DRSC/TRiP Functional Genomics Resources

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Protein Alignment HMS1 and Mitf

DIOPT Version :9

Sequence 1:NP_014675.1 Gene:HMS1 / 854197 SGDID:S000005558 Length:434 Species:Saccharomyces cerevisiae
Sequence 2:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster


Alignment Length:487 Identity:112/487 - (22%)
Similarity:170/487 - (34%) Gaps:169/487 - (34%)


- Green bases have known domain annotations that are detailed below.


Yeast    10 GSSDG--NSVMNDLGNKVAIKVFDCRSAQDGSEEQNVNVTTN---------QMYLMFQSNNYNVP 63
            ||..|  .|...|.|:..|     |.|.....|:.:..|..:         ::.:..||...:||
  Fly   214 GSGQGLMESEFIDSGSTSA-----CGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVP 273

Yeast    64 PPNYNTEDLGSQGPPTHAYYAPFQHPIHLQPPVPPVYKNNTYSATDQYSDSSF-PNTSG-HTPVI 126
            |.......:...  ||.      .|.|..|       ||.    ..||...|| |:..| ||..|
  Fly   274 PQVLQVSTVLEN--PTR------YHVIQKQ-------KNQ----VRQYLSESFKPSMWGSHTSEI 319

Yeast   127 --------DSNYYNDALA-----------------------------SIPTTTTGSTTMTTDNGN 154
                    ..|..|.:|.                             ::|.:..|.:.:..|:.|
  Fly   320 KLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDIN 384

Yeast   155 TIDSEEYIDNMEVFSSEENENIDNVKQTDLKSEKDSSLLSAASIVKKEQLSGFENFLPLSKTESP 219
            .|:......|..  .:.|.||.....|..| |:.:|||.|..|      .||..|.:.:|.|.|.
  Fly   385 PIEPTVLRPNSH--GAGEPENAHRTAQLGL-SKANSSLSSTRS------SSGIVNSIRISSTSSS 440

Yeast   220 L-VTADEIKSSLN------------LENIDNADSMSFKLKTSPIRKHFH------VKPKRIT--- 262
            | .|:..|..|::            .::|...||.:|.       |:|:      .:|:.:|   
  Fly   441 LQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFD-------KNFNSELSIKQEPQNLTDAE 498

Yeast   263 -----RVRTGRVSHNIIEKKYRSNINDKIEQLRRTVPTLRVAYKKCNDLPITSRDLADLDGLEPA 322
                 :.|..:.:||:||::.|.||||:|::|...:|....|:.:      ..||:         
  Fly   499 MNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYE------VVRDI--------- 548

Yeast   323 TKLNKASILTKSIEYICHLERKCL---------------QLSLANQHLSNDTRD----------- 361
             :.||.:||..|::||     |||               |:.|.|:.|.:..::           
  Fly   549 -RPNKGTILKSSVDYI-----KCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGIL 607

Yeast   362 -SFVHLTE---PSQP-LSDNSSSEQVQKQTRS 388
             |..|||.   |:|| |...|.|....:..||
  Fly   608 LSENHLTSLSAPTQPYLKSFSLSPTASRSRRS 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HMS1NP_014675.1 bHLHzip_scHMS1_like 265..363 CDD:381405 30/124 (24%)
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:292573 15/57 (26%)
HLH 505..570 CDD:238036 26/85 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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