DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZIC5 and ref-2

DIOPT Version :10

Sequence 1:NP_149123.3 Gene:ZIC5 / 85416 HGNCID:20322 Length:639 Species:Homo sapiens
Sequence 2:NP_001024478.1 Gene:ref-2 / 183539 WormBaseID:WBGene00004335 Length:315 Species:Caenorhabditis elegans


Alignment Length:302 Identity:117/302 - (38%)
Similarity:144/302 - (47%) Gaps:72/302 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   325 PHLQHHAPPP------APPPPPAPAQHPHQHHPHLPGAAGAFLRYMRQPIKQELICKWIDPDELA 383
            |:...||..|      :..|...|||.....:|:..|:.|.         .:::.|.|    |..
 Worm    39 PYSDPHAYSPSFYMNMSQVPHFLPAQVDPFIYPNTLGSYGG---------DKQVQCLW----ETN 90

Human   384 GLPPPPPPPPPPPPPPPAGGAKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPF 448
            |                    :.|........||..|::..|:  ...|..||.|:.|.||.|.|
 Worm    91 G--------------------QVCMHVCQNSGELSTHISSNHI--THDSKFVCLWKGCDREFKMF 133

Human   449 KAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSD 513
            ||||||:||:||||||:||.|..  |.||||||||||||||.|:|||||:|..:||.:.||||||
 Worm   134 KAKYKLVNHMRVHTGERPFLCDV--CNKVFARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSD 196

Human   514 RKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGP-------LGYSSVGTPV 571
            ||||.|||:|.|||.|....|.|:||||||||||.|:|.........|       .|.:|:||  
 Worm   197 RKKHMHVHSSHKPYSCMYPDCGKTYTHPSSLRKHTKVHENEKKSQLSPEHDESSDSGNASIGT-- 259

Human   572 GAPLSPVLDPARSHSSTLSPQVTNLNEWYVCQASGAPSHLHT 613
                     |....|.|.||:  |:..         ..||||
 Worm   260 ---------PTTDESLTFSPE--NIKR---------DQHLHT 281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZIC5NP_149123.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..171
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..251
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..355 9/35 (26%)
zf_ZIC 366..429 CDD:436441 9/62 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 379..409 3/29 (10%)
COG5048 <405..551 CDD:227381 86/145 (59%)
C2H2 Zn finger 441..461 CDD:275368 14/19 (74%)
C2H2 Zn finger 469..491 CDD:275368 16/21 (76%)
C2H2 Zn finger 499..521 CDD:275368 14/21 (67%)
C2H2 Zn finger 529..551 CDD:275368 14/21 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..568 5/26 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..639 4/7 (57%)
ref-2NP_001024478.1 COG5048 150..>227 CDD:227381 52/78 (67%)
C2H2 Zn finger 154..174 CDD:275368 16/21 (76%)
C2H2 Zn finger 182..204 CDD:275368 14/21 (67%)
C2H2 Zn finger 212..234 CDD:275368 14/21 (67%)
Blue background indicates that the domain is not in the aligned region.

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