DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5l and Cdc5

DIOPT Version :9

Sequence 1:	NP_445979.1	Gene:	Cdc5l / 85434	RGDID:	70892	Length:	802	Species:	Rattus norvegicus
Sequence 2:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	512/816 - (62%)
Similarity:	622/816 - (76%)	Gaps:	37/816 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65

  Rat    66 EEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDP 130
            ||:||||||||||||||||||||||||||||||.||:|||:..::::.|:|.|||||||||||||
  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDP 130

  Rat   131 NPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAG 195
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||
  Fly   131 NPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAAG 195

  Rat   196 IEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDR 260
            |. ...||:.:|:||||||||||:||.||||||||:.|..:.||.|:||||||||||||||.|:|
  Fly   196 IG-SGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMRQQDLDGELRSEKEERER 259

  Rat   261 KKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAE 325
            |:|||.||::||:::|:|:||.   .|..:||||||||.|||||.|||:|||:|:|||:|::.|.
  Fly   260 KRDKQKLKQRKENEVPTAMLQN---MEPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAG 321

  Rat   326 ESGITNSASSTLLSEYNVTNNSIALRTPRTPAS-QDRILQEAQNLMALTNVDTPLKGGLNTPLHE 389
            ||||  ..:..||::|::|....|  ||||||. .|||:|||||:||||:.:|||||||||||||
  Fly   322 ESGI--ETTDALLADYSITPQVAA--TPRTPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHE 382

  Rat   390 SDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPK-----PVTNA--------TPGR 441
            ||||||.|:...:.|||||::|||||...|. ..||....||.     ||..|        ||..
  Fly   383 SDFSGVLPKAASIATPNTVIATPFRTQREGG-AATPGGFQTPSSGALVPVKGAGGATGVVNTPAY 446

  Rat   442 TPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEERE 506
              :||||:||||:.|.....|::.|..:::.:..||.||..||||:||:|||:||..|.|..|..
  Fly   447 --VRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESERIETN 509

  Rat   507 MDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKS 571
            .:.. :||.||||||..|.::|.|.:|:::..:.:|:.||||:|||..||||.:.:..||:.|::
  Fly   510 SEPA-VEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQQA 573

  Rat   572 EELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHI-TYLEHSPYEKFSKEDLKKAQDV 635
            |||||.|||||..||.:..|..          |.:.:..|.: :|.:.:|||..|:::|.||:.:
  Fly   574 EELIKHEMITMQLYDSVKDPVP----------GQSQHKLEQLQSYFKANPYEDISQQELAKAKQM 628

  Rat   636 LVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINR 700
            |.:||||||:.|:||||..:.|.|||:||..||||||:|.|||||||||||||:||.|||||.||
  Fly   629 LTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRANLASKKDRLESAEKRLETNR 693

  Rat   701 GHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPR 765
            .||..||||..|:|||:|||.||||:||..|:|||.|.:.||||..:.|.||..|.:.|..|:||
  Fly   694 RHMAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFRFLGEQEAIAVPR 758

  Rat   766 RLECLKEDVQRQQEREKELQQRYADLLMEKETLQAK 801
            |||.|:|||:||.:|||||||:||.|:.|:::|.::
  Fly   759 RLESLQEDVRRQMDREKELQQKYASLVEERDSLYSQ 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5l	NP_445979.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..106	CDD:212557	46/49 (94%)
		SANT	60..106	CDD:197842	42/45 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..143		26/34 (76%)
		Nuclear localization signal. /evidence=ECO:0000255	165..271		80/105 (76%)
		Required for interaction with CTNNBL1. /evidence=ECO:0000250\|UniProtKB:Q99459	200..206		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..278		22/31 (71%)
		Interaction with PPP1R8. /evidence=ECO:0000250\|UniProtKB:Q99459	260..606		176/359 (49%)
		Myb_Cef	404..655	CDD:288664	111/264 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..460		25/64 (39%)
		Interaction with DAPK3. /evidence=ECO:0000269\|PubMed:11884640	501..659		65/158 (41%)
		Interaction with PLRG1. /evidence=ECO:0000250\|UniProtKB:Q99459	706..800		55/93 (59%)
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	47/47 (100%)
		Myb_DNA-bind_6	11..71	CDD:290632	58/59 (98%)
		SANT_CDC5_II	56..108	CDD:212557	47/51 (92%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..648	CDD:288664	111/264 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340728
Domainoid	1	1.000	459	1.000	Domainoid score	I463
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13291
Inparanoid	1	1.050	963	1.000	Inparanoid score	I311
OMA	1	1.010	-	-		QHG55711
OrthoDB	1	1.010	-	-		D195986at33208
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		oto95518
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770