:|:|..:.:.:|||:.....:...:..::.||
  Fly  1350 ------HFREKQYLEDHLTSVHSVTRDGLSRLLLLVDQKALKKESTDIACPT------------- 1395

Human  1080 GPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPGQPPSPAPSPVPEPDAQAEDV 1144
                    |:|........|.:|.|:..  ..:|.:....|.:|.|..|.......:.:|..:.
  Fly  1396 --------DKAPYANTNALERAPTPIEN--TCNVSLIKSTSANPSQSVSLQGLSCQQCEASFKH- 1449

Human  1145 APPPTMAEEEEGTTGELRSAEPAPADSRH---P--LTYRKTTNFALDKFLD----------PARP 1194
             ....:...::.....|::.|.....:.|   |  :|:| |....:..|.|          ....
  Fly  1450 -EEQLLKHAQQNQHFSLQNGEYLCLAASHISRPCFMTFR-TIPTMISHFQDLHMSLIISERHVYK 1512

Human  1195 YKCTVCKESFTQKNILLVH--YNSVSHLHKMKKAAIDPSAPARGEAGAPPTTTAATDKPFKCTVC 1257
            |:|..|..:|..:..|..|  |      |.|:.|.                         ||:.|
  Fly  1513 YRCKQCSLAFKTQEKLTTHMLY------HSMRDAT-------------------------KCSFC 1546

Human  1258 RVSYNQSSTLEIHMRSVLHQTRSRGTKTDSKIEGPERSQEEPKE---GETEGEVGTEKKGPDTSG 1319
            :.::..:..|:.||.....:..:..|:|:|. :.|..|.||..:   .|:.. |..|..|.|.|
  Fly  1547 QRNFRSTQALQKHMEQAHAEDGTPSTRTNSP-QTPMLSTEETHKHLLAESHA-VEREVSGSDVS- 1608

Human  1320 FISGLPF------------LSPPPPPLD-------LHRFPAPL-----------FTPPVL----- 1349
                 |.            |||.|..||       |..|.|.|           ..|..|
  Fly  1609 -----PIELETHLNKETRHLSPTPMSLDSQSHQKHLATFAALLKQQQCNSDAGGLHPEALSMSTG 1668

Human  1350 --PP-----------------------FPLVPESLLKLQQQQLLLPFYLHDLKVGPKL------- 1382
              ||                       .|:.|..:|.:.|...|:.  |:.:.:.|.|
  Fly  1669 EMPPQLQGLQNLQHIQQHFGAVAAAAGLPINPVDMLNIMQFHHLMS--LNFMNLAPPLVFGANAA 1731

Human  1383 --TLAGPA-----------------------------PVLSLPAATPPPPPQ------------- 1403
              .::||:                             ||.|..|...||..|
  Fly  1732 GNAVSGPSALNNSITTSTATSASGLGDTHLTSGVSSIPVDSGKATAVPPQTQLNANANSQQLASN 1796

Human  1404 -------------------------PPKAELAE------------REWERPPMAKE--GNEAGP- 1428
                                     |.:..:.|            :.|.|..:.||  .|:..|
  Fly  1797 QKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKVVKHWFRNTLFKERQRNKDSPY 1861

Human  1429 --SSPPD-----------------PLPNEAARTAAKALLENFGFELVIQYN-------------- 1460
              ::||.                 || |:....|....:.:....|....|
  Fly  1862 NFNNPPSTTLNLEEYERTGQAKVTPL-NDTCSVAVTGPMTSSTISLPPSGNINLSSKENATSKVL 1925

Human  1461 -EGK---------QAVPPPPTP-PPPEALGG--------GDKLACGACG---------------- 1490
             .||         .|..|..|| ..||:...        |:.:..|..|
  Fly  1926 AAGKANASGPVTFSATVPVSTPLSRPESTNSSGNISDYIGNNIFFGQLGSKEQILPYSLDGQIKS 1990

Human  1491 ----------------KLFSNMLILKTHEEHVHRRFLPFEALSRYAAQF---------------- 1523
                            |..|:...||..::.|..   |.:.|:...|..
  Fly  1991 EPQDDMIGATDFAYQTKQHSSFSFLKQQQDLVDP---PEQCLTNQNADTAQDQSLLAGSSLASNC 2052

Human  1524 ----------RKSYDSLYPPLAEPPKPPDGS---------------LDSPVPHLGPP-------- 1555
                      .||.......|:.||.|..|:               |::...::|||
  Fly  2053 QSQQQINIFETKSESGSSDVLSRPPSPNSGAAGNVYGSMNDLLNQQLENMGSNMGPPKKMQIVGK 2117

Human  1556 ----FLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVPAGRRFSRTKFTEFQTQALQS 1616
                .:.|...:|....           ..|...|:..:.......|:|.:||:||::|.:.||.
  Fly  2118 TFEKNVAPMVTSGSVST-----------QFESNSSNSSSSSSSTSGGKRANRTRFTDYQIKVLQE 2171

Human  1617 FFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARK-------NACEGGSMPTGGGTGGAS 1674
            |||.::||||.::|.|:.||.|:.||:||||||||||.||       |...............|
  Fly  2172 FFENNSYPKDSDLEYLSKLLLLSPRVIVVWFQNARQKQRKIYENQPNNTLFENEETKKQNINYA- 2235

Human  1675 GCRRCHATFSCVFELVRHLKK-CYDDQTLEEEEEEAERGEEEEEVEEEEVEEEQ---------GL 1729
             |::|:..|...:||:||.|. |:.:   |..::.|:......::.:....|:.         |:
  Fly  2236 -CKKCNLVFQRYYELIRHQKNHCFKE---ENNKKSAKAQIAAAQIAQNLSSEDSNSSMDIHHVGI 2296

Human  1730 EPPA-----------GPEGPLPEP---------PDGEELSQAEATKAGGKEPEEKATPSP----- 1769
            .||.           |...|||..         |..:.|. |:::......|  ..||:|
  Fly  2297 CPPGSAVASHTLSTPGSAAPLPGQYTQHSFGALPSPQHLF-AKSSSLTDFSP--STTPTPPQRER 2358

Human  1770 ---------SPAHTCDQCAISFSSQDLLTSHRRLH--------------------------FLPS 1799
                     .|...||:|.::|:..:.|..|:.||                          .|.|
  Fly  2359 SNSLDQIQRPPKFDCDKCELNFNQLEKLREHQLLHLMNPGNICSDVGQNSNPEANFGPFGSILQS 2423

Human  1800 LQPSAPPQLLDLPLLVFGERNPLVAATSPMPGPPLKRKHEDGSLSPTGSEAGGGGEGEPPRDKRL 1864
            ||.:|..|...      ..:.|          |..|||:.|  .|....|.....|.|..:.|.
  Fly  2424 LQQAAAQQQQQ------HHQQP----------PTKKRKYSD--CSSNADEMQSLSELEASQKKH- 2469

Human  1865 RTTILPEQLEILYRWYMQD------------SNPTRKM---------LDCIS------------- 1895
                     |.||:::||:            ....:|:         ||.::
  Fly  2470 ---------EYLYKYFMQNETSQEVKQQFLMQQQQKKLEQGNECDFELDFLTNFYQQNELKKVSN 2525

Human  1896 -----------EEV---------GLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATAT 1940
                       ||.         ..||..::...|..:..|.|..|:.    |.||.:.|.....
  Fly  2526 YDFLLQYYRTHEEAKSSQQHTFSSSKKPTIEFLLQYYQLNESKKFFQL----VASPQIIPDVPGY 2586

Human  1941 PASLPKFNLLLGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLP- 2004
            ..||        ::...|..|||.....:....|..........|    ....|:.|..|.:..
  Fly  2587 KPSL--------RIPKSTSDEAPYIGETSLEQATELQREKQDEQL----RIDRPSEENDLSMNKN 2639

Human  2005 ------------------------PPPPSEEEGPEEPPKASPESE---ACS-------------- 2028
                                    |...::||..:|....:.:.|   .|:
  Fly  2640 KVENINNNNINVDQSNLTETNGGVPSVETKEECTQESSLIAMDDENKYLCTRSKQKDDKEKSHYL 2704

Human  2029 ------LSAGDLSDSSAS-------------SLAEPESPGAGGTSGGPGGGTGVPDGMGQRRYRT 2074
                  |.|..:.::|.:             .|.:..:.....:|..|...:...:    :|.||
  Fly  2705 HNLEDFLDATMIENNSQTLTFNDDEKACQKDELTQNSNAIEKRSSVSPVNVSSKQN----KRLRT 2765

Human  2075 QMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAA----- 2134
            .:...||..:..||::...|:.:..|.:.:::.|.|||:||||||:|||:||::.|...|
  Fly  2766 TILPEQLNFLYECYQSESNPSRKMLEEISKKVNLKKRVVQVWFQNSRAKDKKSRNQRHYAHISDD 2830

Human  2135 ----GSTGGS------SEGL-----LAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVR- 2183
                ||:|..      |.|:     |.....||..|.|.   .|:.|.|.||.:|::|:|:.:.
  Fly  2831 NSYDGSSGKEVYSDLRSNGITVDTDLETNLQDCQLCQVT---QVNIRKHAFSVEHISKMKKLLEQ 2892

Human  2184 -----AQLKS----------ESKCYDLAPA 2198
                 ||...          |.:.|:|:.|
  Fly  2893 TTELYAQSNGSGSEDNDSDREKRFYNLSKA 2922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZFHX2	XP_016877205.1	PHA03247	<2211..2369	CDD:223021
		C2H2 Zn finger	2457..2500	CDD:275371
		C2H2 Zn finger	2501..2523	CDD:275371
		C2H2 Zn finger	455..475	CDD:275368	15/19 (79%)
		zf-H2C2_5	508..532	CDD:404746	21/23 (91%)
		C2H2 Zn finger	510..527	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1197..1219	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1254..1272	CDD:275368	4/17 (24%)
		Homeodomain	1599..1656	CDD:459649	32/56 (57%)
		Homeodomain	1862..1918	CDD:459649	15/109 (14%)
		Homeodomain	2070..2126	CDD:459649	22/55 (40%)
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	15/19 (79%)
		C2H2 Zn finger	616..633	CDD:275368	14/16 (88%)
		C2H2 Zn finger	1515..1542	CDD:275371	9/57 (16%)
		C2H2 Zn finger	1543..1564	CDD:275371	5/20 (25%)
		Homeodomain	1798..1857	CDD:459649	6/58 (10%)
		Homeodomain	2155..2211	CDD:459649	32/55 (58%)
		Homeodomain	2761..2817	CDD:459649	22/55 (40%)