Protein Alignment UBP2 and Usp14

DIOPT Version :9

• Sequence 1: NP_014767.3
• Gene: UBP2 / 854291
• SGDID: S000005650
• Length: 1272
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_001260321.1
• Gene: Usp14 / 34387
• FlyBaseID: FBgn0032216
• Length: 475
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 123/652 - (18%)
• Similarity: 211/652 - (32%)
• Gaps: 260/652 - (39%)

Yeast   671 NASDETILKIFKQKWFDENVYEPD-QFLILRAALTK-----ISIERNSTLITNFLLTGTIDPNSL 729
            |..:|.||  ||.:.|.....:|| |.::.:..:.|     :.|:..:.:    ||.|:  ..|:
  Fly    21 NTDEEPIL--FKAQLFALTGVQPDRQKVMCKGGILKDDQWNLQIKDGAVV----LLLGS--KESV 77

Yeast   730 P-----PENW---------------PTGINNIGNTCYLNSLLQYYFSIAPLRRYVLEYQKTVENF 774
            |     |..:               |.|:.|:|||||:|:.:|...::..||..:..:
  Fly    78 PEVPATPVKFIEDMNEAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVPELRTALSTF------- 135

Yeast   775 NDHLSNSGHIRRIGGREISRGEVERSIQFIYQLRNLFYAMVHTRERCVTPSKELAYLAFAPSNVE 839
                ||.|
  Fly   136 ----SNDG--------------------------------------------------------- 139

Yeast   840 VEFEVEGNKVVDQTGVLSDSKKETTDDAFTTKIKDTSLIDLEMEDGLNGDVGTDANRKKNESNDA 904
                                 .:|...||:......|:. .:||.|
  Fly   140 ---------------------TDTMSTAFSISSAMKSIF-AQMEKG------------------- 163

Yeast   905 EVSENEDTTGLTSPTRVAKI-----SSDQLENALEMG--RQQDVTECIGNVLFQIESGSEPIRYD 962
                       |:.|.:..:     :|.|.....|.|  ||||..||...:|..::....|...:
  Fly   164 -----------TTVTPIVLLQALHRASPQFAQTGENGTYRQQDANECWAEILKMLQQKLRPKNQE 217

Yeast   963 EDN----EQYDLVKQLFYGTTKQSI-------VPLSATNKVRTKVERFLSLLINIGDHPKDIYDA 1016
            ..|    .....:.|.|.||.:..:       .|.:.|:      |.||.|...|....|.:...
  Fly   218 PSNTVQKRHSSFIDQFFGGTFEVKMSSEEDPDEPSTVTS------ENFLQLSCFISMDVKYMQSG 276

Yeast  1017 FDSYFKDEYL----TMEEYGDVIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIY 1077
            ..|..|::.:    |:......|||..|:..|..|.||..|..|..:..:..|.::.:.|.  |.
  Fly   277 LKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTVQFVRFQYKGKEGINAKVLKDIKFP--ID 339

Yeast  1078 MDRYADTENPLLLAKKKETEEMKQKLKVMKNRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKT 1142
            .|.:           :..|.|::.||..|:::.::|   :|             |.:|.|.:|:
  Fly   340 FDAF-----------ELCTPELQNKLCPMRSKFKDL---ED-------------KKMEVDVVKR- 376

Yeast  1143 PLKIEAANDVIKTLRNNVQNIDNELMKLYNDINSLEEKISHQ---FDDFKEYG------YSLFSV 1198
                                         |:.|..::.:.::   |||  :.|      |:|.:|
  Fly   377 -----------------------------NEPNEEKKDVKYEQFWFDD--DLGSNNSGYYTLQAV 410

Yeast  1199 FIHRG-EASYGHY--WIYIKDRNRNGIWRKYNDETISEVQEEEVFNFN-EGNTATPYFLVYVKQG 1259
            ..|:| .:|.|||  |:    |:...:|.|::|:.:|.|..:|:...: .|:....|.|:|..:.
  Fly   411 LTHKGRSSSSGHYVAWV----RSSGDVWFKFDDDEVSAVATDEILRLSGGGDWHCAYVLLYAPRR 471

Yeast  1260 QE 1261
            .|
  Fly   472 LE 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBP2	NP_014767.3	RPT	585..641	CDD:404348
		RPT	658..719	CDD:404348	12/53 (23%)
		Peptidase_C19J	735..1256	CDD:239131	103/555 (19%)
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	14/57 (25%)
		UBQ	5..73	CDD:294102	14/57 (25%)
		UCH	103..467	CDD:278850	103/554 (19%)
		Peptidase_C19A	105..467	CDD:239122	102/552 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910