DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC22A16 and CG42269

DIOPT Version :9

Sequence 1:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	149/555 - (26%)
Similarity:	256/555 - (46%)	Gaps:	61/555 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     3 SRHFEGIYDHVGHFGRFQRVLYFICAFQ-NISCGIHYLASVFMGVTP-HHVCRPPGNVSQVVFHN 65
            |..|:.|...:|.|||:|::| |||... :......|.:.:|:.:.| .|.|..|
  Fly    69 SMDFDDILPLIGEFGRYQKLL-FICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP---------- 122

Human    66 HSNWSLE--DTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFP---C 125
                .|:  |..|.|:      :::.:.||   |.:.|.......|..|......:..::|   |
  Fly   123 ----ELDGLDVEARLA------LSIPMTNG---EYNNCYMYDVNYTDILAQGKVMADPKWPQVKC 174

Human   126 VDGYIYD-QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATS 189
            ..|:.|: .....:|..|:.|.|||...|....|.:|..|.::|.:.||:.:||.||...|..|:
  Fly   175 RHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTN 239

Human   190 SSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTW-ASVHLHSFFAVG 253
            ....|.|:..||..:::.|...|||:.........:.::.|:|::|.|.||: |::.:..||...
  Fly   240 MMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGA 304

Human   254 TLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNR-- 316
            ..|:....|.:..|.|..::.|...:..|...:|:||:..||:|:|:.::|..|:..:.|.|.
  Fly   305 ACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQ 369

Human   317 ---------ASSCKLSELLSLDLQGPVSNSPTEVQ--KHNLSYLFYNWSITKRTLTVWLIWFTGS 370
                     ..|||..:             ..|.|  |:::..||.:..:.:.||.:.:||...|
  Fly   370 VPPQTYQIFTDSCKRMQ-------------EQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAIS 421

Human   371 LGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVI 435
            |.|.....|..:||.:.:....|....|:||.|.:.:.:|:.|||.:...|:..|.:...:..|:
  Fly   422 LVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVV 486

Human   436 PQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSS 500
            |...|  ....|::|:|.:..::.:...:.||:.||:||:.||....::..:|||:|||.|.|::
  Fly   487 PVGIY--SAALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLAN 549

Human   501 IWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATT 535
            |...:|.:.:|.:.::.|:|.|.|||||...|..|
  Fly   550 ISQALPLIILGILGIIGGLLALLLPETLNHVLPQT 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	145/542 (27%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	134/510 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	95/353 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850