Protein Alignment UBP2 and Usp8

DIOPT Version :10

• Sequence 1: NP_014767.3
• Gene: UBP2 / 854291
• SGDID: S000005650
• Length: 1272
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 928
• Identity: 165/928 - (17%)
• Similarity: 284/928 - (30%)
• Gaps: 366/928 - (39%)

Yeast   430 ILLNSNEQTHSPLDAEPHFINLSVSHYYTDRDIIRNYESLSSLDPENIGLYFDALTY---IANRK 491
            :|::.|.:     ||:| ..|.::|   |..||::|:      ||:        :||   |...:
  Fly   223 VLMDWNTK-----DAQP-ATNTAIS---TLLDILKNW------DPD--------VTYRAPIQIVE 264

Yeast   492 GAYQLI-----AYCGKQDIIGQEALENALLMFKINPKECNISELNEATLLSIY------------ 539
            |.|:..     .:|....:...:...|            :|..:::....||:
  Fly   265 GGYEYFIMMYPTHCTNPSVQAPQQNNN------------DIETIDDIEYPSIHDITMKEDISAKD 317

Yeast   540 -----KYETSNK---SQVTSNHLTNLKNALRLLAKYTKSDKLKFYVDHEPYRALSQAYDTLSIDE 596
                 .:..:||   ::|....::......:.:|:..: |:.:|         |.:|       |
  Fly   318 FRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMR-DQAEF---------LQRA-------E 365

Yeast   597 SVDEDIIKTA--YSVKINDSPGLKLDCDRALY--TIAISKRSLDLF---NFLTEECPQFSNYYGP 654
            ..||.:.|.:  :..:..:..||....|:.|:  .:.:..::.|..   |.|.||..:....:
  Fly   366 QNDEQLEKASKMWKRQAAEGDGLNATEDQELHFRILQLESKAQDYIVENNRLREELSRIQELH-- 428

Yeast   655 EKLDYQEALKLLQVNENASDETILKIFKQKWFDE----NVYEPDQFLILRAALTK---------- 705
             .:..|.:.|.::...|...    ||.:::..||    ...|.::.|.:.....|
  Fly   429 -NVTQQLSQKEVEATRNIES----KIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGP 488

Yeast   706 ISIERN--------STLITNFLLTGTIDPNSLP---------------PENWP------------ 735
            .|..||        .:|.:...|||..||...|               |.|..
  Fly   489 PSPGRNLEDVHVVSDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPV 553

Yeast   736 ---------TGINNIGNTCYLNSLLQYYFSIAPLRRYVLEYQKTVENFNDHLSNSGHIRRIGGRE 791
                     ||:.|:|||||:||:||...:...|..|.:.     :.:.:::|.|..
  Fly   554 IGQNVGRGLTGLKNLGNTCYMNSILQCLSNTPQLTEYCIS-----DKYKNYISRSNK-------- 605

Yeast   792 ISRGEV-ERSIQFIYQLRNLFYAMVHTRERCVTPSKELAYLAFAPSNVEVEFEVEGNKVVDQTGV 855
             :.|:| |.....|.:|.|..|       :||. |::|.|                  ||.|...
  Fly   606 -TNGQVIEEVAALIKELWNGQY-------KCVA-SRDLRY------------------VVGQYQK 643

Yeast   856 LSDSKKETTDDAFTTKIKDTSLIDLEMEDGLNGDVGTDANRKKNESNDAEVSENEDTTGLTSPTR 920
            :.....:.....|.|.:.          |.|:.|:.|
  Fly   644 IFRGVDQQDSHEFLTILM----------DWLHSDLQT---------------------------- 670

Yeast   921 VAKISSDQLENALEMGRQQDVTECIGNVLFQIESGSEPIRYDEDNEQYDLVKQLFYGTTKQSIVP 985
                        |.:.||:::.           |.||....:....:..::..||||..| |.|.
  Fly   671 ------------LHVPRQREMI-----------SASEKAWLEFTKAKESMILHLFYGQMK-STVK 711

Yeast   986 LSATNKVRTKVERF--LSLLINIGDHPKDIYDAFDSYFKDEYL------TMEEYGDVIRTVAVTT 1042
            ..|.:|.....|.|  |||.:....:...:....|.||..|.:      :.:...|.|:.:.::.
  Fly   712 CVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLDISK 776

Yeast  1043 FPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRYADTENPLLLAKKKETEEMKQKLKVMK 1107
            .|.:|.|.::|.|.|             |.....||.:......||        |.:.....:.:
  Fly   777 LPPVLVVHLKRFYAD-------------PSNSGSYMKKQNYLRFPL--------ENLDMNPYIAR 820

Yeast  1108 NRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTPLKIEAANDVIKTLRNNVQNIDNELMKLYN 1172
            ...|.:                            ||          ||
  Fly   821 AESRAV----------------------------TP----------KT----------------- 830

Yeast  1173 DINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYGHYWIYIKDRNRNGIWRKYNDETISEVQEE 1237
                                |.|::|..|.|....|||..:.|..| .|.|.|::|:.:|.:...
  Fly   831 --------------------YQLYAVSNHYGTMEGGHYTAFCKSAN-YGKWFKFDDQVVSALDSS 874

Yeast  1238 EVFNFNEGNTATPYFLVY 1255
            .|.      ::..|.|.|
  Fly   875 NVV------SSAAYILFY 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBP2	NP_014767.3	RPT	585..641	CDD:463882	12/62 (19%)
		RPT	658..719	CDD:463882	14/82 (17%)
		Peptidase_C19J	735..1256	CDD:239131	99/551 (18%)
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647
		RHOD	148..278	CDD:444705	18/77 (23%)
		Smc	<361..>511	CDD:440809	29/163 (18%)
		Peptidase_C19R	564..887	CDD:239139	98/528 (19%)