Protein Alignment APOL1 and F07F6.8

DIOPT Version :10

• Sequence 1: NP_663318.1
• Gene: APOL1 / 8542
• HGNCID: 618
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_001379858.1
• Gene: F07F6.8 / 173926
• WormBaseID: WBGene00017220
• Length: 318
• Species: Caenorhabditis elegans
• Alignment Length: 350
• Identity: 73/350 - (20%)
• Similarity: 131/350 - (37%)
• Gaps: 122/350 - (34%)

Human    73 AGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQ 137
            ||:...::.:.|.|         |.::||.                :||:.:.||.   :...|.
 Worm    10 AGSQSEDNGVPIYD---------SLESLLF----------------IPRSMSKELS---ETALRT 46

Human   138 MIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISS 202
            ..:.|| |.:..::.                  :|::..:|:.:....||..|:..|..::.|:|
 Worm    47 QFLLDK-WSNNRRKI------------------VRQMEGIAEKLDNWEKGCAISTAVGSTVGIAS 92

Human   203 GILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDL-------- 259
            ||..:.|:.|.|......|::   |...|::...||||       |.:.|:.|..::
 Worm    93 GIAVIGGLILMPPVAIAGLIV---GTASGVSNLATGIT-------KFFHTKGQHKEVAAMIAEDG 147

Human   260 -----VIKSLDKLKE-VREFLGE-----------NISNFLS--LAGNTYQLTRGIGKDIRALRRA 305
                 ::||.::|.| ||:.:.:           :|.|.|.  ..|:...:| |||        .
 Worm   148 VLFEELLKSREELMEAVRKIVEDEEFFKHFKNDGDIENKLKTVFGGSVTGIT-GIG--------T 203

Human   306 RANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVY 370
            |..:.|:...|:|                          :.:|| |..||.:.  :|||.|.|..
 Worm   204 RFAITSMGRLSSS--------------------------LVKGV-LHSVAVIG--IVLDSVTLAL 239

Human   371 ESKHLHEGAKSETAEELKKVAQELE 395
            .:|.|.||:.||....:.:.:.::|
 Worm   240 SAKTLGEGSVSELGSSILEASSKME 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APOL1	NP_663318.1	ApoL	104..403	CDD:461657	65/318 (20%)
F07F6.8	NP_001379858.1	ApoL	<61..251	CDD:461657	55/237 (23%)