Protein Alignment KIN4 and par-1

DIOPT Version :10

• Sequence 1: NP_014876.1
• Gene: KIN4 / 854408
• SGDID: S000005759
• Length: 800
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 982
• Identity: 241/982 - (24%)
• Similarity: 388/982 - (39%)
• Gaps: 287/982 - (29%)

Yeast     8 HTYGGNVVTDRDRHSLQRNNEILHPIHKNQRKHAT----------------------FGPYIIGS 50
            ||.|..|....:::.|..::  .||....||..:.                      .|.|.:..
  Fly   195 HTPGSGVAPTVNKNVLSTHS--AHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIK 257

Yeast    51 TLGEGEFGKVKLGWTKASSSNEVP--KQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNII 113
            |:|:|.|.||||       :..:|  |:||||:|  |..:.:.....|::||:..:|.|.||||:
  Fly   258 TIGKGNFAKVKL-------AKHLPTGKEVAIKII--DKTQLNPGSLQKLFREVRIMKMLDHPNIV 313

Yeast   114 YLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKL 178
            .|.:|::..|.:.:::|:.||||.:.|:....|:||..|...|.|::|.|.|.|.|.::|||||.
  Fly   314 KLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKA 378

Yeast   179 ENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILY 243
            ||||||...|:.|.||||.|||...::| .|.||||.|||||| ...|.|:..:.||||.|||||
  Fly   379 ENLLLDSELNIKIADFGFSNEFTPGSKL-DTFCGSPPYAAPEL-FQGKKYDGPEVDVWSLGVILY 441

Yeast   244 AMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIK 308
            .:::|.||:|       |..:..|.:.:.:...:.|.|::....:|||:.||.||.:|.:|:||.
  Fly   442 TLVSGSLPFD-------GSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIM 499

Yeast   309 RHVW---------LKPH--------------------------EAFLSIQPNYWDEH-----LQK 333
            ...|         |||:                          ||.|| |..|.|..     |.:
  Fly   500 GDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLS-QVRYDDVFATYLLLGR 563

Yeast   334 ERPKPPNKG---------------DVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRMSPQLA- 382
            :...|.:.|               |.|.::. |:|..|.:......|:...||....|.|..:.
  Fly   564 KSTDPESDGSRSGSSLSLRNISGNDAGANAG-SASVQSPTHRGVHRSISASSTKPSRRASSGVGP 627

Yeast   383 TSRPASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNK 447
            |:..|:...:||:...:|.: |:...:....:|.|....:.|.:..:..| |::.:||.:::..:
  Fly   628 TNAAATVAAATGAVGAVNPS-NNYNAAGSAADRASVGSNFKRQNTIDSAT-IKENTARLAAQNQR 690

Yeast   448 HTSVAG--LVTI------PGSPTTARTRNAP-----------------SSKLTEHVKDSSQTSFT 487
            ..|...  |.|.      |..|.|| |:..|                 |:.|.|....:.:|:..
  Fly   691 PASATQKMLTTADTTLNSPAKPRTA-TKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVI 754

Yeast   488 QEE---FHRI-------GNYHVPRSRPRPTSYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDP 542
            ..|   |.|:       .:.|.||:.|..::::.|.:|  |.|:.|   :...|::|...|:..|
  Fly   755 PAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTR--ARNNTA---LEYSGTSGASGDSSHP 814

Yeast   543 VPLN-----AIHDTNKATISNNSIMLLSEGPAAK------------TSPVDYHYAIGDLNHGDKP 590
            ..::     :...:.:.||::.         |||            |||:.....:       :.
  Fly   815 GRMSFFSKLSSRFSKRPTIADE---------AAKPRVLRFTWSMKTTSPLMPDQIM-------QK 863

Yeast   591 ITEVIDKINKDLTHKAAENGFPRESI-------DPESTS----TILVTKEPTNSTDEDHVE---- 640
            |.||:|:.|.|...        ||..       ||.:.|    .|.|.|.|..|.:....:
  Fly   864 IREVLDQNNCDYEQ--------RERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISG 920

Yeast   641 --------------------SQLENVGHSSNKSDASSD--------------KDSKKIYEKKRFS 671
                                :|..|.|:::..:...:|              .||     ..|.|
  Fly   921 TSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDS-----TSRLS 980

Yeast   672 FMSL----YSSLNGSRSTVESRTSKGNAPPVSSRNP--------SGQSNRSNIKITQQQPRNLSD 724
            .:||    .:|..||:...:||.|.|.:......|.        |..|::.|::.:::
  Fly   981 ELSLLCRSLTSQQGSQRRKKSRLSTGGSEDQKKSNSLLSAFQMYSPFSSKENMQSSEE------- 1038

Yeast   725 RVPNPDKKINDNRIRDNAPSYAESENPGRSVRASVM-----VSTLREENRSELSNEGNNVEAQTS 784
                    :.|..:.|.        .||.||...:.     ::.:.||       :...||...:
  Fly  1039 --------VEDLHVIDT--------QPGHSVDVPLFADFSPINPIMEE-------DAEGVEGGKT 1080

Yeast   785 TARKVLN 791
            :..||::
  Fly  1081 SEAKVIS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	110/279 (39%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	108/269 (40%)
		UBA_MARK_Par1	525..563	CDD:270522	8/38 (21%)
		MARK1-3_C	839..936	CDD:213381	20/111 (18%)