DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UBP2 and faf

DIOPT Version :9

Sequence 1:	NP_014767.3	Gene:	UBP2 / 854291	SGDID:	S000005650	Length:	1272	Species:	Saccharomyces cerevisiae
Sequence 2:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster

Alignment Length:	1658	Identity:	298/1658 - (17%)
Similarity:	525/1658 - (31%)	Gaps:	663/1658 - (39%)

- Green bases have known domain annotations that are detailed below.

Yeast    28 DRNGSVIED-LPLYGTSINQQSTPGDVDD---GKHLLYPDIATNLPLKTS-----DRLLDDILCD 83
            |:||.:.:. |.|:.|..:.|..|.:|.|   |.|:...|.:.:......     |:.:|:
  Fly   577 DKNGVMAQKVLKLFWTLAHSQEVPPEVLDQALGAHVKILDYSCSQERDAQKTIWLDKCVDE---- 637

Yeast    84 TIFLNSTDPKVMQKGLQSRGILKESMLSYSTFRSSIRPNCLGSLTDQVVFQTKSEYDSI-----S 143
               |.|.|..|    |.:..::::....|.|..:..:.....:...||:.:.:::|..:     |
  Fly   638 ---LKSGDGWV----LPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNS 695

Yeast   144 CPKYNKIHVFQAVIFNPSLAEQQISTFDDIVKIPI-----YHLKVSVKVRQELERLK-------- 195
            ...|.: .|.|.|..:|.|         |..:|.|     :|    |::.:.||.||
  Fly   696 LTAYME-KVRQMVTDSPGL---------DATRILIDGRFPHH----VQIAERLEFLKFLLKDGQL 746

Yeast   196 -------KHVGVTQFHSL--DHLHEYDR--------------------VDLSTFDSS----DPNL 227
                   |.:    :|.|  :.:...||                    ::...|:::    ||:|
  Fly   747 WLCADQAKQI----WHCLAVNAVFPADREECFRWFGKLMGEEPDLDPGINKDFFENNILQLDPHL 807

Yeast   228 L-DYGI-----------------------YVSDDTN--------KLI----------LIEIFKP- 249
            | :.||                       |:.|:.:        ::|          .|::.|.
  Fly   808 LTESGIKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEV 872

Yeast   250 --------EFNSPEEHESFTADA---IKKRYNAMCV--KNESLDKSETPSQVD------------ 289
                    :.|..|.||.|..:.   ::..|..:.:  |.:..::.:.|.|.|
  Fly   873 STALGPRLQENIAEFHEMFIGECCSRLRTHYGNIVILGKTQLQEELDAPDQSDNTNDESKDSKMR 937

Yeast   290 -------CFYTLFKI-----------FKG-----PLTRKSKAE----------PTKTIDSGNLAL 321
                   |  .:.|:           |.|     ||:|.::.:          |.::||  ::.:
  Fly   938 FIEAEKMC--RILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSID--DMEI 998

Yeast   322 NTHLNPEWLTSKYGF--------QASSEIDEETNEIFTEYVPPDMV---DYVNDLETRKIRESFV 375
            .||.|......|...        .|:.::|     :|  |...:|:   |.:|.|....||:.
  Fly   999 VTHSNETMAAFKRNLLKRIKGTSTANIKVD-----LF--YANDEMIGVSDEINPLYQYTIRDK-- 1054

Yeast   376 RKCLQLIFWGQLSTSLLAP------NSPLKNTKSVKG--------MSSLQTSFSTLPWFHLLGES 426
               :.|       |:.|.|      :||..::.|..|        |..:: |.||||
  Fly  1055 ---MNL-------TAKLTPVGTGLASSPDSSSDSSTGSPPRPCPDMQRVE-SESTLP-------- 1100

Yeast   427 RARILLNSNEQ---------------THSPL-DAEPHFINLSVSHYYTDRDIIRNYESLSSLDPE 475
              .::::.|.|               .|..| |:....::|    ...||..||..:.:..:...
  Fly  1101 --GVIISQNYQYTEFFLKLYQLGSDLEHGRLRDSAKVLLHL----LPCDRQTIRQLKIMCKVPKA 1159

Yeast   476 NIGLYFDALT------------YIANRKGAYQLIAYCGKQ---------DIIGQEALENALLMFK 519
            .:.:   |:|            |...:.|......:|..:         .::...::.:.||:..
  Fly  1160 AVTV---AVTGDKIAKDEEEKLYPTEQAGIEDEEEHCTPEQMFLHPTPAQVLYNLSVLHGLLIPA 1221

Yeast   520 INPKECNISELNEATLLSIYKYETSNKSQVTSNHLTNLKNALRLLAKYTKS---------DKLKF 575
            ::|       |.|:.||....:..|..:......||. .|.|.....:||.         .||..
  Fly  1222 LDP-------LGESALLVQSAWMHSGCAHFVLELLTK-NNFLPSADMHTKRASFQCVLRLAKLFL 1278

Yeast   576 YVDHEPYRALSQAYDTLSIDESVDE------DIIKTAYSVKINDSPGLKLDCDRALYTIAISKRS 634
            |:...   .||:..|...|.: :|.      ||:|..:|...:.|.| .|....|...:.:::..
  Fly  1279 YIVGS---VLSRVGDEPMICD-LDNGSRSQVDILKQNFSTMPSSSQG-TLRAISAKLAVILAREM 1338

Yeast   635 LD----------LF-NFLTEECPQFSNYYGPEKLDYQEALKLLQVNENASDETILKIFKQKWFDE 688
            |.          || :.|...||..|......:|.:..:...||...|:|.:          |::
  Fly  1339 LSASPEGDRCRTLFSSTLQWSCPDISTIKAVVQLAWASSCGNLQALGNSSGD----------FED 1393

Yeast   689 NVYEPD--QFLILRAALTKISIERNSTLITNFLLTGTIDPNSLPPENWPTGINNI---------- 741
            .|..||  .|.:.:.||..::|        :|:|..:.:.......|||..|.:|
  Fly  1394 EVIVPDGQDFSMCKEALEVLTI--------SFILNPSANEALTSDPNWPKFITSIVLKNPLRHVR 1450

Yeast   742 ----------GNTC--------YLNSLLQYYFSIAPLRRYVLEYQKTVENFNDHLSNS---GHIR 785
                      ...|        |:.:||     :..|:..|.:|:.|...|...|..:   |.|.
  Fly  1451 QVASEQLFLASTYCAGDRRPFVYMVNLL-----VGALKTLVPQYESTCAEFFSVLCRTLSYGCIY 1510

Yeast   786 RIGGREISRGEVERSIQFIYQLRNLFYA----MVHTR--ERCVTPSKELAYLAFAPSNVEVEFEV 844
            . ...:||.|.:...|:::.::|...:|    .||..  |..:..:|||.:...|.|..::
  Fly  1511 N-WPLQISEGLLGDEIKWLQRIRENVHATGDTQVHEELLEGHLCLAKELMFFLGADSKAQL---- 1570

Yeast   845 EGNKVVDQTGVLSDSKKETTDDAF----------------------------------------- 868
              |:::.:   |.|....|....|
  Fly  1571 --NELIHE---LIDDFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVP 1630

Yeast   869 TTKIKDTSLIDLEMEDGLNGDVGTDANRK------------------KN---------------- 899
            ..|:...:|||....|       ||..|:                  ||
  Fly  1631 NMKLLTNTLIDFVCTD-------TDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYM 1688

Yeast   900 ---------ESNDAEVSENEDTTG------------LTSPTRVAKI----SSDQLENALEMGRQ- 938
                     .::.|..::.||.:|            |.|....|.:    ||..:|:.|...|:
  Fly  1689 VPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKN 1753

Yeast   939 ---------QDVTECIGNVLFQ--IESG--------SEPIRYDEDNEQYDLVKQLFYGTTKQSIV 984
                     |.:...:|:...|  :..|        .||:..   .||.|.|:  |:.:..:|:.
  Fly  1754 YHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNL---REQQDAVE--FFMSLLESLD 1813

Yeast   985 P----------LSAT-------NKV-------RTKVERFLSLLINIGDHPKDIYDAFDSYFKDEY 1025
            .          ::||       .|:       .:|.|.|....::|.:| ..:.::.:.|.|.|.
  Fly  1814 EGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNH-SSLTESLEQYVKGEL 1877

Yeast  1026 LTMEEYGD------------VIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYM 1078
            |   |..|            .::.|.|...|.:|.:|::|..||.||:...|..:...|..::.|
  Fly  1878 L---EGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDM 1939

Yeast  1079 DRYADTENPLLLAKKKETEEMKQKLKVMKNRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTP 1143
            :.|.                                   .|||.:          ||.:.:
  Fly  1940 EPYT-----------------------------------VSGLAK----------LEGEVV---- 1955

Yeast  1144 LKIEAANDVIKTLRNNVQNIDNELMKLYNDINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYG 1208
                   :|....:.||:...                            |.|..:.:|.|:||.|
  Fly  1956 -------EVGDNCQTNVETTK----------------------------YELTGIVVHSGQASGG 1985

Yeast  1209 HYWIYIKDRN-RNG--IWRKYNDETISEVQEEE 1238
            ||:.||..:| .||  .|.|::|..::|.:..|
  Fly  1986 HYFSYILSKNPANGKCQWYKFDDGEVTECKMHE 2018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UBP2	NP_014767.3	RPT	585..641	CDD:404348	16/72 (22%)
		RPT	658..719	CDD:404348	12/62 (19%)
		Peptidase_C19J	735..1256	CDD:239131	123/700 (18%)
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	81/446 (18%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	81/444 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810