Protein Alignment UBP2 and Usp2

DIOPT Version :10

• Sequence 1: NP_014767.3
• Gene: UBP2 / 854291
• SGDID: S000005650
• Length: 1272
• Species: Saccharomyces cerevisiae
• Sequence 2: NP_001285528.1
• Gene: Usp2 / 33132
• FlyBaseID: FBgn0031187
• Length: 950
• Species: Drosophila melanogaster
• Alignment Length: 807
• Identity: 135/807 - (16%)
• Similarity: 236/807 - (29%)
• Gaps: 358/807 - (44%)

Yeast   543 TSNKSQVTSNHLTNLKNALRLLAKYTKSDKLKFYVDHEPYRALSQAYDTLSIDESVDEDI----- 602
            :||..|..|:.|.|    :|:.|.|:.|      :....||. :...:::|...:|..::
  Fly   405 SSNLQQRYSSDLDN----IRVAAGYSSS------LTRAAYRT-TATMNSVSTPVAVTSELGGPIS 458

Yeast   603 ------------------IKTAYSVKINDSPGLKLDCDRALYTIAISKRSLDLFNFLTEECPQFS 649
                              ::.|:|   |..|   ::||..:.|   :|.|.|.....|......:
  Fly   459 GDGGETATAMGQPTSKVTVRGAHS---NRQP---IECDSVVLT---NKASKDATTAATPTVATAT 514

Yeast   650 NYYGPEKLDYQEALKLLQVNENASDETILKIFK-----------------------------QKW 685
            ..:.|................:|||.....:.:                             .::
  Fly   515 ATHTPATSSVSTVTVTAAAPNSASDSVSRSLARSPISSTLARSGTGSSSTARSVLPPMTPTSSRY 579

Yeast   686 FDENVYEPDQFLILRAALTKISIERNSTLITNFLLTGTIDPNSLPPENWP--TGINNIGNTCYLN 748
            :|.:.......:...:||...|::.||.       .|....:|...|...  .|:.||||||::|
  Fly   580 WDRDSGTSRSSIGTSSALNSSSLKHNSD-------DGYKTASSSRDEKSEGLCGLRNIGNTCFMN 637

Yeast   749 SLLQYYFSIAPLRRYVLEYQKTVENFNDHLSNSGHIRRIGGREISRGEVERSIQFIYQLRNLFYA 813
            |::|.......|.|::               .|.|    |.|.:|..:.:...:|...::.::.|
  Fly   638 SVIQCLSHTQELTRFL---------------RSHH----GSRSLSTKDQQILHEFAKLIQEMWTA 683

Yeast   814 MVHTRERCVTPSKELAYLAFAPSNVEVEFEVEGNKVVDQTGVLSDSKKETTDDAFTTKIKDTSLI 878
            .|||    |||             :|::                        .||:||
  Fly   684 NVHT----VTP-------------MELK------------------------RAFSTK------- 700

Yeast   879 DLEMEDGLNGDVGTDANRKKNESNDAEVSENEDTTGLTSPTRVAKISSDQLENALEMGRQQDVTE 943
                            :|..::.|..:..|            ..:...|.|.:||..|.:.:...
  Fly   701 ----------------HRMYSDYNQQDAQE------------FLRFFLDSLHSALNSGVKGETLN 737

Yeast   944 CIGNVLFQIESGSEPIRYDEDNEQYD------------LVKQLFYGTTKQSI------------- 983
            ...|:              .||::.|            ||:.||.|..|.::
  Fly   738 IDDNL--------------SDNKKADLTWEWYTRHENSLVRDLFVGQLKSTLKCTTCGNTSVTFD 788

Yeast   984 ------VPLSATNKVRTKVERFLSLLINIGDHPKDIYDAFDSYFKDEYLTMEEYGDVIRTVAVTT 1042
                  |||.:::  |.|:|..|.|.|                 ::|.|..:|
  Fly   789 PFWDLSVPLPSSS--RCKLEACLDLFI-----------------REEVLDGDE------------ 822

Yeast  1043 FPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRYADTENPLLLAKKKETEEMKQKLKVMK 1107
            .||..:.:.:|      :.....:|:..|...||::.|:::|.              ..||.
  Fly   823 MPTCAKCKTRR------KCTKSFTIQRFPKYLVIHLKRFSETR--------------WSKLS--- 864

Yeast  1108 NRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTPLKIEAANDVIKTLRNNVQNIDNELMKLYN 1172
                                    .::|..|                        .|:||
  Fly   865 ------------------------NIVEFPT------------------------SDSEL----- 876

Yeast  1173 DINSLEEKISHQFDDFKEYG--------YSLFSVFIHRGEASYGHYWIYIKDR-NRNGIWRKYND 1228
                          :...||        |||:::..|.|..:.|||....|.. :|.  |.::||
  Fly   877 --------------NMGSYGANSNSNVHYSLYAISNHMGSTAGGHYVALCKHPVSRK--WHEFND 925

Yeast  1229 ETISEVQEEEVFNFNEGNTATPYFLVY 1255
            ..:|:...|     |...:::.|.|.|
  Fly   926 NIVSDALSE-----NHLVSSSAYILFY 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBP2	NP_014767.3	RPT	585..641	CDD:463882	12/78 (15%)
		RPT	658..719	CDD:463882	9/89 (10%)
		Peptidase_C19J	735..1256	CDD:239131	97/563 (17%)
Usp2	NP_001285528.1	UBP12	<620..>800	CDD:227847	51/288 (18%)
		Peptidase_C19R	626..948	CDD:239139	97/559 (17%)