Protein Alignment SLC22A16 and Orct

DIOPT Version :9

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 183/598 - (30%)
• Similarity: 294/598 - (49%)
• Gaps: 81/598 - (13%)

Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWS 70
            ::.:..|:|.||.:|:.:|::.....|.|..|.||.||:...|...|..|
  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP--------------- 52

Human    71 LEDTGALLSSGQKDYVTVQLQNGEIWELS----RCSRNKRENTSSLGYEYT---------GSKKE 122
                               .:||.|:|||    ..|..:.|..|....:||         .|..|
  Fly    53 -------------------YENGSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNE 98

Human   123 FPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWA 187
            ......|:||::.:.::|||:|||||.|..|:.....|||.||||||:.||..||:|||:...:|
  Fly    99 TKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFA 163

Human   188 TSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAV 252
            :.....:||:.||.|.:|:::..:|..:....||..:|.:|..:|.:|...|.:|.|.:..||:|
  Fly   164 SLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSV 228

Human   253 GTLLVALTGYLVRTW-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNR 316
            |.:|.|...|.:..| || |:.::...:.|:...|::||:..|||.:||.:||..|::..||.|:
  Fly   229 GFMLTAGFAYFIHDWRWL-QIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292

Human   317 ---------------ASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIW 366
                           |...|..|:        .::.|.......|.|.    ::.::||.::..|
  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEM--------AASQPAATVFDLLRYP----NLRRKTLLIFFDW 345

Human   367 FTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGV 431
            |..|..:|..|.|:.|||||:.:|..:.|.||||.||.:...:::.|||::|..::..:.::...
  Fly   346 FVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLA 410

Human   432 VMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSV 496
            .:.:|.....|.|..||:||.||.:::|.||:::||.:||:||::.:|:.|||.|:..||||:..
  Fly   411 TIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLK 475

Human   497 DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSG 561
            .|..||..:|.:..|.::|.:|:|:|.|||||.|.:..|.|     :.||..|......|....|
  Fly   476 LLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIE-----DGENFGKKPAPQETAEEGG 535

Human   562 LEKTEAITPRDSG 574
            .::...:....||
  Fly   536 TQELSGMLNGKSG 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	173/549 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		7/32 (22%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	173/549 (32%)
		MFS	135..491	CDD:119392	121/368 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		otm41229
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880