Protein Alignment APOL1 and Apol8

DIOPT Version :10

• Sequence 1: NP_663318.1
• Gene: APOL1 / 8542
• HGNCID: 618
• Length: 414
• Species: Homo sapiens
• Sequence 2: XP_006520997.3
• Gene: Apol8 / 239552
• MGIID: 2444921
• Length: 439
• Species: Mus musculus
• Alignment Length: 343
• Identity: 138/343 - (40%)
• Similarity: 203/343 - (59%)
• Gaps: 14/343 - (4%)

Human    75 TMDPE-------SSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALD 132
            ||||.       ...|||:|.:|.:.....::|.||||::.||..|||.|||.|.:||.||.||.
Mouse   100 TMDPSDCEDAPGDRTFIEEAAEYLQHTSGREDLRLLLTEDGAWEAFVAEAELSRADADTLRDALH 164

Human   133 NLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGS 197
            .|...:.::|:....:..|....|:..||::|.|||.:|.:||.|||.|.|||:..||:.:|:||
Mouse   165 ALTANLAVEDQERLQRDLQDMERFMDAFPQVKLELEGHIGKLRTLADKVDKVHRDCTISKLVAGS 229

Human   198 LSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIK 262
            .|..||||||:|:.|.|.|.|.|||||..||.||..||:|.::|..:||..:...:.:|..||..
Mouse   230 TSTVSGILTLLGLTLVPVTAGISLVLLATGMGLGAAAAVTSVSSGIVDYTSRSLAKTEASHLVST 294

Human   263 SLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPIS 327
            .:.|:|.|.:.:..:....|||:.|..::.|.|.:.|.|::..:||    |..:||....|   |
Mouse   295 GMAKVKMVADAVVHSGPQVLSLSENCCRVLRCIEQSIYAIKLTKAN----PALAASAMGST---S 352

Human   328 AESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQ 392
            |:||:.|::..:.:.|.:||..::..:|.....||.||:.||.:||:||:|.|:::||||::.|:
Mouse   353 AQSGKHVKKAFKGTALAISRRARIMGIATAGVSLVGDVISLVKQSKNLHKGTKAKSAEELRQQAR 417

Human   393 ELEEKLNILNNNYKILQA 410
            ||||||..|...|:.|||
Mouse   418 ELEEKLEALIQMYEGLQA 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APOL1	NP_663318.1	ApoL	104..403	CDD:461657	122/298 (41%)
Apol8	XP_006520997.3	ApoL	136..428	CDD:461657	122/298 (41%)