DRSC/TRiP Functional Genomics Resources

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Protein Alignment APOL1 and apold1b

DIOPT Version :10

Sequence 1:NP_663318.1 Gene:APOL1 / 8542 HGNCID:618 Length:414 Species:Homo sapiens
Sequence 2:XP_001920639.5 Gene:apold1b / 100150119 ZFINID:ZDB-GENE-160728-30 Length:470 Species:Danio rerio


Alignment Length:405 Identity:101/405 - (24%)
Similarity:164/405 - (40%) Gaps:99/405 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    57 GTDTGDPQSKPLGD----WAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAA 117
            |.||.|...|.:.|    .::....|||...:.......:::...:.||......|.|:.:    
Zfish   105 GGDTTDEAHKSIQDEDTQISSDLQSPESDAGVCSEASPLEDEEDEEGLLAWWRTVEGWSEW---- 165

Human   118 ELPRNEADELR-----KALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRAL 177
                ||:::.:     :|::..|.::.|..|           .|:..|.:.::.|:..|:.||||
Zfish   166 ----NESEQFKEEDGERAIEAAANRVFMAAK-----------LFVHLFLQREASLQQRIQDLRAL 215

Human   178 ADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMEL----GITAALTG 238
            ||.....||.|..|:|..|..|::..|.|:.|:.|||||.|.||::...|:.:    |:|:|...
Zfish   216 ADAADTFHKRTVTASVGGGVASVAGSITTITGLVLAPFTFGTSLIVTAVGIGVATAGGVTSASAN 280

Human   239 ITSST-------------MDYGKKWWTQAQAHDLVIKSLDKLKEVREFLG---ENISNFLSLAGN 287
            ||.:.             .||      |.:.||        :||..:||.   |.:..:     |
Zfish   281 ITDTVHSNTDRKKVEKMIQDY------QGEIHD--------IKECLDFLQAGMETLEQW-----N 326

Human   288 TYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEP--ISAESGEQVERVNEPSILEMSRG-V 349
            ..|....|.        ::|..|:|.|......|..:.  ::.||     .:|...:|.::.| .
Zfish   327 FEQYVNSIS--------SKALNQNVKHVLKEGGRAGKALLVNTES-----LINTVQVLSVAGGAA 378

Human   350 KLTDVAPVS------FFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILN------ 402
            |...|..|:      .||.||:.:|...|..|..|||:|.|:.:::|..||||.|..|.      
Zfish   379 KAAQVISVTSGIMSGLFLALDLFFLARGSMELRSGAKTEFAKRIREVCGELEEGLKELRRIQSQL 443

Human   403 ----NNYKILQADQE 413
                :..:|.:.|.|
Zfish   444 EKTMSGVQIQEEDDE 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
APOL1NP_663318.1 ApoL 104..403 CDD:461657 87/342 (25%)
apold1bXP_001920639.5 None

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