DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG6356

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	159/582 - (27%)
Similarity:	264/582 - (45%)	Gaps:	95/582 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    13 VGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNW----SLED 73
            ||..|.|...::|:|...||..|.|..:...:|..|                 ...|    .|:|
  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLP-----------------DDQWCGIPELQD 78

Human    74 TGALLSSGQKDYVTVQLQNG--EIWELSRCSRNKRENTSSLGYE----YTG------SKKEFPC- 125
            |. ...:.:::.|...|.:|  .:|:.:      ..:.:.:.||    |||      ...|..|
  Fly    79 TN-WTHAQKREIVAKGLDSGGCTVWDWN------YGHLAKMSYEAALNYTGHLTQISPPAEVSCR 136

Human   126 VDGYIYDQNTW---KSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWA 187
            |.|    |:.:   ::|.|..|:|.|||.......|.....|...||.:||..:|:.||:
  Fly   137 VKG----QHEFAHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRK----- 192

Human   188 TSSSMFLFGIA--------AAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASV 244
               |.|..|.|        ..|:..|..|:|.||.|...:||.....|..::|.|.:|.|:|.|:
  Fly   193 ---SSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSI 254

Human   245 HLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIV- 308
            ...:.:.||.:::|:.||:::.|...|:.|:..::..||.|:::.|:|.||::..||:...||:
  Fly   255 AFSASYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILF 319

Human   309 ---------DIMAKWNRASSCKLS----ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL 360
                     ..:|..::.:|.|.|    |..|...:  :.|.|.:    ::..|:.|..:.:...
  Fly   320 RQPSHYQIQPAVAAPSQVASDKKSLEPEEGFSFGQK--LKNGPLK----SIIELYANSKVRRMIF 378

Human   361 TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCS 425
            ..:.::...||.:|..:||:.||..:.||.:...|:|:||:|....|.:...|||....:....:
  Fly   379 ASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWT 443

Human   426 ALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASI 490
            .::..:|:.:|.......|..||:|:|.|.|.:.::.|||||||||.:|:.|:|:.|....:.||
  Fly   444 GVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSI 508

Human   491 LAPFSVD-LSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSS 551
            .||:.|| |.::..:||....|...|::|:|||.||||          ...||..:.||.:|
  Fly   509 SAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPET----------GTGKLSDKVESSAS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	153/563 (27%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577		3/9 (33%)
CG6356	NP_651240.1	MFS	167..544	CDD:119392	113/390 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6832
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800