DRSC/TRiP Functional Genomics Resources

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Protein Alignment APOL1 and apol1

DIOPT Version :10

Sequence 1:NP_663318.1 Gene:APOL1 / 8542 HGNCID:618 Length:414 Species:Homo sapiens
Sequence 2:XP_005171358.1 Gene:apol1 / 560340 ZFINID:ZDB-GENE-030131-3217 Length:465 Species:Danio rerio


Alignment Length:399 Identity:97/399 - (24%)
Similarity:175/399 - (43%) Gaps:94/399 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    52 QNVPSGT---DTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGF 113
            ||:.:|:   :|.| ..|.|.:|            ::|......::...::|..|:   :.||..
Zfish   121 QNIGAGSVVAETKD-HKKTLMEW------------LDDFRLSETQREDEEDLEGLM---DWWNTV 169

Human   114 VAAAELPRNE---ADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLR 175
            ....::|:|:   ..|..||....|           ||.|:....|.|.|......|..::..|.
Zfish   170 EQWEDMPKNDNMTEKEEAKAFAVTA-----------DKVQKGIRVFNKLFSERAEGLWQHVIDLH 223

Human   176 ALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMEL----GITAAL 236
            |:|||:.:.:|.|.||.:..||.|...|:.|:.|:.|||||.|.||::...|:.:    |:|:|.
Zfish   224 AIADGLDRFNKKTKIAQITGGSTSAVGGVATITGLILAPFTMGTSLIVTAVGLGVAMAGGLTSAS 288

Human   237 TGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRA 301
            .||||:                 |..|||: |:|...:|:    :.:..|:..:..:.|.:.|..
Zfish   289 AGITST-----------------VNNSLDR-KKVERIVGD----YQAKMGDLNKCMKFIKQGITN 331

Human   302 LRRARANLQSVPH----------------ASASRPRVTEPISAESGEQVERVNEPSILEMSRGVK 350
            ||:...| :...|                |.|.:..:|      :..::.||.:.:.:..:...:
Zfish   332 LRKFNLN-KMKKHAYNRDFPCFDNVYEDGAMAGKAILT------NANEIMRVMQIANVAGTTAAR 389

Human   351 LTDVAPVS------FFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEE---KLNILNNNYK 406
            ...:|.:|      .|:.:|:.::..:|..|..|||||.|.::::||::|.|   :|||:.:..:
Zfish   390 AVQIASISTGVLTGLFVGMDIYFVAKDSHELKNGAKSEFAAKIREVAEQLHEGLMELNIIRDELR 454

Human   407 I---LQADQ 412
            :   ::.||
Zfish   455 MTTTVKEDQ 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APOL1NP_663318.1 ApoL 104..403 CDD:461657 84/330 (25%)
apol1XP_005171358.1 ApoL 153..447 CDD:461657 83/336 (25%)

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