DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HELZ2 and upf1

DIOPT Version :9

Sequence 1:	XP_024307774.1	Gene:	HELZ2 / 85441	HGNCID:	30021	Length:	2677	Species:	Homo sapiens
Sequence 2:	NP_593080.1	Gene:	upf1 / 2542327	PomBaseID:	SPAC16C9.06c	Length:	925	Species:	Schizosaccharomyces pombe

Alignment Length:	814	Identity:	212/814 - (26%)
Similarity:	330/814 - (40%)	Gaps:	205/814 - (25%)

- Green bases have known domain annotations that are detailed below.

Human  1889 TSLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFCALES 1953
            ||.|   :|...:||...|..:  ||.:::|.:..|   ..:...||:|...|..|..|....|
pombe   179 TSQQ---MVRLEELWRKDPNAN--LEDLDKPIEDDS---LPSVELRYKDAHAYQAVLSPLIQAE- 234

Human  1954 ATGAVAEND-----SVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADIN--FSCCYLCIR 2011
                 |:.|     |.|.:.:.|.|:.:                        ||  ::..:|..:
pombe   235 -----ADYDKRLKESQTQKDVVVRWDQA------------------------INKRYTAWFLLPK 270

Human  2012 LEGLPAPTASPRPGPSSLGPGLNVDPGTY------TWVAHGQTQDWDQERRADRQEAPRRVHLFV 2070
            ||......|        :|..:.:   ||      .|.:.|..           .:.|..|.
pombe   271 LESGEIRLA--------IGDEMKL---TYEGELRAPWSSTGYV-----------IKIPNNVS--- 310

Human  2071 HHMGME-----KVPEEVLRPGTLFTVELLPKQLPDLRKEEAVR-----GLEEASPLVTSIALGRP 2125
            ..:|:|     |||.|....   |:|:.:.|.....|.:.|:|     |...:|.|...: ||..
pombe   311 DEVGLELKRSDKVPIECTHN---FSVDYVWKSTSFDRMQTALRLFATDGSRLSSFLYHKL-LGHD 371

Human  2126 VPQPLCRGRSAPPLQLPLWPPAPPCMSAQGGCPLSVIPSRFLERQTYNIPGGRHKLNPSQNVAVR 2190
            :|....:.:....|.:|                              |:|    |||.||:.|||
pombe   372 IPPSFLKPKLPSDLSVP------------------------------NLP----KLNASQSEAVR 402

Human  2191 EALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVD 2255
            ..|.||.::||||||||||:....:|  :|.:..:         ..||.....:|.|.|||.:||
pombe   403 AVLSKPLSLIQGPPGTGKTVTSASVV--YHLATMQ---------SRKRKSHSPVLVCAPSNVAVD 456

Human  2256 VLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPN 2320
            .||. .:.|..|:.:||.::..|..|                      .|:..::||.:|:.  .
pombe   457 QLAE-KIHRTGLRVVRVAAKSREDIE----------------------SSVSFLSLHEQIKN--Y 496

Human  2321 PYSSEI-KAFDTRLQRGELFSREDLVWYKK--VLWEARKFELDR-HEVILCTCSCAASASLKILD 2381
            .::.|: :....|.:..||..:::    ||  :|..|.:.||.| ..||.|||..|....:....
pombe   497 KFNPELQRLLKLRSENNELSIQDE----KKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKYK 557

Human  2382 VRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFER---YH 2443
            .|.:|:|||..|:|||.:||||.  .|::|||:|||:||.|||.|:::....|.:|||||   ..
pombe   558 FRSVLIDEATQASEPECMIPLVL--GAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFERLIILG 620

Human  2444 EDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAG----KESCPVIFGHVQGHE 2504
            .....|..|||||..:..|||..||:..|:  .|:.....:..|..    :...|::|....|.|
pombe   621 NSPFRLVVQYRMHPCLSEFPSNTFYEGTLQ--NGVTTSERIARHVDFPWIQPDSPLMFYANFGQE 683

Human  2505 RSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREG-- 2567
            ......|...|....:..|::....       |...|.|:.|.::|||:.|.|.|.:.::..|
pombe   684 ELSASGTSFLNRTEASTCEKIVTTF-------LRSNVLPEQIGIVTPYDGQRSYIVQYMQNNGSM 741

Human  2568 ----IAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTR 2628
                ...|.|:|:...||.|..::::|.||:.....             :|||.||.::|||:||
pombe   742 QKDLYKAVEVASVDAFQGREKDFIILSCVRSSEHQG-------------IGFVNDPRRLNVALTR 793

Human  2629 AQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLV 2662
            |:.|:.::|:..:|....||...:..|:.:..||
pombe   794 AKYGVIVLGNPKVLAKHALWYHFVLHCKEKGYLV 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HELZ2	XP_024307774.1	ZnF_U1	39..69	CDD:197732
		AAA_11	541..705	CDD:331082
		UvrD_C_2	715..915	CDD:328976
		RNB	1334..1693	CDD:214935
		AAA_11	2180..2427	CDD:315699	86/250 (34%)
		AAA_12	2434..2639	CDD:315700	60/217 (28%)
upf1	NP_593080.1	UPF1_Zn_bind	44..193	CDD:286500	6/16 (38%)
		DNA2	66..839	CDD:224037	212/814 (26%)
		P-loop_NTPase	392..>597	CDD:304359	83/246 (34%)
		AAA_12	608..805	CDD:289832	60/218 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910