Protein Alignment APOL1 and Apol2

DIOPT Version :10

• Sequence 1: NP_663318.1
• Gene: APOL1 / 8542
• HGNCID: 618
• Length: 414
• Species: Homo sapiens
• Sequence 2: XP_006242004.3
• Gene: Apol2 / 315111
• RGDID: 1309591
• Length: 405
• Species: Rattus norvegicus
• Alignment Length: 356
• Identity: 144/356 - (40%)
• Similarity: 209/356 - (58%)
• Gaps: 18/356 - (5%)

Human    59 DTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNE 123
            ||.||..        |...|.|..|||:|.:|.:......:|.||||::.||..|||.|||.|.:
  Rat    58 DTMDPSD--------GEDSPASRTFIEEATEYLQHTSGRDDLKLLLTEDGAWEAFVAEAELSRAD 114

Human   124 ADELRKALDNLARQMIMKDKN--WHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHK 186
            ||.||.||:.|...|..:|:|  .||.....|  |:..||::|.|||.::|:||.|||.|.|||:
  Rat   115 ADTLRDALNALTANMAEEDQNRLQHDLQDVER--FIDVFPQVKLELERHVRKLRTLADKVDKVHR 177

Human   187 GTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWW 251
            ..||:.||:||.|..||:|||:|:.|.|.|.|.|||||..||.||..||:|.:::..:||..|..
  Rat   178 DCTISKVVAGSTSTVSGVLTLLGLALVPVTAGVSLVLLATGMGLGAAAAVTSVSTGIVDYTSKSS 242

Human   252 TQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHAS 316
            .|.:|..||..|:.|:|...|.:..:.....||:.:..::.|.|.:.:.|::..:||    |..:
  Rat   243 AQTEASHLVSTSMVKVKMAAEAVVYSGPQVFSLSESCCRVLRCIEQSVYAIKLTKAN----PALA 303

Human   317 ASRPRV--TEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGA 379
            ||..|:  ...|||:|.:.|::..:.:.|.|||..::..:|.....|:.||:.||.|||:|::||
  Rat   304 ASVKRLMTVGSISAQSDKHVKKAFKGTALAMSRRTRIMGIATAGVSLIGDVISLVKESKNLYKGA 368

Human   380 KSETAEELKKVAQELEEKLNILNNNYKILQA 410
            |:::||||::.|:||||||.:|...|..||:
  Rat   369 KAKSAEELRQQARELEEKLEVLVQIYDGLQS 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APOL1	NP_663318.1	ApoL	104..403	CDD:461657	126/302 (42%)
Apol2	XP_006242004.3	None