Protein Alignment SLC22A16 and Orct2

DIOPT Version :9

• Sequence 1: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 205/601 - (34%)
• Similarity: 313/601 - (52%)
• Gaps: 84/601 - (13%)

Human    10 YD----HVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWS 70
            ||    |:|.|||:|:::||:....:|....|.||.||:...|...|..|       |.|.|::.
  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-------FENGSSYD 60

Human    71 LEDTGALLSSGQKDYVTVQLQNGEIWELS-----RCSRNKRENTSSLGYEYTG-----SKKEFPC 125
            |..                    .:|.||     |||....:.|.    ||..     |..|...
  Fly    61 LPT--------------------HLWNLSYPENERCSYYDVDYTE----EYLNGSIPRSSNETKT 101

Human   126 VDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSS 190
            ...|:||::.:.::|||:|||||.|.::|.....|||.||||||:.||..||:.||:.:|:|:..
  Fly   102 CSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLV 166

Human   191 SMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTL 255
            ...|||:.|..|.:|:|:..||..:....||..:|.:|..||.:|...|.:|.:.:..||:||.:
  Fly   167 IQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFM 231

Human   256 LVALTGYLVRTW-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRA-- 317
            |.|:..|.|..| || |:.|:...:.|:...|::||:..|||.:||.:.|...:...|::|:.
  Fly   232 LTAVFAYFVHDWRWL-QIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEI 295

Human   318 SSCKLSELL-----------------SLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLI 365
            |...|||||                 .|| :||    |..|..     ||...::.::||.::|.
  Fly   296 SDEALSELLDEGENSEEKAKQKLEDQELD-EGP----PPSVWD-----LFCYPNLRRKTLLIFLD 350

Human   366 WFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACG 430
            |...|..:|..|.|:.|||||..||..:.|.||||||.|:.:.:::.|||::|...|..:.|:..
  Fly   351 WLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLL 415

Human   431 VVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFS 495
            ..::|||:.:.|.|..||:||.||.|::|.:|:::||.:||:||::|:|:.|||.|::.::|||.
  Fly   416 ATVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFL 480

Human   496 VDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSK--LLLTTN 558
            ..|::||..:|.|..|::.|::|:|:|.||||..|.:..|     ..:.|...|.:|  :.|.|.
  Fly   481 NFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLET-----IADGERFGKKTKADVYLETG 540

Human   559 NSGLEKTEAITPRDSG 574
            .. |...||...:.||
  Fly   541 QE-LRAPEAQPLKGSG 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	191/550 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		10/34 (29%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	191/550 (35%)
		MFS	127..503	CDD:119392	140/386 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		otm41229
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880