DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG7084

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	147/568 - (25%)
Similarity:	245/568 - (43%)	Gaps:	79/568 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     6 FEGIYDHVGHFGRFQRVLYFI----CAFQNISCGIHYLASVFMGV-----TPHHVCRPPGNVSQV 61
            |:.:.:..|:.||:|.:..|:    .||..        |.::|.:     .|.|.|..||
  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSG--------AMIYMNIILALNIPDHWCTVPG----- 85

Human    62 VFHNHSNWSLEDTGALL------SSGQKDYVT---VQLQNGEIWELSRCSRNKRENTSSLGYEYT 117
              ..::|:|||:...:.      :.|:|.:..   .|:...||.:.|..:.|..:.|.:
  Fly    86 --RENTNFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKTTEA------ 142

Human   118 GSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFG---VLLGSVTFGYFSDRL 179
                   |.:|:.||:..::||..|..|.||.:.   :.:..:|:.|   .:.||...|...|..
  Fly   143 -------CQNGWSYDKTWYESTIPTDHNWVCAKD---LFVTNVFVVGRVTEVAGSFILGQMGDSY 197

Human   180 GRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVM-EFIGMKSRTWAS 243
            |||.|.:.:.....|..:.:......||     :||.|.....|.|..::.. :.|||:......
  Fly   198 GRRFVYYISVVFCSLGRLGSIMCTSSYT-----WFLIMSGIVGLTVNSLFQSPQIIGMEISREED 257

Human   244 VHLHSFF-----AVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEE 303
            ....:||     ::||.|:.|..:.:|.|..:..:.|..|...:|....:.|:|.||:|:.|:.|
  Fly   258 RSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFRE 322

Human   304 A----QKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWL 364
            |    |||..|.......:..:|:|:.|.|.|...         :.::.||..|.:.:.|..:..
  Fly   323 AIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVT---------YGIASLFAGWRLARNTTIMGF 378

Human   365 IWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALAC 429
            .|...::.:::..|.|..:.||.:||.....:||||||.......|..|||...:.|...|.:.|
  Fly   379 SWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTC 443

Human   430 GVVMV--IPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILA 492
            ..::|  ..:::..|.:..|...||.....|..:.|...|:|||.:|...|..|:::.....:||
  Fly   444 LPIIVYSTDERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLA 508

Human   493 PFSVDL-SSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEA 539
            |:.|.| :::.|..|...:|.:.||.|:..|.|||||.|:|..|.|||
  Fly   509 PYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEA 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	142/554 (26%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	135/524 (26%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	97/371 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920