DRSC/TRiP Functional Genomics Resources

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Protein Alignment APOL1 and niki

DIOPT Version :10

Sequence 1:NP_663318.1 Gene:APOL1 / 8542 HGNCID:618 Length:414 Species:Homo sapiens
Sequence 2:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster


Alignment Length:422 Identity:82/422 - (19%)
Similarity:144/422 - (34%) Gaps:95/422 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    54 VPSGTDTGDPQSK---------PLGDWAAGTMDPESSIFIEDAIKYFKEKVST--QNLLLLLTDN 107
            :|.|.:|...||.         .:.|...|.    :|..:.:|:...|.::..  ::||.|....
  Fly    31 LPLGQNTQRKQSTCTRVLPTVFTITDGTTGA----ASTSLAEAMSSSKAQMPNRQESLLQLSVPR 91

Human   108 EAWNGFVAAAELPRNE------------ADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKE- 159
            |...| ||..||...|            |...|:..|  ..|::.|..|..:.....|:..:.| 
  Fly    92 ETGVG-VAGPELANYEKVRVVGQGSFGIAILYRRKSD--GHQIVFKQINLSELSPPGRDLAMNEV 153

Human   160 -------FPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVS---GSL------------SISS 202
                   .|.:.|.|...|:....|.:  .:...|.|:|.:::   |.|            .|||
  Fly   154 DVFSKLHHPNIVSYLGSFIKDNTLLIE--MEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISS 216

Human   203 GI-----------------LTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKW 250
            .|                 :.|...|:....:.|...::...:............|..|..||::
  Fly   217 AINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEY 281

Human   251 WTQAQ--AHDLVIKSLDKLKEVREFLGENISNFLS--LAGNTYQLTRGIGKDIRALRRARANLQS 311
            ..::.  |...::..:..||  :.|...|:|..::  :|||...:..|....:|:|......:::
  Fly   282 DNKSDIWALGCILGEMCCLK--KTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEA 344

Human   312 VPHASASR------PRVTEPISAESGEQVE-RVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLV 369
            ....:||.      |.:...:....|...| .|..|...:::..|.....:.||..|.|..... 
  Fly   345 PRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQT- 408

Human   370 YESKHLHEGAKSETAEELKKVAQELEEKLNIL 401
             |:|.|   ..::||     ...|:.||.::|
  Fly   409 -ETKQL---MIADTA-----APHEILEKRSVL 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APOL1NP_663318.1 ApoL 104..403 CDD:461657 69/361 (19%)
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855 44/260 (17%)
ATS1 433..749 CDD:444065
Blue background indicates that the domain is not in the aligned region.

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