DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG6231

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	130/557 - (23%)
Similarity:	234/557 - (42%)	Gaps:	71/557 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWS 70
            |:.|....|.|.|:|.::..:..|.||...:||.....:...|.|.|          :|:
  Fly     3 FDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWC----------YHD----- 52

Human    71 LEDTGALLSSGQKDYVTVQLQNGEIW---ELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYD 132
                 .|::...|:.       |||:   |...|:|....|    |:..|.|.|   ..:.:||:
  Fly    53 -----KLVNMTYKEI-------GEIYAQFENPSCTRLDDIN----GHNVTVSSK---ACEKWIYN 98

Human   133 QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGI 197
            .:....:..|:.|.|||..:.|.:.|.||..|.::|::.:|..||::||...|..::...|....
  Fly    99 YDFGYRSMNTELNWVCDSAYKARIGQSLFFIGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDF 163

Human   198 AAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWA-SVHLHSFFAVGTLLVALTG 261
            :..|.....||...||...:.|.....:.::.|:|:|....||.. ::.:..|:.:|.:......
  Fly   164 STIFTKSVATFTLCRFISGLAADTNFYLMYIIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLA 228

Human   262 YLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLS--- 323
            .||..|.:|....|...:..:|..:|:.|:..||::....:.|...:..:||:|   .|::|
  Fly   229 VLVGHWQIYLACTSLPILLVVLYYFVVQESAQWLVTRNDIDGAIVRLKRVAKFN---GCRVSQAD 290

Human   324 ------------ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSF 376
                        |:|..|          :.::..|..:|....:.|.||.::......:|.:.:.
  Fly   291 FDEFRRHCQMTHEMLGGD----------DKKQATLLDMFRTPRMRKNTLILFFKSMVITLCYDAV 345

Human   377 SLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSAL---ACGVVMVIPQK 438
            |.|...:|.:.::...|..:..:|:...:.:..|::||:.:.:.||....|   |.|:.:...|.
  Fly   346 SRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKGMASGSLLVGGLFTAAAGIAIAYQQH 410

Human   439 HY--ILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSI 501
            ::  ||.....:..:|.:..::.....|..||.||.||...|.:..:....||.|||:.:.|.:.
  Fly   411 NHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQGVAAVHVAGFAASFLAPYILWLGTF 475

Human   502 WIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538
            :...|.:.:|.:......:.|.|||||.:.|.||.||
  Fly   476 FKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	124/544 (23%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	124/544 (23%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	83/386 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153544
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850